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    MED26 mediator complex subunit 26 [ Homo sapiens (human) ]

    Gene ID: 9441, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MED26provided by HGNC
    Official Full Name
    mediator complex subunit 26provided by HGNC
    Primary source
    HGNC:HGNC:2376
    See related
    Ensembl:ENSG00000105085 MIM:605043; AllianceGenome:HGNC:2376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRSP7; CRSP70
    Summary
    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 18.2), bone marrow (RPKM 6.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MED26 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16574919..16628204, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16709708..16762995, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16685730..16739015, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10304 Neighboring gene RNA, 7SL, cytoplasmic 146, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14237 Neighboring gene solute carrier family 35 member E1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16680351-16680851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16683261-16684135 Neighboring gene uncharacterized LOC105372295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16692801-16693372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16693373-16693944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16695630-16696166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16696804-16697686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16702872-16703374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16716746-16717543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16739143-16740074 Neighboring gene uncharacterized LOC105372296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16748865-16749364 Neighboring gene small integral membrane protein 7 Neighboring gene uncharacterized LOC124904647

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70. Booth V, et al. J Biol Chem, 2000 Oct 6. PMID 10811649
    2. MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. Ding N, et al. J Biol Chem, 2009 Jan 30. PMID 19049968, Free PMC Article
    3. Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7. Lens Z, et al. J Mol Biol, 2017 Oct 13. PMID 28893534
    4. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Näär AM, et al. Genes Dev, 2002 Jun 1. PMID 12050112, Free PMC Article
    5. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. Takahashi H, et al. Nat Commun, 2015 Jan 9. PMID 25575120, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain.
      Title: Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.
    2. the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
      Title: MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.
    3. MED26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription.
      Title: Human mediator subunit MED26 functions as a docking site for transcription elongation factors.
    4. findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression
      Title: MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression.
    5. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
      Title: Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of mediator complex subunit 26 (MED26) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of MED26 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 26
    Names
    ARC70
    CRSP complex subunit 7
    activator-recruited cofactor 70 kDa component
    cofactor required for Sp1 transcriptional activation subunit 7
    cofactor required for Sp1 transcriptional activation, subunit 7 (70kD)
    cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa
    transcriptional coactivator CRSP70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004831.5 → NP_004822.2  mediator of RNA polymerase II transcription subunit 26

      See identical proteins and their annotated locations for NP_004822.2

      Status: VALIDATED

      Source sequence(s)
      AC008764, AC024075, AF104253, AK128435
      Consensus CDS
      CCDS12347.1
      UniProtKB/Swiss-Prot
      A1A4S3, O95402, Q0VGB6
      UniProtKB/TrEMBL
      B2R9G9
      Related
      ENSP00000263390.3, ENST00000263390.8
      Conserved Domains (3) summary
      smart00509
      Location:12 → 86
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:419 → 598
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:177 → 417
      Med26_M; Mediator complex subunit 26 middle domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      16574919..16628204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      16709708..16762995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95402.2 GenPept UniProtKB/Swiss-Prot:O95402

    Gene LinkOut

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