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    CTNNA1 catenin alpha 1 [ Homo sapiens (human) ]

    Gene ID: 1495, updated on 5-May-2024

    Summary

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    Official Symbol
    CTNNA1provided by HGNC
    Official Full Name
    catenin alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:2509
    See related
    Ensembl:ENSG00000044115 MIM:116805; AllianceGenome:HGNC:2509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDBS2; MDPT2; CAP102
    Summary
    This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in esophagus (RPKM 69.8), lung (RPKM 58.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q31.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (138753425..138935034)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139279620..139461169)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138089114..138270723)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137946542-137947174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137945909-137946541 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L10a pseudogene 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137976937-137977490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:137977491-137978044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137986181-137986979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138001425-138001925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16402 Neighboring gene Sharpr-MPRA regulatory region 9755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23215 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:138089147-138089714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:138089715-138090281 Neighboring gene CTNNA1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138164188-138164688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138188550-138189082 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:138279886-138280098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138284538-138285402 Neighboring gene uncharacterized LOC124901079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138289067-138290004 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138346233-138346880 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene uncharacterized LOC124901080 Neighboring gene RNA, 5S ribosomal pseudogene 194

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments. Rangarajan ES, et al. Commun Biol, 2023 Mar 16. PMID 36928388, Free PMC Article
    2. First estimates of diffuse gastric cancer risks for carriers of CTNNA1 germline pathogenic variants. Coudert M, et al. J Med Genet, 2022 Dec. PMID 36038258
    3. Cancer predisposition and germline CTNNA1 variants. Lobo S, et al. Eur J Med Genet, 2021 Oct. PMID 34425242
    4. Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling. Bunker EN, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378218, Free PMC Article
    5. Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer. Felicio PS, et al. Hum Mutat, 2021 Mar. PMID 33326660, Free PMC Article

    See all (262) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct inter-domain interactions of dimeric versus monomeric alpha-catenin link cell junctions to filaments.
      Title: Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments.
    2. First estimates of diffuse gastric cancer risks for carriers of CTNNA1 germline pathogenic variants.
      Title: First estimates of diffuse gastric cancer risks for carriers of CTNNA1 germline pathogenic variants.
    3. Familial and hereditary gastric cancer, an overview.
      Title: Familial and hereditary gastric cancer, an overview.
    4. Clinical and Genetic Findings in CTNNA1-Associated Macular Pattern Dystrophy.
      Title: Clinical and Genetic Findings in CTNNA1-Associated Macular Pattern Dystrophy.
    5. Catenin alpha 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/beta-catenin signaling.
      Title: Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling.
    6. Cancer predisposition and germline CTNNA1 variants.
      Title: Cancer predisposition and germline CTNNA1 variants.
    7. Suppression of alpha-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-alpha autocrine/paracrine signaling.
      Title: Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling.
    8. Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer.
      Title: Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer.
    9. Molecular mechanism for direct actin force-sensing by alpha-catenin.
      Title: Molecular mechanism for direct actin force-sensing by α-catenin.
    10. Salivary Secretory Carcinoma Harboring a Novel ALK Fusion: Expanding the Molecular Characterization of Carcinomas Beyond the ETV6 Gene.
      Title: Salivary Secretory Carcinoma Harboring a Novel ALK Fusion: Expanding the Molecular Characterization of Carcinomas Beyond the ETV6 Gene.
    Submit: New GeneRIF Correction See all GeneRIFs (75)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Patterned macular dystrophy 2
    MedGen: C1837029 OMIM: 608970 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2022-10-12)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2022-10-12)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 and alpha-catenin co-localize in gp160 and GST-alpha-catenin expressing cells; the leucine zipper-like domain (gp160 residues 791-824) of gp41 interacts strongly with the carboxy terminus (residues 795-906) of alpha-catenin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36832, FLJ52416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vinculin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apical junction assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in axon regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to indole-3-methanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epithelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gap junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of flotillin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in zonula adherens IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    catenin alpha-1
    Names
    alpha-E-catenin
    catenin (cadherin-associated protein), alpha 1, 102kDa
    epididymis secretory sperm binding protein
    renal carcinoma antigen NY-REN-13

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047029.1 RefSeqGene

      Range
      5030..186639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290307.3 → NP_001277236.1  catenin alpha-1 isoform 2

      See identical proteins and their annotated locations for NP_001277236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI078507, BC000385, DC369291, U03100
      Consensus CDS
      CCDS78064.1
      UniProtKB/TrEMBL
      B4E2G8, G3XAM7
      Related
      ENSP00000486200.1, ENST00000627109.2
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 811
      Vinculin; Vinculin family

    2. NM_001290309.3 → NP_001277238.1  catenin alpha-1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI078507, AK296708, AK300439, BC000385, DC369291
      UniProtKB/TrEMBL
      B4DU00
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 764
      Vinculin; Vinculin family

