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    DAPK1 death associated protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 1612, updated on 2-May-2024

    Summary

    Official Symbol
    DAPK1provided by HGNC
    Official Full Name
    death associated protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:2674
    See related
    Ensembl:ENSG00000196730 MIM:600831; AllianceGenome:HGNC:2674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAPK; ROCO3
    Summary
    Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DAPK1 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87497228..87708634)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (99650695..99862240)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90112143..90323549)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376127 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:90001899-90002782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90017019-90017636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90017637-90018252 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:90020422-90020972 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene hESC enhancers GRCh37_chr9:90024569-90025224 and GRCh37_chr9:90025225-90025878 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90025879-90026532 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:90031115-90031768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20001 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:90113131-90113888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28520 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:90145230-90146212 Neighboring gene ribosomal protein S29 pseudogene 18 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108388 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108397 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90178705-90179204 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108408 Neighboring gene DAPK1 intronic transcript 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90186048-90186548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90207629-90208129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90215267-90215860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90234560-90235060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90249751-90250336 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:90308876-90309094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:90314444-90315643 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:90317453-90318652 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:90328302-90329501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28523 Neighboring gene CTSL promoter region Neighboring gene CTSL 3' regulatory element Neighboring gene EIF3J pseudogene 3 Neighboring gene cathepsin L

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
    EBI GWAS Catalog
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp781I035

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to tumor cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of NMDA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DAPK1-calmodulin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    death-associated protein kinase 1
    Names
    DAP kinase 1
    NP_001275658.1
    NP_001275659.1
    NP_001275660.1
    NP_004929.2
    XP_005251814.1
    XP_016869849.1
    XP_047278842.1
    XP_047278843.1
    XP_047278844.1
    XP_054218179.1
    XP_054218180.1
    XP_054218181.1
    XP_054218182.1
    XP_054218183.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029883.1 RefSeqGene

      Range
      5027..215794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288729.2NP_001275658.1  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001275658.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AA854055, AL160279, BC113660, BP202018, CD642694, CN347006, CX758421, DA234399, DA855348, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000484267.1, ENST00000622514.4
      Conserved Domains (5) summary
      PLN03192
      Location:515768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367639
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001288730.2NP_001275659.1  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001275659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AB208871, BC113660, BC143733, DC340223, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000417076.1, ENST00000472284.5
      Conserved Domains (5) summary
      PLN03192
      Location:515768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367639
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001288731.2NP_001275660.1  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001275660.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL160279, AL161787, AL591852, BC113660, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000350785.5, ENST00000358077.9
      Conserved Domains (5) summary
      PLN03192
      Location:515768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367639
      Ank_2; Ankyrin repeats (3 copies)
    4. NM_004938.4NP_004929.2  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_004929.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK295119, BC113660, BG110813, CX872304, DR002874, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000386135.3, ENST00000408954.8
      Conserved Domains (5) summary
      PLN03192
      Location:515768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367639
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      87497228..87708634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422887.1XP_047278843.1  death-associated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
    2. XM_047422886.1XP_047278842.1  death-associated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
    3. XM_005251757.5XP_005251814.1  death-associated protein kinase 1 isoform X3

      Conserved Domains (6) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:505629
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449541
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:347399
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
    4. XM_047422888.1XP_047278844.1  death-associated protein kinase 1 isoform X4

    5. XM_017014360.2XP_016869849.1  death-associated protein kinase 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      99650695..99862240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362205.1XP_054218180.1  death-associated protein kinase 1 isoform X1

    2. XM_054362204.1XP_054218179.1  death-associated protein kinase 1 isoform X1

    3. XM_054362207.1XP_054218182.1  death-associated protein kinase 1 isoform X3

    4. XM_054362208.1XP_054218183.1  death-associated protein kinase 1 isoform X4

    5. XM_054362206.1XP_054218181.1  death-associated protein kinase 1 isoform X2