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    KDM2B lysine demethylase 2B [ Homo sapiens (human) ]

    Gene ID: 84678, updated on 5-May-2024

    Summary

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    Official Symbol
    KDM2Bprovided by HGNC
    Official Full Name
    lysine demethylase 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:13610
    See related
    Ensembl:ENSG00000089094 MIM:609078; AllianceGenome:HGNC:13610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 6.6), appendix (RPKM 5.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q24.31
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121408461..121582279, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121399894..121575445, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121866899..122018928, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121773208-121773399 Neighboring gene anaphase promoting complex subunit 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121789289-121789964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121790641-121791316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121791317-121791990 Neighboring gene uncharacterized LOC124903037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7164 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:121838029-121838560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121838561-121839092 Neighboring gene MPRA-validated peak2014 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7165 Neighboring gene ring finger protein 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121886380-121886880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121886881-121887381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121889913-121890727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121890728-121891541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4974 Neighboring gene microRNA 7107 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:121913999-121914826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121925323-121925834 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:121928205-121928918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121937748-121938447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121938448-121939146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121940397-121940896 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121951587-121951880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121953080-121953588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121953589-121954095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121956373-121956946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121967403-121967904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121971375-121972045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121973358-121974150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:121984877-121985582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121987013-121987514 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122014140-122014717 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:122014718-122015296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4977 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122018218-122019153 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122020089-122021024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122021025-122021958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122028863-122029678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122029679-122030494 Neighboring gene KDM2B divergent transcript Neighboring gene RNA, U6 small nuclear 1004, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4980 Neighboring gene Sharpr-MPRA regulatory region 5022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122062776-122063276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122070465-122071345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122076353-122076870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122076871-122077388 Neighboring gene ORAI calcium release-activated calcium modulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature. van Jaarsveld RH, et al. Genet Med, 2023 Jan. PMID 36322151, Free PMC Article
    2. Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors. Sasaki Y, et al. Biochem Biophys Res Commun, 2022 May 21. PMID 35306360
    3. Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. Xie Z, et al. Bioengineered, 2021 Dec. PMID 34783291, Free PMC Article
    4. KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial-mesenchymal transition in lung and pancreatic cancer cell lines. Wanna-Udom S, et al. J Biol Chem, 2021 Jan-Jun. PMID 33779563, Free PMC Article
    5. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification. Yuan W, et al. Int J Biol Sci, 2021. PMID 33613110, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.
      Title: Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.
    2. The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma.
      Title: The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma.
    3. KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.
      Title: KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.
    4. Biological Functions of the KDM2 Family of Histone Demethylases.
      Title: Biological Functions of the KDM2 Family of Histone Demethylases.
    5. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.
      Title: Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.
    6. KDM2B mediates the Wnt/beta-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
      Title: KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
    7. Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.
      Title: Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors.
    8. Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.
      Title: Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.
    9. SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation.
      Title: SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation.
    10. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification.
      Title: The histone demethylase KDM2B regulates human primordial germ cell-like cells specification.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36me/H3K36me2 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone demethylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unmethylated CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryonic camera-type eye morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in forebrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fourth ventricle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hindbrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in initiation of neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lateral ventricle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in midbrain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in midbrain-hindbrain boundary morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in third ventricle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    lysine-specific demethylase 2B
    Names
    CXXC-type zinc finger protein 2
    F-box and leucine-rich repeat protein 10
    F-box protein FBL10
    F-box/LRR-repeat protein 10
    JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
    [Histone-H3]-lysine-36 demethylase 1B
    jmjC domain-containing histone demethylation protein 1B
    jumonji C domain-containing histone demethylase 1B
    lysine (K)-specific demethylase 2B
    protein-containing CXXC domain 2
    NP_001005366.1
    NP_115979.3
    XP_005254012.1
    XP_005254013.1
    XP_005254018.1
    XP_011537169.2
    XP_011537177.1
    XP_047285637.1
    XP_047285638.1
    XP_047285639.1
    XP_047285640.1
    XP_047285641.1
    XP_047285642.1
    XP_047285643.1
    XP_047285644.1
    XP_047285645.1
    XP_047285646.1
    XP_047285647.1
    XP_047285648.1
    XP_047285649.1
    XP_047285650.1
    XP_047285651.1
    XP_047285652.1
    XP_047285653.1
    XP_047285654.1
    XP_047285655.1
    XP_047285656.1
    XP_047285657.1
    XP_047285658.1
    XP_047285659.1
    XP_047285660.1
    XP_047285661.1
    XP_047285662.1
    XP_047285663.1
    XP_047285664.1
    XP_047285665.1
    XP_047285666.1
    XP_047285667.1
    XP_047285668.1
    XP_047285669.1
    XP_047285670.1
    XP_047285671.1
    XP_047285672.1
    XP_047285673.1
    XP_047285674.1
    XP_047285675.1
    XP_047285676.1
    XP_047285677.1
    XP_047285678.1
    XP_047285679.1
    XP_054229477.1
    XP_054229478.1
    XP_054229479.1
    XP_054229480.1
    XP_054229481.1
    XP_054229482.1
    XP_054229483.1
    XP_054229484.1
    XP_054229485.1
    XP_054229486.1
    XP_054229487.1
    XP_054229488.1
    XP_054229489.1
    XP_054229490.1
    XP_054229491.1
    XP_054229492.1
    XP_054229493.1
    XP_054229494.1
    XP_054229495.1
    XP_054229496.1
    XP_054229497.1
    XP_054229498.1
    XP_054229499.1
    XP_054229500.1
    XP_054229501.1
    XP_054229502.1
    XP_054229503.1
    XP_054229504.1
    XP_054229505.1
    XP_054229506.1
    XP_054229507.1
    XP_054229508.1
    XP_054229509.1
    XP_054229510.1
    XP_054229511.1
    XP_054229512.1
    XP_054229513.1
    XP_054229514.1
    XP_054229515.1
    XP_054229516.1
    XP_054229517.1
    XP_054229518.1
    XP_054229519.1
    XP_054229520.1
    XP_054229521.1
    XP_054229522.1
    XP_054229523.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033820.2 RefSeqGene

