SLC22A17 solute carrier family 22 member 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC22A17provided by HGNC
Official Full Name: solute carrier family 22 member 17provided by HGNC
Primary source: HGNC:HGNC:23095
See related: Ensembl:ENSG00000092096 MIM:611461; AllianceGenome:HGNC:23095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3
Summary: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Is integral component of organelle membrane and integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 47.7), prostate (RPKM 11.1) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (23346311..23352887, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (17547327..17553903, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (23815520..23822096, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.
Title: The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.
Identification of immune cells and mRNA associated with prognosis of gastric cancer.
Title: Identification of immune cells and mRNA associated with prognosis of gastric cancer.
Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples.
Title: The expression analysis of NGAL and NGALR in clear cell renal cell carcinoma.
Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17.
Title: Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17.
Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity.
Title: Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence
Title: Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress.
No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group.
Title: [Correlation of lipocalin-2 and its receptor expressions with preeclampsia].
NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma.
Title: NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification.
This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome.
Title: NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis.
These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells.
Title: Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-15014 (e-PCR)
- UniSTS:65793

WI-13550 (e-PCR)
- UniSTS:46796

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	TAS Traceable Author Statement more info
involved_in siderophore transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 17

Names: 24p3 receptor; NGAL receptor; brain-type organic cation transporter; lipocalin-2 receptor; neutrophil gelatinase-associated lipocalin receptor; potent brain type organic ion transporter; solute carrier family 22 (organic cation transporter), member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289050.1 → NP_001275979.1 solute carrier family 22 member 17 isoform c

See identical proteins and their annotated locations for NP_001275979.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon and an alternate in-frame splice junction at the 3' end of another exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.

Source sequence(s)

AK308661, BC020565, BF345519, DQ658848

UniProtKB/Swiss-Prot

Q8WUG5

Conserved Domains (1) summary

cl28910
Location:88 → 258

MFS; Major Facilitator Superfamily
NM_016609.7 → NP_057693.4 solute carrier family 22 member 17 isoform b

Status: VALIDATED

Source sequence(s)

AL049829

Consensus CDS

CCDS9594.3

Related

ENSP00000346824.5, ENST00000354772.10

Conserved Domains (1) summary

cd17445
Location:174 → 587

MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily
NM_020372.4 → NP_065105.3 solute carrier family 22 member 17 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AL049829

Consensus CDS

CCDS9593.2

UniProtKB/Swiss-Prot

A0A1C7CYV9, A4UA13, A8MUT0, Q2TAB0, Q5BKY8, Q86U04, Q8WUG5, Q9H1D3, Q9NQD5

Related

ENSP00000380437.2, ENST00000397267.6

Conserved Domains (1) summary

cd17445
Location:174 → 605

MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

RNA

NR_110290.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate internal exons and uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC030559, BI758221

Related

ENST00000474057.6