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    PLAGL2 PLAG1 like zinc finger 2 [ Homo sapiens (human) ]

    Gene ID: 5326, updated on 5-May-2024

    Summary

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    Official Symbol
    PLAGL2provided by HGNC
    Official Full Name
    PLAG1 like zinc finger 2provided by HGNC
    Primary source
    HGNC:HGNC:9047
    See related
    Ensembl:ENSG00000126003 MIM:604866; AllianceGenome:HGNC:9047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF900
    Summary
    Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 10.2), testis (RPKM 9.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLAGL2 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32192504..32207743, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33916427..33931666, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30780307..30795546, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30762883-30763484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30763485-30764084 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30768259-30768439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30769860-30770360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30776057-30776872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12777 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30779125-30779322 Neighboring gene testis specific protein Y-linked 26, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30784106-30784868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17712 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30795517-30796430 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene uncharacterized LOC124904884 Neighboring gene microRNA 1825

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway. Li Y, et al. Genes Genomics, 2023 Jan. PMID 36399309
    2. PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/β-catenin Pathway. Jin W, et al. Ann Clin Lab Sci, 2022 May. PMID 35777795
    3. Expression of PLAGL2 in bladder urothelial carcinoma and its relationship to lymph node metastasis and survival. Qu G, et al. Sci Rep, 2018 Apr 16. PMID 29662235, Free PMC Article
    4. Pleomorphic adenoma gene like-2 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human colorectal adenocarcinoma. Wang YP, et al. Oncol Rep, 2017 Apr. PMID 28259923, Free PMC Article
    5. Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer. Guo J, et al. PLoS One, 2016. PMID 27537362, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.
      Title: POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.
    2. PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
      Title: PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
    3. Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer.
      Title: Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer.
    4. PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer.
      Title: PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer.
    5. PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway.
      Title: PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway.
    6. Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
      Title: Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
    7. LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/beta-catenin/cyclin D1 signaling via PLAGL2.
      Title: LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/β-catenin/cyclin D1 signaling via PLAGL2.
    8. PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/beta-catenin Pathway.
      Title: PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/β-catenin Pathway.
    9. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma.
      Title: Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma.
    10. MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
      Title: MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23283

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chylomicron assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein PLAGL2
    Names
    C2H2-type zinc finger protein
    pleiomorphic adenoma gene-like 2
    pleiomorphic adenoma-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002657.3 → NP_002648.1  zinc finger protein PLAGL2

      See identical proteins and their annotated locations for NP_002648.1

      Status: REVIEWED

      Source sequence(s)
      AL121897, BC023655
      Consensus CDS
      CCDS13197.1
      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8
      Related
      ENSP00000246229.4, ENST00000246229.5
      Conserved Domains (2) summary
      sd00017
      Location:70 → 92
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:85 → 109
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      32192504..32207743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440200.1 → XP_047296156.1  zinc finger protein PLAGL2 isoform X1

      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8

    2. XM_011528864.3 → XP_011527166.1  zinc finger protein PLAGL2 isoform X1

      See identical proteins and their annotated locations for XP_011527166.1

      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8
      Conserved Domains (2) summary
      sd00017
      Location:70 → 92
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:85 → 109
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005260436.4 → XP_005260493.1  zinc finger protein PLAGL2 isoform X1

      See identical proteins and their annotated locations for XP_005260493.1

      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8
      Conserved Domains (2) summary
      sd00017
      Location:70 → 92
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:85 → 109
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      33916427..33931666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323512.1 → XP_054179487.1  zinc finger protein PLAGL2 isoform X1

      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8

    2. XM_054323511.1 → XP_054179486.1  zinc finger protein PLAGL2 isoform X1

      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8

    3. XM_054323510.1 → XP_054179485.1  zinc finger protein PLAGL2 isoform X1

      UniProtKB/Swiss-Prot
      A8K8T5, E1P5M3, Q92584, Q9UPG8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPG8.1 GenPept UniProtKB/Swiss-Prot:Q9UPG8

    Gene LinkOut

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