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GOLGA5 golgin A5 [ Homo sapiens (human) ]

Gene ID: 9950, updated on 7-Apr-2024

Summary

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Official Symbol
GOLGA5provided by HGNC
Official Full Name
golgin A5provided by HGNC
Primary source
HGNC:HGNC:4428
See related
Ensembl:ENSG00000066455 MIM:606918; AllianceGenome:HGNC:4428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFG5; GOLIM5; ret-II
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 23.6), thyroid (RPKM 21.8) and 25 other tissues See more
Orthologs
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Genomic context

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See GOLGA5 in Genome Data Viewer
Location:
14q32.12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (92794305..92839947)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (87026063..87071707)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93260650..93306292)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 3 Neighboring gene uncharacterized LOC124903364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93152626-93153253 Neighboring gene Sharpr-MPRA regulatory region 13986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6038 Neighboring gene Sharpr-MPRA regulatory region 11533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93175352-93175977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93175978-93176602 Neighboring gene legumain Neighboring gene Sharpr-MPRA regulatory region 3328 Neighboring gene MPRA-validated peak2238 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6039 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:93260331-93260478 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93260501-93261045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93261046-93261589 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:93312588-93313787 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:93369186-93370385 Neighboring gene long intergenic non-protein coding RNA 2833 Neighboring gene long intergenic non-protein coding RNA 2287

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting of a chlamydial protease impedes intracellular bacterial growth. Christian JG, et al. PLoS Pathog, 2011 Sep. PMID 21990969, Free PMC Article
  2. Interaction of Golgin-84 with the COG complex mediates the intra-Golgi retrograde transport. Sohda M, et al. Traffic, 2010 Dec. PMID 20874812
  3. Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction. Heuer D, et al. Nature, 2009 Feb 5. PMID 19060882
  4. Membrane traffic: a glitch in the Golgi matrix. Short B, et al. Curr Biol, 2003 Apr 15. PMID 12699642
  5. Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5. Klugbauer S, et al. Cancer Res, 1998 Jan 15. PMID 9443391

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golgin-84 on coat protein I vesicles interacts with the conserved oligomeric Golgi complex before SNARE assembly.
    Title: Interaction of Golgin-84 with the COG complex mediates the intra-Golgi retrograde transport.
  2. involved in generating and maintaining the architecture of the Golgi apparatus
    Title: Golgin-84 is a rab1 binding partner involved in Golgi structure.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, vesicle recycling within Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in transport vesicle TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
golgin subfamily A member 5
Names
RET-fused gene 5 protein
cell proliferation-inducing gene 31 protein
golgi autoantigen, golgin subfamily a, 5
golgi integral membrane protein 5
golgin-84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023248.3 RefSeqGene

    Range
    5002..50644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005113.4 → NP_005104.4  golgin subfamily A member 5

    Status: REVIEWED

    Source sequence(s)
    AL132987
    Consensus CDS
    CCDS9905.1
    UniProtKB/Swiss-Prot
    C9JRU1, O95287, Q03962, Q2TS49, Q8TBA6, Q9UQQ7
    UniProtKB/TrEMBL
    A8KAL2
    Related
    ENSP00000163416.2, ENST00000163416.7
    Conserved Domains (2) summary
    pfam09787
    Location:420 → 725
    Golgin_A5; Golgin subfamily A member 5
    cl25732
    Location:219 → 570
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    92794305..92839947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432021.1 → XP_047287977.1  golgin subfamily A member 5 isoform X1

    UniProtKB/Swiss-Prot
    C9JRU1, O95287, Q03962, Q2TS49, Q8TBA6, Q9UQQ7

  2. XM_011537420.4 → XP_011535722.1  golgin subfamily A member 5 isoform X2

    UniProtKB/TrEMBL
    A8KAL2
    Conserved Domains (2) summary
    pfam09787
    Location:235 → 683
    Golgin_A5; Golgin subfamily A member 5
    cl23720
    Location:479 → 575
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    87026063..87071707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377147.1 → XP_054233122.1  golgin subfamily A member 5 isoform X2

  2. XM_054377146.1 → XP_054233121.1  golgin subfamily A member 5 isoform X1

    UniProtKB/Swiss-Prot
    C9JRU1, O95287, Q03962, Q2TS49, Q8TBA6, Q9UQQ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TBA6.3 GenPept UniProtKB/Swiss-Prot:Q8TBA6

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