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    MAPK7 mitogen-activated protein kinase 7 [ Homo sapiens (human) ]

    Gene ID: 5598, updated on 2-May-2024

    Summary

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    Official Symbol
    MAPK7provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 7provided by HGNC
    Primary source
    HGNC:HGNC:6880
    See related
    Ensembl:ENSG00000166484 MIM:602521; AllianceGenome:HGNC:6880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMK1; ERK4; ERK5; PRKM7
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19377750..19383544)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19325785..19331579)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19281063..19286857)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 2588 Neighboring gene microRNA 1180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19261015-19261514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8288 Neighboring gene uncharacterized LOC105371573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19266095-19266879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19275949-19276498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19283774-19284736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19285982-19286482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19286483-19286983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19288791-19289336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289337-19289882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289883-19290428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19294419-19295332 Neighboring gene microfibril associated protein 4 Neighboring gene uncharacterized LOC124903947 Neighboring gene ring finger protein 112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications. Sánchez-Fdez A, et al. Exp Mol Med, 2023 Jun. PMID 37332046, Free PMC Article
    2. The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk. Cacina C, et al. In Vivo, 2023 Mar-Apr. PMID 36881097, Free PMC Article
    3. Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity. Ippolito F, et al. Cell Death Dis, 2023 Jan 17. PMID 36650140, Free PMC Article
    4. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Kotla S, et al. Redox Biol, 2021 Nov. PMID 34619528, Free PMC Article
    5. Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells. Gentilini A, et al. Hepatology, 2021 Oct. PMID 33959996, Free PMC Article

    See all (231) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
      Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    2. An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.
      Title: An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.
    3. ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells.
      Title: ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells.
    4. MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.
      Title: MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.
    5. Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition.
      Title: Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition.
    6. Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications.
      Title: Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications.
    7. VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
      Title: VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
    8. The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk.
      Title: The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk.
    9. Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity.
      Title: Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity.
    10. Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5.
      Title: Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5.
    Submit: New GeneRIF Correction See all GeneRIFs (169)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme inhibitor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to laminar fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to laminar fluid shear stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of response to cytokine stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 7
    Names
    BMK-1
    BMK1 kinase
    ERK-5
    MAP kinase 7
    MAPK 7
    big MAP kinase 1
    extracellular-signal-regulated kinase 5
    NP_002740.2
    NP_620601.1
    NP_620602.2
    NP_620603.2
    XP_006721620.1
    XP_006721621.1
    XP_006721622.1
    XP_011522259.1
    XP_047292357.1
    XP_047292358.1
    XP_047292359.1
    XP_047292360.1
    XP_047292361.1
    XP_047292362.1
    XP_047292363.1
    XP_054172645.1
    XP_054172646.1
    XP_054172647.1
    XP_054172648.1
    XP_054172649.1
    XP_054172650.1
    XP_054172651.1
    XP_054172652.1
    XP_054172653.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002749.4 → NP_002740.2  mitogen-activated protein kinase 7 isoform 1

      See identical proteins and their annotated locations for NP_002740.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is also known as BMK1 gamma. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
      Source sequence(s)
      BC009963, BC030134, DA452383
      Consensus CDS
      CCDS11206.1
      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENSP00000378968.3, ENST00000395604.8
      Conserved Domains (2) summary
      smart00220
      Location:55 → 347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49 → 384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    2. NM_139032.3 → NP_620601.1  mitogen-activated protein kinase 7 isoform 2

      See identical proteins and their annotated locations for NP_620601.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' region, which includes the translation start codon, when compared to variant 1. The translation of this transcript begins at a downstream in-frame start codon, and thus results in an N-terminal truncated isoform (2), as compared to isoform 1.
      Source sequence(s)
      BC007404, BC030134, DB133227
      Consensus CDS
      CCDS11207.1
      UniProtKB/Swiss-Prot
      Q13164
      Related
      ENSP00000299612.7, ENST00000299612.11
      Conserved Domains (2) summary
      smart00220
      Location:4 → 208
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 245
      PKc_like; Protein Kinases, catalytic domain

    3. NM_139033.3 → NP_620602.2  mitogen-activated protein kinase 7 isoform 1

      See identical proteins and their annotated locations for NP_620602.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is also known as BMK1 alpha. It encodes a longer isoform (1), as compared to variant 2. Variants 1, 3 and 4 encode the same isoform.
      Source sequence(s)
      BC030134, DB133227, U29725
      Consensus CDS
      CCDS11206.1
      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENSP00000311005.5, ENST00000308406.9
      Conserved Domains (2) summary
      smart00220
      Location:55 → 347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49 → 384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    4. NM_139034.3 → NP_620603.2  mitogen-activated protein kinase 7 isoform 1

      See identical proteins and their annotated locations for NP_620603.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is also known as BMK1 beta. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
      Source sequence(s)
      BC030134, U29726
      Consensus CDS
      CCDS11206.1
      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENSP00000378966.4, ENST00000395602.8
      Conserved Domains (2) summary
      smart00220
      Location:55 → 347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49 → 384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      19377750..19383544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721558.4 → XP_006721621.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006721621.1

      UniProtKB/TrEMBL
      B4DI23
      Conserved Domains (2) summary
      smart00220
      Location:55 → 353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49 → 390
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    2. XM_047436404.1 → XP_047292360.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      Related
      ENST00000490660.2

    3. XM_047436402.1 → XP_047292358.1  mitogen-activated protein kinase 7 isoform X1

    4. XM_047436406.1 → XP_047292362.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

    5. XM_006721557.4 → XP_006721620.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006721620.1

      UniProtKB/TrEMBL
      B4DI23
      Conserved Domains (2) summary
      smart00220
      Location:55 → 353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49 → 390
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    6. XM_047436403.1 → XP_047292359.1  mitogen-activated protein kinase 7 isoform X1

    7. XM_047436405.1 → XP_047292361.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

    8. XM_006721559.4 → XP_006721622.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006721622.1

      UniProtKB/TrEMBL
      B4DI23
      Conserved Domains (2) summary
      smart00220
      Location:55 → 353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49 → 390
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    9. XM_011523957.4 → XP_011522259.1  mitogen-activated protein kinase 7 isoform X4

      See identical proteins and their annotated locations for XP_011522259.1

      UniProtKB/Swiss-Prot
      Q13164
      Conserved Domains (2) summary
      smart00220
      Location:4 → 208
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 245
      PKc_like; Protein Kinases, catalytic domain

    10. XM_047436407.1 → XP_047292363.1  mitogen-activated protein kinase 7 isoform X3

    11. XM_047436401.1 → XP_047292357.1  mitogen-activated protein kinase 7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      19325785..19331579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316672.1 → XP_054172647.1  mitogen-activated protein kinase 7 isoform X1

    2. XM_054316673.1 → XP_054172648.1  mitogen-activated protein kinase 7 isoform X1

    3. XM_054316676.1 → XP_054172651.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

    4. XM_054316670.1 → XP_054172645.1  mitogen-activated protein kinase 7 isoform X1

    5. XM_054316674.1 → XP_054172649.1  mitogen-activated protein kinase 7 isoform X1

    6. XM_054316675.1 → XP_054172650.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51

    7. XM_054316671.1 → XP_054172646.1  mitogen-activated protein kinase 7 isoform X1

    8. XM_054316678.1 → XP_054172653.1  mitogen-activated protein kinase 7 isoform X4

    9. XM_054316677.1 → XP_054172652.1  mitogen-activated protein kinase 7 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13164.2 GenPept UniProtKB/Swiss-Prot:Q13164

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