    3. NM_001290310.3 → NP_001277239.1  catenin alpha-1 isoform 4

      See identical proteins and their annotated locations for NP_001277239.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon and another at the 5' end of the next exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI078507, AK296708, BC000385
      UniProtKB/TrEMBL
      B4DKT9, B4DU00
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 744
      Vinculin; Vinculin family

    4. NM_001290312.1 → NP_001277241.1  catenin alpha-1 isoform 5

      See identical proteins and their annotated locations for NP_001277241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in place of the first seven exons compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (5) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI078507, BC000385, BC031262, DA349847
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Related
      ENSP00000438476.1, ENST00000540387.5
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    5. NM_001323982.2 → NP_001310911.1  catenin alpha-1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011405, AC034243
      Consensus CDS
      CCDS34243.1
      UniProtKB/Swiss-Prot
      P35221, Q12795, Q8N1C0
      UniProtKB/TrEMBL
      A0A384MDY0, B4E2G8
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    6. NM_001323983.1 → NP_001310912.1  catenin alpha-1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011405, AC034243
      Consensus CDS
      CCDS34243.1
      UniProtKB/Swiss-Prot
      P35221, Q12795, Q8N1C0
      UniProtKB/TrEMBL
      A0A384MDY0, B4E2G8
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    7. NM_001323984.2 → NP_001310913.1  catenin alpha-1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011405, AC034243
      Consensus CDS
      CCDS34243.1
      UniProtKB/Swiss-Prot
      P35221, Q12795, Q8N1C0
      UniProtKB/TrEMBL
      A0A384MDY0, B4E2G8
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    8. NM_001323985.2 → NP_001310914.1  catenin alpha-1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011405, AC034243
      UniProtKB/TrEMBL
      B4E2G8

    9. NM_001323986.2 → NP_001310915.1  catenin alpha-1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011405, AC034243
      UniProtKB/TrEMBL
      B4E2G8

    10. NM_001323987.1 → NP_001310916.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    11. NM_001323988.1 → NP_001310917.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    12. NM_001323989.1 → NP_001310918.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    13. NM_001323990.1 → NP_001310919.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    14. NM_001323991.1 → NP_001310920.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    15. NM_001323992.1 → NP_001310921.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    16. NM_001323993.1 → NP_001310922.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    17. NM_001323994.1 → NP_001310923.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    18. NM_001323995.1 → NP_001310924.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    19. NM_001323996.1 → NP_001310925.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    20. NM_001323997.1 → NP_001310926.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    21. NM_001323998.1 → NP_001310927.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    22. NM_001323999.1 → NP_001310928.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    23. NM_001324000.1 → NP_001310929.1  catenin alpha-1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Consensus CDS
      CCDS75315.1
      UniProtKB/TrEMBL
      B3KSR8
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 497
      Vinculin; Vinculin family

    24. NM_001324001.1 → NP_001310930.1  catenin alpha-1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011405
      UniProtKB/TrEMBL
      B3KSR8

    25. NM_001324002.1 → NP_001310931.1  catenin alpha-1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011405

    26. NM_001324003.1 → NP_001310932.1  catenin alpha-1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011405

    27. NM_001324004.1 → NP_001310933.1  catenin alpha-1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011405

    28. NM_001324005.1 → NP_001310934.1  catenin alpha-1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011405

    29. NM_001324006.1 → NP_001310935.1  catenin alpha-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 384
      Vinculin; Vinculin family

    30. NM_001324007.1 → NP_001310936.1  catenin alpha-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 384
      Vinculin; Vinculin family

    31. NM_001324008.1 → NP_001310937.1  catenin alpha-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 384
      Vinculin; Vinculin family

    32. NM_001324009.1 → NP_001310938.1  catenin alpha-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 384
      Vinculin; Vinculin family

    33. NM_001324010.1 → NP_001310939.1  catenin alpha-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 384
      Vinculin; Vinculin family

    34. NM_001324011.1 → NP_001310940.1  catenin alpha-1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011405
      UniProtKB/TrEMBL
      B3KSR8

    35. NM_001324012.1 → NP_001310941.1  catenin alpha-1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 416
      Vinculin; Vinculin family

    36. NM_001324013.1 → NP_001310942.1  catenin alpha-1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011405
      Conserved Domains (1) summary
      pfam01044
      Location:1 → 416
      Vinculin; Vinculin family

    37. NM_001903.5 → NP_001894.2  catenin alpha-1 isoform 1

      See identical proteins and their annotated locations for NP_001894.2

      Status: REVIEWED

      Source sequence(s)
      AI078507, BC000385, DC369291
      Consensus CDS
      CCDS34243.1
      UniProtKB/Swiss-Prot
      P35221, Q12795, Q8N1C0
      UniProtKB/TrEMBL
      A0A384MDY0, B4E2G8
      Related
      ENSP00000304669.7, ENST00000302763.12
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      138753425..138935034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139279620..139461169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351718.1 → XP_054207693.1  catenin alpha-1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35221.1 GenPept UniProtKB/Swiss-Prot:P35221

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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