MEOX1 mesenchyme homeobox 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MEOX1provided by HGNC
Official Full Name: mesenchyme homeobox 1provided by HGNC
Primary source: HGNC:HGNC:7013
See related: Ensembl:ENSG00000005102 MIM:600147; AllianceGenome:HGNC:7013
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KFS2; MOX1
Summary: This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in fat (RPKM 15.6), heart (RPKM 8.2) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (43640389..43661922, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (44492923..44514459, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (41717757..41739290, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1.
Title: Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1.
Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4[+] T cells.
Title: Identification of the novel FOXP3-dependent T(reg) cell transcription factor MEOX1 by high-dimensional analysis of human CD4(+) T cells.
MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell-cycle checkpoint gene CCNB1.
Title: MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell-cycle checkpoint gene CCNB1.
A transcriptional switch governs fibroblast activation in heart disease.
Title: A transcriptional switch governs fibroblast activation in heart disease.
Characterization of the proteome and metabolome of human liver sinusoidal endothelial-like cells derived from induced pluripotent stem cells.
Title: Characterization of the proteome and metabolome of human liver sinusoidal endothelial-like cells derived from induced pluripotent stem cells.
Mesenchyme homeobox 1 mediated-promotion of osteoblastic differentiation is negatively regulated by mir-3064-5p.
Title: Mesenchyme homeobox 1 mediated-promotion of osteoblastic differentiation is negatively regulated by mir-3064-5p.
Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations.
Title: Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations.
Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer.
Title: Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer.
The expression of Meox1 protein in the scar tissue was significantly higher than that in normal skin of patients with hypertrophic scars.
Title: [Mechanism of transcriptional regulation of Meox1 by transforming growth factor β (1) and its effect on cell migration of adult human dermal fibroblasts].
high levels of MEOX1 especially nuclear staining was an independent prognostic factor for non-small-cell lung cancer
Title: MEOX1 Promotes Tumor Progression and Predicts Poor Prognosis in Human Non-Small-Cell Lung Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Klippel-Feil syndrome 2, autosomal recessive MedGen: C1859209 OMIM: 214300 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482089

SGC35253 (e-PCR)
- UniSTS:43593

GDB:438128 (e-PCR)
- UniSTS:157269

GDB:438129 (e-PCR)
- UniSTS:157270

GDB:438132 (e-PCR)
- UniSTS:157271

GDB:438137 (e-PCR)
- UniSTS:157272

NoName (e-PCR)
- UniSTS:481122

NoName (e-PCR)
- UniSTS:490411

D17S965 (e-PCR)
- UniSTS:148664

D17S680 (e-PCR)
- UniSTS:147129

D17S1171 (e-PCR)
- UniSTS:149433

D17S1339 (e-PCR)
- UniSTS:150224

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables HMG box domain binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in hematopoietic stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sclerotome development	ISS Inferred from Sequence or Structural Similarity more info
involved_in somite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in somite development	ISS Inferred from Sequence or Structural Similarity more info
involved_in somite specification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: homeobox protein MOX-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032987.1 RefSeqGene

Range

4973..26506

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_708

mRNA and Protein(s)

NM_001040002.2 → NP_001035091.1 homeobox protein MOX-1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region (compared to variant 1), resulting in a protein that maintains the reading frame but is shorter at the N- terminus, compared to isoform 1.

Source sequence(s)

AC004149, AW410297, BE898972, BQ003431, BQ028272, BX284090, U10492

Consensus CDS

CCDS42343.1

UniProtKB/Swiss-Prot

P50221

Related

ENSP00000377271.2, ENST00000393661.2

Conserved Domains (1) summary

pfam00046
Location:60 → 112

Homeobox; Homeobox domain
NM_004527.4 → NP_004518.1 homeobox protein MOX-1 isoform 1

See identical proteins and their annotated locations for NP_004518.1

Status: REVIEWED

Description

Transcript Variant: This variant represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC004149, BG677020, BQ028272, U10492

Consensus CDS

CCDS11466.1

UniProtKB/Swiss-Prot

A8K524, A8MWF9, P50221, Q15069

Related

ENSP00000321684.4, ENST00000318579.9

Conserved Domains (1) summary

pfam00046
Location:175 → 227

Homeobox; Homeobox domain
NM_013999.4 → NP_054705.1 homeobox protein MOX-1 isoform 2

See identical proteins and their annotated locations for NP_054705.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region that results in a frameshift and a premature stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC004149, BG677020, BQ028272, U10493

Consensus CDS

CCDS11467.1

UniProtKB/Swiss-Prot

P50221

Related

ENSP00000449049.2, ENST00000549132.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

43640389..43661922 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524818.3 → XP_011523120.1 homeobox protein MOX-1 isoform X1

Conserved Domains (1) summary

pfam00046
Location:175 → 216

Homeobox; Homeobox domain