      Range
      6256..158183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005366.2 → NP_001005366.1  lysine-specific demethylase 2B isoform b

      See identical proteins and their annotated locations for NP_001005366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and coding region, as compared to variant 1. The encoded isoform b has alternate N- and C-termini and lacks an internal segment, as compared to isoform a.
      Source sequence(s)
      AA504464, AK127328, BC028612
      Consensus CDS
      CCDS41849.1
      UniProtKB/Swiss-Prot
      Q8NHM5
      Related
      ENSP00000366269.3, ENST00000377069.8
      Conserved Domains (7) summary
      cd09293
      Location:1049 → 1238
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:584 → 620
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1033 → 1057
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:630 → 691
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:999 → 1039
      F-box-like; F-box-like
      cl21464
      Location:198 → 304
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_032590.5 → NP_115979.3  lysine-specific demethylase 2B isoform a

      See identical proteins and their annotated locations for NP_115979.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC145422, AJ459424, AK027692, BX648928, CA430876
      Consensus CDS
      CCDS41850.1
      UniProtKB/Swiss-Prot
      A8MRS1, Q1RLM7, Q8NCI2, Q8NHM5, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75
      Related
      ENSP00000366271.3, ENST00000377071.9
      Conserved Domains (7) summary
      cd09293
      Location:1118 → 1307
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:182 → 257
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:615 → 651
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1102 → 1126
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:661 → 722
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:1068 → 1108
      F-box-like; F-box-like
      cl21464
      Location:229 → 335
      cupin_like; Conserved domain found in cupin and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      121408461..121582279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429682.1 → XP_047285638.1  lysine-specific demethylase 2B isoform X3

    2. XM_047429681.1 → XP_047285637.1  lysine-specific demethylase 2B isoform X2

    3. XM_011538867.4 → XP_011537169.2  lysine-specific demethylase 2B isoform X1

    4. XM_047429684.1 → XP_047285640.1  lysine-specific demethylase 2B isoform X5

    5. XM_047429683.1 → XP_047285639.1  lysine-specific demethylase 2B isoform X4

    6. XM_047429696.1 → XP_047285652.1  lysine-specific demethylase 2B isoform X17

    7. XM_047429690.1 → XP_047285646.1  lysine-specific demethylase 2B isoform X11

    8. XM_047429688.1 → XP_047285644.1  lysine-specific demethylase 2B isoform X9

    9. XM_047429707.1 → XP_047285663.1  lysine-specific demethylase 2B isoform X30

    10. XM_047429706.1 → XP_047285662.1  lysine-specific demethylase 2B isoform X29

    11. XM_047429716.1 → XP_047285672.1  lysine-specific demethylase 2B isoform X39

    12. XM_047429717.1 → XP_047285673.1  lysine-specific demethylase 2B isoform X39

    13. XM_047429708.1 → XP_047285664.1  lysine-specific demethylase 2B isoform X31

    14. XM_047429699.1 → XP_047285655.1  lysine-specific demethylase 2B isoform X20

    15. XM_047429698.1 → XP_047285654.1  lysine-specific demethylase 2B isoform X19

    16. XM_047429691.1 → XP_047285647.1  lysine-specific demethylase 2B isoform X12

    17. XM_047429693.1 → XP_047285649.1  lysine-specific demethylase 2B isoform X14

      UniProtKB/Swiss-Prot
      A8MRS1, Q1RLM7, Q8NCI2, Q8NHM5, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75

