U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HS3ST4 heparan sulfate-glucosamine 3-sulfotransferase 4 [ Homo sapiens (human) ]

Gene ID: 9951, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
HS3ST4provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 4provided by HGNC
Primary source
HGNC:HGNC:5200
See related
Ensembl:ENSG00000182601 MIM:604059; AllianceGenome:HGNC:5200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
30ST4; 3OST4; 3-OST-4; h3-OST-4
Summary
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.8), spleen (RPKM 1.0) and 1 other tissue See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16p12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (25691959..26137685)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (25968488..26414068)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (25703280..26149006)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371147 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:25564716-25565915 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:25580065-25581264 Neighboring gene NANOG hESC enhancer GRCh37_chr16:25586609-25587370 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:25644366-25645565 Neighboring gene uncharacterized LOC105369297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:25704024-25704524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:25704525-25705025 Neighboring gene TNF receptor associated factor 7 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:25855925-25856182 Neighboring gene Sharpr-MPRA regulatory region 8309 Neighboring gene NANOG hESC enhancer GRCh37_chr16:25896223-25896797 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:25899968-25901167 Neighboring gene NANOG hESC enhancer GRCh37_chr16:25959776-25960299 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:25961820-25962673 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:25962674-25963526 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:26055617-26055798 Neighboring gene RNA, 5S ribosomal pseudogene 405 Neighboring gene microRNA 548w Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 3 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:26137874-26139073 Neighboring gene NANOG hESC enhancer GRCh37_chr16:26144955-26145467 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:26188562-26189392 Neighboring gene uncharacterized LOC105371149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:26290511-26291012 Neighboring gene uncharacterized LOC105371150

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus-mediated fusogenic activity. Ohka S, et al. Mol Pain, 2021 Jan-Dec. PMID 34904858, Free PMC Article
  2. A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread. Tiwari V, et al. Biochem Biophys Res Commun, 2005 Dec 16. PMID 16259945
  3. Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. Liu J, et al. J Biol Chem, 2002 Sep 6. PMID 12080045
  4. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Debette S, et al. Biol Psychiatry, 2015 Apr 15. PMID 25648963, Free PMC Article
  5. Tetrasulfated disaccharide unit in heparan sulfate: enzymatic formation and tissue distribution. Mochizuki H, et al. J Biol Chem, 2008 Nov 7. PMID 18757372, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus-mediated fusogenic activity.
    Title: Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus-mediated fusogenic activity.
  2. This study provided that additional genome-wide associations, near HS3ST4 were identified and other putative modulators of memory performance were revealed by a pathway approach and hippocampal gene expression analyses.
    Title: Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. The 3OST-2 and -4 are specifically expressed in brain.
    Title: Tetrasulfated disaccharide unit in heparan sulfate: enzymatic formation and tissue distribution.
  5. 3-OST-2 and 3-OST-4 are the major neural gD-type 3-OSTs, and so are prime candidates for participating in HS-dependent neurobiologic events.
    Title: The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heparan sulfate proteoglycan metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 4
Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
heparan sulfate 3-O-sulfotransferase 4
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4
NP_006031.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006040.3 → NP_006031.2  heparan sulfate glucosamine 3-O-sulfotransferase 4

    See identical proteins and their annotated locations for NP_006031.2

    Status: REVIEWED

    Source sequence(s)
    AC092141, AC093511, AF105378
    Consensus CDS
    CCDS53995.1
    UniProtKB/Swiss-Prot
    Q5QI42, Q8NDC2, Q9Y661
    Related
    ENSP00000330606.5, ENST00000331351.6
    Conserved Domains (1) summary
    pfam00685
    Location:197 → 434
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    25691959..26137685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    25968488..26414068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y661.3 GenPept UniProtKB/Swiss-Prot:Q9Y661

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous