RAMAC RNA guanine-7 methyltransferase activating subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAMACprovided by HGNC
Official Full Name: RNA guanine-7 methyltransferase activating subunitprovided by HGNC
Primary source: HGNC:HGNC:31022
See related: Ensembl:ENSG00000169612 MIM:614547; AllianceGenome:HGNC:31022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAM; RAMMET; C15orf18; FAM103A1; HsT19360
Summary: Enables RNA binding activity and enzyme activator activity. Involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Located in nucleoplasm. Part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q25.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (82986210..82991057)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (80850581..80855428)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (83654962..83659809)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of allosteric activation of human RNMT by RAM has been reported.
Title: Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations.
RNMT-RAM complex coordinates mRNA processing with ribosome production.
Title: c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production.
Data suggest that RAM/FAM103A1 has three domains: N-terminal activation domain (RAD); central RNA-binding domain (NR domain); and C-terminal nuclear localization domain (QYP) which contains two nuclear localization signal sequences.
Title: RAM function is dependent on Kapβ2-mediated nuclear entry.
RAM is an essential component of the core gene expression machinery
Title: RAM/Fam103a1 is required for mRNA cap methylation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65049 (e-PCR)
- UniSTS:86795

STS-N36410 (e-PCR)
- UniSTS:42529

RH64882 (e-PCR)
- UniSTS:84961

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA 5'-cap (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of mRNA cap methyltransferase RNMT:RAMAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of mRNA capping enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mRNA capping enzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA guanine-N7 methyltransferase activating subunit

Names: RNMT activating mRNA cap methyltransferase subunit; RNMT-activating mini protein; family with sequence similarity 103 member A1; protein FAM103A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.