    18. XM_047429705.1 → XP_047285661.1  lysine-specific demethylase 2B isoform X28

    19. XM_047429703.1 → XP_047285659.1  lysine-specific demethylase 2B isoform X26

    20. XM_047429692.1 → XP_047285648.1  lysine-specific demethylase 2B isoform X13

    21. XM_047429689.1 → XP_047285645.1  lysine-specific demethylase 2B isoform X10

    22. XM_047429687.1 → XP_047285643.1  lysine-specific demethylase 2B isoform X8

    23. XM_047429686.1 → XP_047285642.1  lysine-specific demethylase 2B isoform X7

    24. XM_047429685.1 → XP_047285641.1  lysine-specific demethylase 2B isoform X6

    25. XM_047429700.1 → XP_047285656.1  lysine-specific demethylase 2B isoform X21

    26. XM_047429709.1 → XP_047285665.1  lysine-specific demethylase 2B isoform X32

    27. XM_047429702.1 → XP_047285658.1  lysine-specific demethylase 2B isoform X24

    28. XM_005253955.5 → XP_005254012.1  lysine-specific demethylase 2B isoform X22

      Conserved Domains (7) summary
      cd09293
      Location:1087 → 1276
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:584 → 620
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1071 → 1095
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:630 → 691
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:1037 → 1077
      F-box-like; F-box-like
      cl21464
      Location:198 → 304
      cupin_like; Conserved domain found in cupin and related proteins

    29. XM_047429694.1 → XP_047285650.1  lysine-specific demethylase 2B isoform X15

    30. XM_047429701.1 → XP_047285657.1  lysine-specific demethylase 2B isoform X23

    31. XM_047429711.1 → XP_047285667.1  lysine-specific demethylase 2B isoform X34

    32. XM_047429710.1 → XP_047285666.1  lysine-specific demethylase 2B isoform X33

    33. XM_047429704.1 → XP_047285660.1  lysine-specific demethylase 2B isoform X27

    34. XM_005253956.5 → XP_005254013.1  lysine-specific demethylase 2B isoform X25

      Conserved Domains (7) summary
      cd09293
      Location:1081 → 1270
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145 → 220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:578 → 614
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1065 → 1089
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:624 → 685
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:1031 → 1071
      F-box-like; F-box-like
      cl21464
      Location:192 → 298
      cupin_like; Conserved domain found in cupin and related proteins

    35. XM_047429695.1 → XP_047285651.1  lysine-specific demethylase 2B isoform X16

    36. XM_047429697.1 → XP_047285653.1  lysine-specific demethylase 2B isoform X18

    37. XM_047429713.1 → XP_047285669.1  lysine-specific demethylase 2B isoform X36

    38. XM_047429715.1 → XP_047285671.1  lysine-specific demethylase 2B isoform X38

    39. XM_047429714.1 → XP_047285670.1  lysine-specific demethylase 2B isoform X37

    40. XM_047429712.1 → XP_047285668.1  lysine-specific demethylase 2B isoform X35

    41. XM_047429719.1 → XP_047285675.1  lysine-specific demethylase 2B isoform X40

    42. XM_047429720.1 → XP_047285676.1  lysine-specific demethylase 2B isoform X41

    43. XM_047429718.1 → XP_047285674.1  lysine-specific demethylase 2B isoform X40

    44. XM_047429723.1 → XP_047285679.1  lysine-specific demethylase 2B isoform X46

    45. XM_047429722.1 → XP_047285678.1  lysine-specific demethylase 2B isoform X45

    46. XM_047429721.1 → XP_047285677.1  lysine-specific demethylase 2B isoform X44

    47. XM_005253961.6 → XP_005254018.1  lysine-specific demethylase 2B isoform X43

      UniProtKB/TrEMBL
      B7ZB05
      Related
      ENSP00000437821.1, ENST00000542973.5
      Conserved Domains (5) summary
      cd09293
      Location:558 → 747
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:55 → 91
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:542 → 566
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101 → 162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:508 → 548
      F-box-like; F-box-like

    48. XM_011538875.4 → XP_011537177.1  lysine-specific demethylase 2B isoform X42

      See identical proteins and their annotated locations for XP_011537177.1

      UniProtKB/TrEMBL
      B4DSN4, B7ZB05
      Conserved Domains (5) summary
      cd09293
      Location:561 → 750
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:55 → 91
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:545 → 569
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101 → 162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:511 → 551
      F-box-like; F-box-like

    RNA

    1. XR_007063140.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      121399894..121575445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373505.1 → XP_054229480.1  lysine-specific demethylase 2B isoform X3

