KLF17 KLF transcription factor 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF17provided by HGNC
Official Full Name: KLF transcription factor 17provided by HGNC
Primary source: HGNC:HGNC:18830
See related: Ensembl:ENSG00000171872 MIM:609602; AllianceGenome:HGNC:18830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZLF393; ZNF393; Zfp393
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within gamete generation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 3.2), endometrium (RPKM 0.4) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (44043927..44135140)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (43915021..44006090)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (44584493..44600812)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
Title: KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
KLF17 promotes human naive pluripotency but is not required for its establishment.
Title: KLF17 promotes human naïve pluripotency but is not required for its establishment.
Up-regulation of KLF17 expression increases the sensitivity of gastric cancer to 5-fluorouracil.
Title: Up-regulation of KLF17 expression increases the sensitivity of gastric cancer to 5-fluorouracil.
Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.
Title: Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.
Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17.
Title: Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17.
Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study.
Title: Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study.
Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
Title: Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
The above data show that normal levels of melatonin may help in preventing breast cancer metastasis through inhibiting DJ-1/KLF17/ID-1 signaling pathway. The combination of melatonin and taxol is a potent candidate against breast cancer metastasis, better than using melatonin or taxol as a single drug
Title: Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway.
Results revealed that KLF17 expression was abnormally decreased in colorectal cancer (CRC) and associated with lymph node metastasis and unfavorable overall survival. Moreover, ectopic KLF17 expression suppressed CRC cell growth and invasion in vitro and in vivo. In addition, the downregulation of KLF17 was associated with the hypermethylation of the CpG nucleotides on the KLF17 promoter.
Title: Clinical significance and biological role of KLF17 as a tumour suppressor in colorectal cancer.
Low Expressions of KLF17 is associated with lung adenocarcinoma.
Title: Krüppel-like factor 17 inhibits urokinase plasminogen activator gene expression to suppress cell invasion through the Src/p38/ MAPK signaling pathway in human lung adenocarcionma.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G43535 (e-PCR)
- UniSTS:94992

RH124565 (e-PCR)
- UniSTS:161387

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 17

Names: Kruppel like factor 17; novel zinc-finger protein; zinc finger protein 393

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173484.4 → NP_775755.3 Krueppel-like factor 17

See identical proteins and their annotated locations for NP_775755.3

Status: VALIDATED

Source sequence(s)

AL356653, BC049844, DB046781

Consensus CDS

CCDS508.1

UniProtKB/Swiss-Prot

Q5JT82, Q86VQ7, Q8N805

Related

ENSP00000361373.3, ENST00000372299.4

Conserved Domains (4) summary

COG5048
Location:282 → 350

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:285 → 307

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:343 → 365

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:329 → 352

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

44043927..44135140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011540700.2 → XP_011539002.1 Krueppel-like factor 17 isoform X1

See identical proteins and their annotated locations for XP_011539002.1

Conserved Domains (4) summary

COG5048
Location:245 → 313

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:248 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:306 → 328

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:292 → 315

zf-H2C2_2; Zinc-finger double domain
XM_047445936.1 → XP_047301892.1 Krueppel-like factor 17 isoform X1
XM_047445938.1 → XP_047301894.1 Krueppel-like factor 17 isoform X1
XM_005270465.4 → XP_005270522.2 Krueppel-like factor 17 isoform X2

Conserved Domains (4) summary

COG5048
Location:108 → 211

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:175 → 197

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:233 → 255

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:219 → 242

zf-H2C2_2; Zinc-finger double domain
XM_011540704.3 → XP_011539006.1 Krueppel-like factor 17 isoform X3

Conserved Domains (4) summary

COG5048
Location:145 → 232

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:156 → 178

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:214 → 236

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:200 → 223

zf-H2C2_2; Zinc-finger double domain