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    FOXJ3 forkhead box J3 [ Homo sapiens (human) ]

    Gene ID: 22887, updated on 5-May-2024

    Summary

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    Official Symbol
    FOXJ3provided by HGNC
    Official Full Name
    forkhead box J3provided by HGNC
    Primary source
    HGNC:HGNC:29178
    See related
    Ensembl:ENSG00000198815 MIM:616035; AllianceGenome:HGNC:29178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.6), testis (RPKM 10.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p34.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (42176548..42335880, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (42047196..42206280, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (42642219..42801551, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:42630276-42631240 Neighboring gene Sharpr-MPRA regulatory region 9331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:42638778-42639405 Neighboring gene guanylate cyclase activator 2B Neighboring gene guanylate cyclase activator 2A Neighboring gene Sharpr-MPRA regulatory region 10195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:42799881-42800838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 761 Neighboring gene ribosomal modification protein rimK like family member A Neighboring gene ribosomal protein S15a pseudogene 8 Neighboring gene zinc finger MYND-type containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis. Ban JY, et al. Mol Med Rep, 2013 Oct. PMID 23933633
    2. FOXJ3 Regulates Cell Proliferation and Motility Through Modulating Snail Expression in Breast Cancer Cells. Seo Y, et al. Anticancer Res, 2023 Jul. PMID 37351974
    3. MicroRNA-425-5p promotes the development of prostate cancer via targeting forkhead box J3. Zhang JY, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30720162
    4. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression. Jin J, et al. Life Sci, 2014 Jul 11. PMID 24846831
    5. Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis. Yong W, et al. Cell Cycle, 2021 Dec. PMID 34724864, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXJ3 Regulates Cell Proliferation and Motility Through Modulating Snail Expression in Breast Cancer Cells.
      Title: FOXJ3 Regulates Cell Proliferation and Motility Through Modulating Snail Expression in Breast Cancer Cells.
    2. Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.
      Title: Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.
    3. Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene.
      Title: Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene.
    4. The found the stimulation effects of miR-425-5p on prostate cancer (PCa) cell behaviors were fulfilled through directly regulating the expression of FOXJ3, which validated FOXJ3 as a functional target of miR-425-5p in PCa.
      Title: MicroRNA-425-5p promotes the development of prostate cancer via targeting forkhead box J3.
    5. FOXO3-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 and FOXO3 where both factors play a regulatory role.
      Title: Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors.
    6. This study demonstrated that miR-517a-3p promoted lung cancer cell proliferation and invasion by targeting of FOXJ3 expression
      Title: MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression.
    7. FOXJ3 may be associated with the development of rheumatoid arthritis.
      Title: Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis.
    8. FOXJ3 is identified as a novel cell cycle reguulator that may regulate a network of zinc finger proteins.
      Title: Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC165036, MGC176686

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein J3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198850.2 → NP_001185779.1  forkhead box protein J3 isoform 1

      See identical proteins and their annotated locations for NP_001185779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC096540, AK027075, BC063298, BC151828
      Consensus CDS
      CCDS30689.1
      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000361654.1, ENST00000372573.5
      Conserved Domains (2) summary
      pfam00250
      Location:78 → 155
      Forkhead; Forkhead domain
      pfam15258
      Location:339 → 445
      FAM222A; Protein family of FAM222A

    2. NM_001198851.2 → NP_001185780.1  forkhead box protein J3 isoform 1

      See identical proteins and their annotated locations for NP_001185780.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has two additional exons in the 5' UTR, as compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK027075, BC063298, BC151828, BC152441
      Consensus CDS
      CCDS30689.1
      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000361653.1, ENST00000372572.5
      Conserved Domains (2) summary
      pfam00250
      Location:78 → 155
      Forkhead; Forkhead domain
      pfam15258
      Location:339 → 445
      FAM222A; Protein family of FAM222A

    3. NM_001198852.2 → NP_001185781.1  forkhead box protein J3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB028964, AC096540, AK027075, BC014182, BC063298, BC151828
      Consensus CDS
      CCDS55594.1
      UniProtKB/Swiss-Prot
      Q9UPW0
      Related
      ENSP00000354449.1, ENST00000361776.5
      Conserved Domains (1) summary
      pfam00250
      Location:78 → 155
      Forkhead; Forkhead domain

    4. NM_014947.5 → NP_055762.3  forkhead box protein J3 isoform 1

      See identical proteins and their annotated locations for NP_055762.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC096540, AK027075, BC063298, BC151828
      Consensus CDS
      CCDS30689.1
      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000354620.1, ENST00000361346.6
      Conserved Domains (2) summary
      pfam00250
      Location:78 → 155
      Forkhead; Forkhead domain
      pfam15258
      Location:339 → 445
      FAM222A; Protein family of FAM222A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      42176548..42335880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449488.1 → XP_047305444.1  forkhead box protein J3 isoform X5

    2. XM_024454163.2 → XP_024309931.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Conserved Domains (2) summary
      pfam00250
      Location:78 → 155
      Forkhead; Forkhead domain
      pfam15258
      Location:339 → 445
      FAM222A; Protein family of FAM222A

    3. XM_047449489.1 → XP_047305445.1  forkhead box protein J3 isoform X5

    4. XM_047449474.1 → XP_047305430.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0

    5. XM_047449471.1 → XP_047305427.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0

    6. XM_047449478.1 → XP_047305434.1  forkhead box protein J3 isoform X2

      UniProtKB/Swiss-Prot
      A7MBL7, A7MD18, D3DPW2, Q9NSS7, Q9UPW0
      Related
      ENSP00000439044.1, ENST00000545068.5

    7. XM_017000693.3 → XP_016856182.1  forkhead box protein J3 isoform X6

    8. XM_006710458.5 → XP_006710521.1  forkhead box protein J3 isoform X3

      Conserved Domains (1) summary
      pfam00250
      Location:63 → 140
      Forkhead; Forkhead domain

    9. XM_006710459.4 → XP_006710522.1  forkhead box protein J3 isoform X4

      Conserved Domains (1) summary
      pfam00250
      Location:86 → 163
      Forkhead; Forkhead domain

    10. XM_005270632.5 → XP_005270689.1  forkhead box protein J3 isoform X1

      Conserved Domains (1) summary
      pfam00250
      Location:86 → 163
      Forkhead; Forkhead domain

    11. XM_047449486.1 → XP_047305442.1  forkhead box protein J3 isoform X3

    12. XM_017000694.2 → XP_016856183.1  forkhead box protein J3 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      42047196..42206280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335198.1 → XP_054191173.1  forkhead box protein J3 isoform X5

    2. XM_054335194.1 → XP_054191169.1  forkhead box protein J3 isoform X2

    3. XM_054335199.1 → XP_054191174.1  forkhead box protein J3 isoform X5

    4. XM_054335193.1 → XP_054191168.1  forkhead box protein J3 isoform X2

    5. XM_054335192.1 → XP_054191167.1  forkhead box protein J3 isoform X2

    6. XM_054335195.1 → XP_054191170.1  forkhead box protein J3 isoform X2

    7. XM_054335200.1 → XP_054191175.1  forkhead box protein J3 isoform X6

    8. XM_054335196.1 → XP_054191171.1  forkhead box protein J3 isoform X3

    9. XM_054335197.1 → XP_054191172.1  forkhead box protein J3 isoform X3

    10. XM_054335201.1 → XP_054191176.1  forkhead box protein J3 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPW0.2 GenPept UniProtKB/Swiss-Prot:Q9UPW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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