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    SUN2 Sad1 and UNC84 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 25777, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SUN2provided by HGNC
    Official Full Name
    Sad1 and UNC84 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:14210
    See related
    Ensembl:ENSG00000100242 MIM:613569; AllianceGenome:HGNC:14210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNC84B; rab5IP
    Summary
    SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in fat (RPKM 47.2), bone marrow (RPKM 33.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    22q13.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38734734..38755998, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39204948..39226213, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39130739..39152003, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13726 Neighboring gene Josephin domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39100707-39101392 Neighboring gene hESC enhancers GRCh37_chr22:39101393-39102078 and GRCh37_chr22:39102079-39102764 Neighboring gene GTP binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19017 Neighboring gene peroxiredoxin 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39156221-39157045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39175672-39176172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13732 Neighboring gene dynein axonemal light chain 4 Neighboring gene neuronal pentraxin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUN2 Modulates the Propagation of HSV-1. Cruz-Palomar K, et al. J Virol, 2022 May 11. PMID 35435724, Free PMC Article
    2. Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1. Liu L, et al. J Pathol, 2021 Aug. PMID 33931868
    3. Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention. Koedoot E, et al. J Exp Clin Cancer Res, 2021 Mar 1. PMID 33648524, Free PMC Article
    4. SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer. Lv XB, et al. Sci Rep, 2015 Dec 10. PMID 26658802, Free PMC Article
    5. Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. Zhou Z, et al. J Biol Chem, 2012 Feb 17. PMID 22170055, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUN2 Modulates the Propagation of HSV-1.
      Title: SUN2 Modulates the Propagation of HSV-1.
    2. FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.
      Title: FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.
    3. Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
      Title: Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1.
    4. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
      Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
    5. Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention.
      Title: Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention.
    6. Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
      Title: Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
    7. SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
      Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
    8. a fragment of SUN2 containing CC1, CC2, and the SUN domain model is reported.
      Title: A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
    9. SUN2 is a novel chromatin reassembly factor that helps to maintain chromatin in a repressive state and consequently inhibits HIV-1 transcription.
      Title: SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin.
    10. While Sun1 and Sun2 in HeLa cells are each able to bind KASH-domains, Sun1 is more efficiently incorporated into LINC complexes under normal growth conditions. Furthermore, the balance of Sun1 and Sun2 incorporated into LINC complexes is cell type-specific and is correlated with SRF/Mkl1-dependent gene expression.
      Title: Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 replication, specifically nuclear import, is inhibited by SUN2 overexpression as it changes nuclear shape in cell lines and primary cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0668, MGC133055, MGC133056

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear matrix anchoring at nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear migration along microfilament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    SUN domain-containing protein 2
    Names
    Sad1 unc-84 domain protein 2
    nuclear envelope protein
    protein unc-84 homolog B
    rab5-interacting protein
    sad1/unc-84 protein-like 2
    unc-84 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199579.2 → NP_001186508.1  SUN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK304188, AL021707, BC094797, BX537962, CB988569, CD365855
      Consensus CDS
      CCDS56231.1
      UniProtKB/TrEMBL
      A8K129
      Related
      ENSP00000385616.1, ENST00000405018.5
      Conserved Domains (4) summary
      COG1196
      Location:292 → 568
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:602 → 736
      Sad1_UNC; Sad1 / UNC-like C-terminal
      cd21438
      Location:421 → 475
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins
      pfam18580
      Location:502 → 559
      Sun2_CC2; SUN2 coiled coil domain 2

    2. NM_001199580.2 → NP_001186509.1  SUN domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001186509.1

      Status: VALIDATED

      Source sequence(s)
      AK304188, AL021707, BX537962, CD365855, DC400744
      Consensus CDS
      CCDS13978.1
      UniProtKB/Swiss-Prot
      B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
      UniProtKB/TrEMBL
      A8K129
      Related
      ENSP00000385740.1, ENST00000405510.5
      Conserved Domains (4) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:581 → 715
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:481 → 538
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:400 → 454
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    3. NM_001394427.1 → NP_001381356.1  SUN domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (1) summary
      COG1196
      Location:302 → 578
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_001394428.1 → NP_001381357.1  SUN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS56231.1
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (4) summary
      COG1196
      Location:292 → 568
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:602 → 736
      Sad1_UNC; Sad1 / UNC-like C-terminal
      cd21438
      Location:421 → 475
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins
      pfam18580
      Location:502 → 559
      Sun2_CC2; SUN2 coiled coil domain 2

