U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TIGD2 tigger transposable element derived 2 [ Homo sapiens (human) ]

    Gene ID: 166815, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TIGD2provided by HGNC
    Official Full Name
    tigger transposable element derived 2provided by HGNC
    Primary source
    HGNC:HGNC:18333
    See related
    Ensembl:ENSG00000180346 MIM:612973; AllianceGenome:HGNC:18333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEL106
    Summary
    The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TIGD2 in Genome Data Viewer
    Location:
    4q22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (89111169..89114901)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (92442241..92445972)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (90032320..90036052)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 13 member A Neighboring gene uncharacterized LOC124900732 Neighboring gene uncharacterized LOC105377327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:89908831-89909330 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:89928887-89930086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:89977637-89978199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15567 Neighboring gene RNA, U6 small nuclear 907, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:90074054-90074582 Neighboring gene uncharacterized LOC124900834

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Members of the pogo superfamily of DNA-mediated transposons in the human genome. Robertson HM. Mol Gen Genet, 1996 Oct 28. PMID 8917322
    2. Tiggers and DNA transposon fossils in the human genome. Smit AF, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643651, Free PMC Article
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
    5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • DKFZp667D1322

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tigger transposable element-derived protein 2
    Names
    epididymis luminal protein 106

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382380.1 → NP_001369309.1  tigger transposable element-derived protein 2

      Status: REVIEWED

      Source sequence(s)
      AC104785
      Consensus CDS
      CCDS3633.1
      UniProtKB/Swiss-Prot
      Q4W5G0
      UniProtKB/TrEMBL
      B3KNK0, V9HWD1
      Conserved Domains (3) summary
      pfam03184
      Location:207 → 385
      DDE_1; DDE superfamily endonuclease
      pfam03221
      Location:76 → 135
      HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
      cl21459
      Location:4 → 52
      HTH; Helix-turn-helix domains

    2. NM_145715.3 → NP_663761.1  tigger transposable element-derived protein 2

      See identical proteins and their annotated locations for NP_663761.1

      Status: REVIEWED

      Source sequence(s)
      AC104785
      Consensus CDS
      CCDS3633.1
      UniProtKB/Swiss-Prot
      Q4W5G0
      UniProtKB/TrEMBL
      B3KNK0, V9HWD1
      Related
      ENSP00000486687.1, ENST00000603357.3
      Conserved Domains (3) summary
      pfam03184
      Location:207 → 385
      DDE_1; DDE superfamily endonuclease
      pfam03221
      Location:76 → 135
      HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
      cl21459
      Location:4 → 52
      HTH; Helix-turn-helix domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      89111169..89114901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      92442241..92445972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4W5G0.1 GenPept UniProtKB/Swiss-Prot:Q4W5G0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous