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    SNRPG small nuclear ribonucleoprotein polypeptide G [ Homo sapiens (human) ]

    Gene ID: 6637, updated on 5-May-2024

    Summary

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    Official Symbol
    SNRPGprovided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Gprovided by HGNC
    Primary source
    HGNC:HGNC:11163
    See related
    Ensembl:ENSG00000143977 MIM:603542; AllianceGenome:HGNC:11163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMG; Sm-G
    Summary
    The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in colon (RPKM 14.7), appendix (RPKM 13.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70281362..70293740, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70293098..70305490, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70508494..70520872, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11610 Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene prenylcysteine oxidase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70519630-70520537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16007 Neighboring gene uncharacterized LOC124906023 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70527535-70528484 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70528485-70529433 Neighboring gene family with sequence similarity 136 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11612 Neighboring gene Sharpr-MPRA regulatory region 10868 Neighboring gene bromodomain containing 7 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway. Lan Y, et al. Cancer Biol Med, 2020 Feb 15. PMID 32296580, Free PMC Article
    2. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. Heinrichs V, et al. J Mol Biol, 1992 Sep 5. PMID 1387914
    3. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Conte N, et al. Oncogene, 2002 Aug 15. PMID 12165861
    4. Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core. Plessel G, et al. J Mol Biol, 1997 Jan 17. PMID 9020971
    5. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. Hermann H, et al. EMBO J, 1995 May 1. PMID 7744013, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway.
      Title: Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide G (SNRPG), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRPG is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117317

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 7-methylguanosine cap hypermethylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in U2-type prespliceosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN-Sm protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of U1 snRNP NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4 snRNP NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of U7 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of methylosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small nuclear ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of spliceosomal complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small nuclear ribonucleoprotein G
    Names
    sm protein G
    snRNP-G
    NP_001304094.1
    NP_001304095.1
    NP_001304096.1
    NP_001304097.1
    NP_001304098.1
    NP_001304100.1
    NP_003087.1
    XP_016860263.1
    XP_054199495.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317165.2 → NP_001304094.1  small nuclear ribonucleoprotein G isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI742299, BP424287, DW428820
      Consensus CDS
      CCDS82463.1
      UniProtKB/TrEMBL
      C9JVQ0
      Related
      ENSP00000393388.1, ENST00000454893.1
      Conserved Domains (1) summary
      cd01719
      Location:5 → 60
      Sm_G; Sm protein G

    2. NM_001317166.2 → NP_001304095.1  small nuclear ribonucleoprotein G isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AI742299, AV682126, BU540400
      UniProtKB/Swiss-Prot
      A8MWD9
      Conserved Domains (1) summary
      cd01719
      Location:5 → 73
      Sm_G; Sm protein G

    3. NM_001317167.1 → NP_001304096.1  small nuclear ribonucleoprotein G isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI290354, AI742299
      Consensus CDS
      CCDS82462.1
      UniProtKB/Swiss-Prot
      A8MWD9
      UniProtKB/TrEMBL
      F5H013
      Related
      ENSP00000416334.2, ENST00000413456.6
      Conserved Domains (1) summary
      cd01719
      Location:4 → 66
      Sm_G; Sm protein G

    4. NM_001317168.1 → NP_001304097.1  small nuclear ribonucleoprotein G isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AI742299, BC035103, HY168189
      Consensus CDS
      CCDS82461.1
      UniProtKB/Swiss-Prot
      A8MWD9
      UniProtKB/TrEMBL
      C9J303, Q49AN9
      Related
      ENSP00000441332.1, ENST00000482975.6
      Conserved Domains (1) summary
      cd01719
      Location:1 → 62
      Sm_G; Sm protein G

    5. NM_001317169.2 → NP_001304098.1  small nuclear ribonucleoprotein G isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains two alternate exons in place of the first exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (e).
      Source sequence(s)
      AC079338, AI742299, HY168189
      Consensus CDS
      CCDS82461.1
      UniProtKB/Swiss-Prot
      A8MWD9
      UniProtKB/TrEMBL
      C9J303, Q49AN9
      Related
      ENSP00000402194.1, ENST00000438261.5
      Conserved Domains (1) summary
      cd01719
      Location:1 → 62
      Sm_G; Sm protein G

    6. NM_001317171.2 → NP_001304100.1  small nuclear ribonucleoprotein G isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (f) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AI742299, AV682126, CD109295
      Related
      ENST00000429728.1
      Conserved Domains (1) summary
      cd01719
      Location:2 → 56
      Sm_G; Sm protein G

    7. NM_003096.4 → NP_003087.1  small nuclear ribonucleoprotein G isoform a

      See identical proteins and their annotated locations for NP_003087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the highly conserved isoform (a).
      Source sequence(s)
      AI742299, BC106055, DW428820
      Consensus CDS
      CCDS1903.1
      UniProtKB/Swiss-Prot
      A8MWD9, D6W5G6, P62308, Q15357, Q6IB86
      Related
      ENSP00000272348.2, ENST00000272348.7
      Conserved Domains (1) summary
      cd01719
      Location:5 → 74
      Sm_G; Sm protein G

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      70281362..70293740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004774.2 → XP_016860263.1  small nuclear ribonucleoprotein G isoform X1

      UniProtKB/TrEMBL
      C9JVQ0
      Conserved Domains (1) summary
      cd01719
      Location:5 → 60
      Sm_G; Sm protein G

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      70293098..70305490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343520.1 → XP_054199495.1  small nuclear ribonucleoprotein G isoform X1

      UniProtKB/TrEMBL
      C9JVQ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62308.1 GenPept UniProtKB/Swiss-Prot:P62308

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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