    5. NM_001394429.1 → NP_001381358.1  SUN domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (1) summary
      COG1196
      Location:286 → 562
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. NM_001394430.1 → NP_001381359.1  SUN domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (1) summary
      COG1196
      Location:286 → 562
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. NM_001394431.1 → NP_001381360.1  SUN domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS93166.1
      UniProtKB/TrEMBL
      A8K129, B0QY60
      Conserved Domains (1) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. NM_001394432.1 → NP_001381361.1  SUN domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS13978.1
      UniProtKB/Swiss-Prot
      B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
      UniProtKB/TrEMBL
      A8K129
      Related
      ENSP00000508791.1, ENST00000690927.1
      Conserved Domains (4) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:581 → 715
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:481 → 538
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:400 → 454
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    9. NM_001394433.1 → NP_001381362.1  SUN domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS13978.1
      UniProtKB/Swiss-Prot
      B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (4) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:581 → 715
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:481 → 538
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:400 → 454
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    10. NM_001394434.1 → NP_001381363.1  SUN domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS13978.1
      UniProtKB/Swiss-Prot
      B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (4) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:581 → 715
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:481 → 538
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:400 → 454
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    11. NM_001394435.1 → NP_001381364.1  SUN domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS13978.1
      UniProtKB/Swiss-Prot
      B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (4) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:581 → 715
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:481 → 538
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:400 → 454
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    12. NM_001394436.1 → NP_001381365.1  SUN domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (1) summary
      COG1196
      Location:271 → 521
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. NM_001394437.1 → NP_001381366.1  SUN domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (1) summary
      COG1196
      Location:271 → 521
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. NM_001394438.1 → NP_001381367.1  SUN domain-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A8K129
      Conserved Domains (1) summary
      COG1196
      Location:241 → 517
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    15. NM_001394439.1 → NP_001381368.1  SUN domain-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS93165.1
      UniProtKB/TrEMBL
      B0QY64, B4DIU6
      Conserved Domains (4) summary
      COG1196
      Location:225 → 501
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:535 → 669
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:435 → 492
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:354 → 408
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    16. NM_001394440.1 → NP_001381369.1  SUN domain-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS93165.1
      UniProtKB/TrEMBL
      B0QY64, B4DIU6
      Related
      ENSP00000415588.3, ENST00000456894.6
      Conserved Domains (4) summary
      COG1196
      Location:225 → 501
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:535 → 669
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:435 → 492
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:354 → 408
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    17. NM_001394441.1 → NP_001381370.1  SUN domain-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Consensus CDS
      CCDS93165.1
      UniProtKB/TrEMBL
      B0QY64, B4DIU6
      Conserved Domains (4) summary
      COG1196
      Location:225 → 501
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:535 → 669
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:435 → 492
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:354 → 408
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    18. NM_001394442.1 → NP_001381371.1  SUN domain-containing protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A0A8I5QKM0
      Conserved Domains (1) summary
      TIGR00618
      Location:269 → 417
      sbcc; exonuclease SbcC

    19. NM_001394443.1 → NP_001381372.1  SUN domain-containing protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL021707
      Conserved Domains (1) summary
      COG1196
      Location:107 → 383
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    20. NM_001394444.1 → NP_001381373.1  SUN domain-containing protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A0A8I5QKM0

    21. NM_001394445.1 → NP_001381374.1  SUN domain-containing protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL021707
      UniProtKB/TrEMBL
      A0A8I5QKM0

    22. NM_015374.3 → NP_056189.1  SUN domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_056189.1

      Status: VALIDATED

      Source sequence(s)
      AK304188, BC094797, BX537962, CB988569, CD365855, CN299688
      Consensus CDS
      CCDS13978.1
      UniProtKB/Swiss-Prot
      B0QY62, O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3, Q9UH99
      UniProtKB/TrEMBL
      A8K129
      Related
      ENSP00000508608.1, ENST00000689035.1
      Conserved Domains (4) summary
      COG1196
      Location:271 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:581 → 715
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam18580
      Location:481 → 538
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21438
      Location:400 → 454
      SUN2_cc1; coiled-coil domain 1 of SUN domain-containing protein 2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38734734..38755998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028748.2 → XP_016884237.1  SUN domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K129

    2. XM_047441310.1 → XP_047297266.1  SUN domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B0QY60

    3. XM_047441313.1 → XP_047297269.1  SUN domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B0QY60

    4. XM_047441312.1 → XP_047297268.1  SUN domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B0QY60
      Related
      ENSP00000390154.2, ENST00000455125.2

    5. XM_047441311.1 → XP_047297267.1  SUN domain-containing protein 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      39204948..39226213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325481.1 → XP_054181456.1  SUN domain-containing protein 2 isoform X2

    2. XM_054325480.1 → XP_054181455.1  SUN domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B0QY60

    3. XM_054325484.1 → XP_054181459.1  SUN domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B0QY60

    4. XM_054325483.1 → XP_054181458.1  SUN domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B0QY60

    5. XM_054325482.1 → XP_054181457.1  SUN domain-containing protein 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UH99.3 GenPept UniProtKB/Swiss-Prot:Q9UH99

    Gene LinkOut

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