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    FOXS1 forkhead box S1 [ Homo sapiens (human) ]

    Gene ID: 2307, updated on 7-Apr-2024

    Summary

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    Official Symbol
    FOXS1provided by HGNC
    Official Full Name
    forkhead box S1provided by HGNC
    Primary source
    HGNC:HGNC:3735
    See related
    Ensembl:ENSG00000179772 MIM:602939; AllianceGenome:HGNC:3735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKHL18; FREAC10
    Summary
    The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
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    Genomic context

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    See FOXS1 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31844303..31845604, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33568911..33570212, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30432106..30433407, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17699 Neighboring gene TPX2 microtubule nucleation factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30373423-30373922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30376059-30376558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30403487-30404289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30407643-30408184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411041-30411568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411569-30412095 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30412296-30412796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30414489-30414989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30421849-30422479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30424845-30425692 Neighboring gene myosin light chain kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30432791-30433348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12766 Neighboring gene dual specificity phosphatase 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30467121-30467620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12770 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17702 Neighboring gene Sharpr-MPRA regulatory region 918 Neighboring gene RNA, U1 small nuclear 94, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17704 Neighboring gene p53 and DNA damage regulated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway to regulate colorectal cancer progression. Zhang L, et al. J Transl Med, 2022 Jul 21. PMID 35864528, Free PMC Article
    2. Overexpression of FOXS1 in gastric cancer cell lines inhibits proliferation, metastasis, and epithelial-mesenchymal transition of tumor through downregulating wnt/β-catenin pathway. Lu Q, et al. J Cell Biochem, 2019 Mar. PMID 30500980
    3. Comparative genomics of vertebrate Fox cluster loci. Wotton KR, et al. BMC Genomics, 2006 Oct 24. PMID 17062144, Free PMC Article
    4. Forkhead Box S1 inhibits the progression of lung squamous cell carcinoma cells by mediating Wnt/β-catenin pathway. Wang F, et al. Chin J Physiol, 2022 Sep-Oct. PMID 36308082
    5. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. Cederberg A, et al. Genomics, 1997 Sep 15. PMID 9325056

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXS1 is increased in liver fibrosis and regulates TGFbeta responsiveness and proliferation pathways in human hepatic stellate cells.
      Title: FOXS1 is increased in liver fibrosis and regulates TGFβ responsiveness and proliferation pathways in human hepatic stellate cells.
    2. FOXS1 promotes prostate cancer progression through the Hedgehog/Gli1 pathway.
      Title: FOXS1 promotes prostate cancer progression through the Hedgehog/Gli1 pathway.
    3. ERp44 Regulates the Proliferation, Migration, Invasion, and Apoptosis of Gastric Cancer Cells Via Activation of ER Stress.
      Title: ERp44 Regulates the Proliferation, Migration, Invasion, and Apoptosis of Gastric Cancer Cells Via Activation of ER Stress.
    4. Forkhead Box S1 inhibits the progression of lung squamous cell carcinoma cells by mediating Wnt/beta-catenin pathway.
      Title: Forkhead Box S1 inhibits the progression of lung squamous cell carcinoma cells by mediating Wnt/β-catenin pathway.
    5. Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/beta-catenin signaling pathway to regulate colorectal cancer progression.
      Title: Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway to regulate colorectal cancer progression.
    6. Study showed that FOXS1 expression is downregulated in gastric cancer tumors and cell lines promoting cell proliferation and metastasis through upregulation of wnt/beta-catenin pathway.
      Title: Overexpression of FOXS1 in gastric cancer cell lines inhibits proliferation, metastasis, and epithelial-mesenchymal transition of tumor through downregulating wnt/β-catenin pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC4544

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein S1
    Names
    FREAC-10
    forkhead-like 18 protein
    forkhead-related activator 10
    forkhead-related transcription factor 10
    forkhead-related transcription factor FREAC-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004118.4 → NP_004109.1  forkhead box protein S1

      See identical proteins and their annotated locations for NP_004109.1

      Status: REVIEWED

      Source sequence(s)
      BC013408
      Consensus CDS
      CCDS13192.1
      UniProtKB/Swiss-Prot
      O43638, Q96D28
      Related
      ENSP00000365145.3, ENST00000375978.5
      Conserved Domains (2) summary
      pfam00250
      Location:18 → 103
      Forkhead; Forkhead domain
      cl26386
      Location:116 → 313
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      31844303..31845604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      33568911..33570212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43638.2 GenPept UniProtKB/Swiss-Prot:O43638

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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