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    OR1F1 olfactory receptor family 1 subfamily F member 1 [ Homo sapiens (human) ]

    Gene ID: 4992, updated on 3-Apr-2024

    Summary

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    Official Symbol
    OR1F1provided by HGNC
    Official Full Name
    olfactory receptor family 1 subfamily F member 1provided by HGNC
    Primary source
    HGNC:HGNC:8194
    See related
    Ensembl:ENSG00000168124 MIM:603232; AllianceGenome:HGNC:8194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OLFMF; OR1F4; OR1F5; OR1F6; OR1F7; OR1F8; OR1F9; OR1F10; OR16-36; OR16-37; OR16-88; OR16-89; OR16-90; OR1F13P; OR3-145; ORL1023
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3188204..3206556)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3214814..3233547)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3238204..3256506)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7127 Neighboring gene tRNA-Pro (anticodon TGG) 3-4 Neighboring gene tRNA-Pro (anticodon TGG) 3-5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7128 Neighboring gene tRNA-Pro (anticodon AGG) 2-8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7129 Neighboring gene tRNA-Lys (anticodon CTT) 4-1 Neighboring gene tRNA-Pro (anticodon AGG) 1-1 Neighboring gene tRNA-Lys (anticodon CTT) 14-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3261768-3261996 Neighboring gene olfactory receptor family 1 subfamily F member 2 pseudogene Neighboring gene zinc finger protein 200

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A candidate gene for familial Mediterranean fever. French FMF Consortium. Nat Genet, 1997 Sep. PMID 9288094
    2. A transcriptional Map of the FMF region. Bernot A, et al. Genomics, 1998 Jun 1. PMID 9653642
    3. Distribution of olfactory receptor genes in the human genome. Rouquier S, et al. Nat Genet, 1998 Mar. PMID 9500546
    4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • AJ003147.9

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 1F1
    Names
    olfactory receptor, family 1, subfamily F, member 10
    olfactory receptor, family 1, subfamily F, member 13 pseudogene
    olfactory receptor, family 1, subfamily F, member 4
    olfactory receptor, family 1, subfamily F, member 5
    olfactory receptor, family 1, subfamily F, member 6
    olfactory receptor, family 1, subfamily F, member 7
    olfactory receptor, family 1, subfamily F, member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370639.4 → NP_001357568.2  olfactory receptor 1F1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AJ003147
      UniProtKB/Swiss-Prot
      O15246, O43749, Q6IFL5

    2. NM_001370640.6 → NP_001357569.2  olfactory receptor 1F1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AJ003147
      UniProtKB/Swiss-Prot
      O15246, O43749, Q6IFL5
      Related
      ENSP00000305424.2, ENST00000304646.3

    3. NM_001370641.2 → NP_001357570.1  olfactory receptor 1F1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AJ003147
      Consensus CDS
      CCDS10496.1
      UniProtKB/Swiss-Prot
      O15246, O43749, Q6IFL5
      UniProtKB/TrEMBL
      A0A126GVR9
      Conserved Domains (1) summary
      cd15918
      Location:25 → 294
      7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_012360.3 → NP_036492.1  olfactory receptor 1F1 isoform 1

      See identical proteins and their annotated locations for NP_036492.1

      Status: VALIDATED

      Source sequence(s)
      AJ003147
      Consensus CDS
      CCDS10496.1
      UniProtKB/Swiss-Prot
      O15246, O43749, Q6IFL5
      UniProtKB/TrEMBL
      A0A126GVR9
      Conserved Domains (1) summary
      cd15918
      Location:25 → 294
      7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3188204..3206556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522507.4 → XP_011520809.1  olfactory receptor 1F1 isoform X1

      See identical proteins and their annotated locations for XP_011520809.1

      UniProtKB/Swiss-Prot
      O15246, O43749, Q6IFL5
      UniProtKB/TrEMBL
      A0A126GVR9
      Conserved Domains (1) summary
      cd15918
      Location:25 → 294
      7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3214814..3233547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380407.1 → XP_054236382.1  olfactory receptor 1F1 isoform X1

      UniProtKB/Swiss-Prot
      O15246, O43749, Q6IFL5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43749.1 GenPept UniProtKB/Swiss-Prot:O43749

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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