    2. XM_054373503.1 → XP_054229478.1  lysine-specific demethylase 2B isoform X2

    3. XM_054373502.1 → XP_054229477.1  lysine-specific demethylase 2B isoform X1

    4. XM_054373514.1 → XP_054229489.1  lysine-specific demethylase 2B isoform X48

    5. XM_054373507.1 → XP_054229482.1  lysine-specific demethylase 2B isoform X5

    6. XM_054373506.1 → XP_054229481.1  lysine-specific demethylase 2B isoform X4

    7. XM_054373511.1 → XP_054229486.1  lysine-specific demethylase 2B isoform X9

    8. XM_054373519.1 → XP_054229494.1  lysine-specific demethylase 2B isoform X17

    9. XM_054373513.1 → XP_054229488.1  lysine-specific demethylase 2B isoform X11

    10. XM_054373504.1 → XP_054229479.1  lysine-specific demethylase 2B isoform X47

    11. XM_054373532.1 → XP_054229507.1  lysine-specific demethylase 2B isoform X30

    12. XM_054373531.1 → XP_054229506.1  lysine-specific demethylase 2B isoform X29

    13. XM_054373522.1 → XP_054229497.1  lysine-specific demethylase 2B isoform X20

    14. XM_054373521.1 → XP_054229496.1  lysine-specific demethylase 2B isoform X19

    15. XM_054373533.1 → XP_054229508.1  lysine-specific demethylase 2B isoform X31

    16. XM_054373515.1 → XP_054229490.1  lysine-specific demethylase 2B isoform X12

    17. XM_054373530.1 → XP_054229505.1  lysine-specific demethylase 2B isoform X28

    18. XM_054373528.1 → XP_054229503.1  lysine-specific demethylase 2B isoform X26

    19. XM_054373516.1 → XP_054229491.1  lysine-specific demethylase 2B isoform X13

    20. XM_054373512.1 → XP_054229487.1  lysine-specific demethylase 2B isoform X10

    21. XM_054373510.1 → XP_054229485.1  lysine-specific demethylase 2B isoform X8

    22. XM_054373509.1 → XP_054229484.1  lysine-specific demethylase 2B isoform X7

    23. XM_054373508.1 → XP_054229483.1  lysine-specific demethylase 2B isoform X6

    24. XM_054373523.1 → XP_054229498.1  lysine-specific demethylase 2B isoform X49

    25. XM_054373525.1 → XP_054229500.1  lysine-specific demethylase 2B isoform X50

    26. XM_054373534.1 → XP_054229509.1  lysine-specific demethylase 2B isoform X32

    27. XM_054373526.1 → XP_054229501.1  lysine-specific demethylase 2B isoform X24

    28. XM_054373524.1 → XP_054229499.1  lysine-specific demethylase 2B isoform X22

    29. XM_054373517.1 → XP_054229492.1  lysine-specific demethylase 2B isoform X15

    30. XM_054373527.1 → XP_054229502.1  lysine-specific demethylase 2B isoform X25

    31. XM_054373529.1 → XP_054229504.1  lysine-specific demethylase 2B isoform X27

    32. XM_054373535.1 → XP_054229510.1  lysine-specific demethylase 2B isoform X33

    33. XM_054373536.1 → XP_054229511.1  lysine-specific demethylase 2B isoform X34

    34. XM_054373518.1 → XP_054229493.1  lysine-specific demethylase 2B isoform X16

    35. XM_054373520.1 → XP_054229495.1  lysine-specific demethylase 2B isoform X18

    36. XM_054373538.1 → XP_054229513.1  lysine-specific demethylase 2B isoform X36

    37. XM_054373540.1 → XP_054229515.1  lysine-specific demethylase 2B isoform X38

    38. XM_054373539.1 → XP_054229514.1  lysine-specific demethylase 2B isoform X37

    39. XM_054373537.1 → XP_054229512.1  lysine-specific demethylase 2B isoform X35

    40. XM_054373542.1 → XP_054229517.1  lysine-specific demethylase 2B isoform X40

    41. XM_054373541.1 → XP_054229516.1  lysine-specific demethylase 2B isoform X40

    42. XM_054373543.1 → XP_054229518.1  lysine-specific demethylase 2B isoform X41

    43. XM_054373546.1 → XP_054229521.1  lysine-specific demethylase 2B isoform X44

    44. XM_054373545.1 → XP_054229520.1  lysine-specific demethylase 2B isoform X43

    45. XM_054373548.1 → XP_054229523.1  lysine-specific demethylase 2B isoform X46

    46. XM_054373547.1 → XP_054229522.1  lysine-specific demethylase 2B isoform X45

    47. XM_054373544.1 → XP_054229519.1  lysine-specific demethylase 2B isoform X42

      UniProtKB/TrEMBL
      B4DSN4

    RNA

    1. XR_008488704.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NHM5.1 GenPept UniProtKB/Swiss-Prot:Q8NHM5

    Gene LinkOut

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