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    OSCAR osteoclast associated Ig-like receptor [ Homo sapiens (human) ]

    Gene ID: 126014, updated on 11-Apr-2024

    Summary

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    Official Symbol
    OSCARprovided by HGNC
    Official Full Name
    osteoclast associated Ig-like receptorprovided by HGNC
    Primary source
    HGNC:HGNC:29960
    See related
    Ensembl:ENSG00000170909 MIM:606862; AllianceGenome:HGNC:29960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIGR3; PIgR-3
    Summary
    Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54094668..54100803, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57173230..57179492, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54597933..54604094, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54605952-54606928 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54617323-54618196 Neighboring gene TCF3 fusion partner Neighboring gene PRPF31 antisense RNA 1 Neighboring gene pre-mRNA processing factor 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women. Wang D, et al. Clin Exp Pharmacol Physiol, 2020 Aug. PMID 32246488
    2. OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis. Schultz HS, et al. Eur J Immunol, 2016 Apr. PMID 26786702
    3. Structural basis for collagen recognition by the immune receptor OSCAR. Zhou L, et al. Blood, 2016 Feb 4. PMID 26552697, Free PMC Article
    4. OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. Barrow AD, et al. J Immunol, 2015 Apr 1. PMID 25716998, Free PMC Article
    5. Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk. Ndongo-Thiam N, et al. Ann Rheum Dis, 2014 Jun. PMID 24448348

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women.
      Title: Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women.
    2. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
      Title: Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
    3. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts
      Title: Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro.
    4. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis.
      Title: OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis.
    5. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1.
      Title: Structural basis for collagen recognition by the immune receptor OSCAR.
    6. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes.
      Title: OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.
    7. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients.
      Title: The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints.
    8. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA.
      Title: Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk.
    9. Rotative stress in mouse cells results in increased levels of Oscar transcription.
      Title: The effect of rotative stress on CAII, FAS, FASL, OSCAR, and TRAP gene expression in osteoclasts.
    10. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion.
      Title: Quantitative proteomics reveals novel functions of osteoclast-associated receptor in STAT signaling and cell adhesion in human endothelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables collagen receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    osteoclast-associated immunoglobulin-like receptor
    Names
    osteoclast associated receptor OSCAR-S1
    osteoclast associated receptor OSCAR-S2
    osteoclast associated, immunoglobulin-like receptor
    poly-Ig receptor 3
    polymeric immunoglobulin receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282349.3 → NP_001269278.1  osteoclast-associated immunoglobulin-like receptor isoform 6 precursor

      See identical proteins and their annotated locations for NP_001269278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS74444.1
      UniProtKB/Swiss-Prot
      B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
      Related
      ENSP00000365808.2, ENST00000284648.10
      Conserved Domains (2) summary
      smart00410
      Location:38 → 100
      IG_like; Immunoglobulin like
      cl11960
      Location:31 → 124
      Ig; Immunoglobulin domain

    2. NM_001282350.3 → NP_001269279.1  osteoclast-associated immunoglobulin-like receptor isoform 7 precursor

      See identical proteins and their annotated locations for NP_001269279.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS62789.1
      UniProtKB/Swiss-Prot
      B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
      Related
      ENSP00000375641.1, ENST00000391761.5
      Conserved Domains (2) summary
      smart00410
      Location:27 → 89
      IG_like; Immunoglobulin like
      cl11960
      Location:20 → 113
      Ig; Immunoglobulin domain

    3. NM_130771.6 → NP_570127.3  osteoclast-associated immunoglobulin-like receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12873.1
      UniProtKB/TrEMBL
      A0A087X1R2, A0A0G2JMM7
      Related
      ENSP00000348927.3, ENST00000356532.7
      Conserved Domains (2) summary
      smart00410
      Location:42 → 104
      IG_like; Immunoglobulin like
      cl11960
      Location:35 → 128
      Ig; Immunoglobulin domain

    4. NM_133168.6 → NP_573398.2  osteoclast-associated immunoglobulin-like receptor isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12874.1
      UniProtKB/TrEMBL
      A0A0A0MR14, A0A0G2JMM7
      Related
      ENSP00000304523.5, ENST00000351806.8
      Conserved Domains (2) summary
      smart00410
      Location:27 → 89
      IG_like; Immunoglobulin like
      cl11960
      Location:20 → 113
      Ig; Immunoglobulin domain

    5. NM_133169.6 → NP_573399.2  osteoclast-associated immunoglobulin-like receptor isoform 4 precursor

      See identical proteins and their annotated locations for NP_573399.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12875.1
      UniProtKB/TrEMBL
      A0A0A0MRF2, A0A0G2JMM7
      Related
      ENSP00000351145.4, ENST00000358375.9
      Conserved Domains (2) summary
      smart00410
      Location:38 → 100
      IG_like; Immunoglobulin like
      cl11960
      Location:31 → 124
      Ig; Immunoglobulin domain

    6. NM_206818.4 → NP_996554.2  osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12876.1
      UniProtKB/Swiss-Prot
      B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
      UniProtKB/TrEMBL
      A0A087WV17
      Related
      ENSP00000352671.4, ENST00000359649.8
      Conserved Domains (2) summary
      smart00410
      Location:42 → 104
      IG_like; Immunoglobulin like
      cl11960
      Location:35 → 128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54094668..54100803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      69046..75207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57173230..57179492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_206817.1: Suppressed sequence

      Description
      NM_206817.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYS5.3 GenPept UniProtKB/Swiss-Prot:Q8IYS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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