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CDC25A cell division cycle 25A [ Homo sapiens (human) ]

Gene ID: 993, updated on 11-Apr-2024

Summary

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Official Symbol
CDC25Aprovided by HGNC
Official Full Name
cell division cycle 25Aprovided by HGNC
Primary source
HGNC:HGNC:1725
See related
Ensembl:ENSG00000164045 MIM:116947; AllianceGenome:HGNC:1725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC25A2
Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues See more
Orthologs
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Genomic context

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See CDC25A in Genome Data Viewer
Location:
3p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48157146..48188417, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48184306..48215830, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48198636..48229907, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene MPRA-validated peak4638 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48154883-48155384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48155385-48155884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48157513-48158444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48160097-48160597 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:48164888-48165071 Neighboring gene ribosomal protein L17 pseudogene 16 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:48189821-48190010 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 4 Neighboring gene RNA, U7 small nuclear 128 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48228992-48229620 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48237715-48238244 Neighboring gene microRNA 4443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19825 Neighboring gene Sharpr-MPRA regulatory region 12857 Neighboring gene cathelicidin antimicrobial peptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition. Ditano JP, et al. Cell Cycle, 2021 Jul. PMID 34156324, Free PMC Article
  2. CDC25A pathway toward tumorigenesis: Molecular targets of CDC25A in cell-cycle regulation. Sadeghi H, et al. J Cell Biochem, 2019 Mar. PMID 30443958
  3. Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth. Al-Matouq J, et al. Cancer Lett, 2017 Dec 1. PMID 28951130
  4. Cdc25A phosphatase: a key cell cycle protein that regulates neuron death in disease and development. Biswas SC, et al. Cell Death Dis, 2017 Mar 23. PMID 28333146, Free PMC Article
  5. CyclinD-CDK4/6 complexes phosphorylate CDC25A and regulate its stability. Dozier C, et al. Oncogene, 2017 Jun 29. PMID 28192398

See all (220) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis.
    Title: Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis.
  2. Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.
    Title: Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.
  3. Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
    Title: Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.
  4. miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
    Title: miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
  5. Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
    Title: Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
  6. FBXW8 regulates G1 and S phases of cell cycle progression by restricting beta-TrCP1 function.
    Title: FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function.
  7. Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
    Title: Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
  8. LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A.
    Title: LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A.
  9. TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
    Title: TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
  10. HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.
    Title: HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.
Submit: New GeneRIF Correction See all GeneRIFs (124)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed
Vpu vpu HIV-1 Vpu stabilizes cellular Cdc25A and differentially affects betaTrCP-mediated degradation events at different phases of the cell cycle PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
  
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA replication TAS
Traceable Author Statement
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to radiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
M-phase inducer phosphatase 1
Names
CDC25 homolog A
dual specificity phosphatase CDC25A
NP_001780.2
NP_963861.1
XP_047305319.1
XP_047305320.1
XP_047305321.1
XP_047305322.1
XP_047305323.1
XP_054204613.1
XP_054204614.1
XP_054204615.1
XP_054204616.1
XP_054204617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001789.3 → NP_001780.2  M-phase inducer phosphatase 1 isoform a

    See identical proteins and their annotated locations for NP_001780.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC104190, AC124916, AI917350, BC007401, BQ065803, BX392016
    Consensus CDS
    CCDS2760.1
    UniProtKB/Swiss-Prot
    P30304, Q8IZH5, Q96IL3, Q9H2F2
    UniProtKB/TrEMBL
    A8K3D9
    Related
    ENSP00000303706.3, ENST00000302506.8
    Conserved Domains (2) summary
    cd01530
    Location:357 → 475
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86 → 328
    M-inducer_phosp; M-phase inducer phosphatase

  2. NM_201567.2 → NP_963861.1  M-phase inducer phosphatase 1 isoform b

    See identical proteins and their annotated locations for NP_963861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC104190, AC124916, AI917350, AY137580, BC007401, BQ065803, BX392016
    Consensus CDS
    CCDS2761.1
    UniProtKB/TrEMBL
    A8K3D9
    Related
    ENSP00000343166.3, ENST00000351231.7
    Conserved Domains (2) summary
    cd01530
    Location:317 → 435
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86 → 288
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    48157146..48188417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449366.1 → XP_047305322.1  M-phase inducer phosphatase 1 isoform X4

    UniProtKB/TrEMBL
    D8KXX0

  2. XM_047449364.1 → XP_047305320.1  M-phase inducer phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    K7N7S0

  3. XM_047449365.1 → XP_047305321.1  M-phase inducer phosphatase 1 isoform X3

  4. XM_047449363.1 → XP_047305319.1  M-phase inducer phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    P30304, Q8IZH5, Q96IL3, Q9H2F2

  5. XM_047449367.1 → XP_047305323.1  M-phase inducer phosphatase 1 isoform X5

    Related
    ENSP00000416483.1, ENST00000443342.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    48184306..48215830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348641.1 → XP_054204616.1  M-phase inducer phosphatase 1 isoform X4

    UniProtKB/TrEMBL
    D8KXX0

  2. XM_054348639.1 → XP_054204614.1  M-phase inducer phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    K7N7S0

  3. XM_054348640.1 → XP_054204615.1  M-phase inducer phosphatase 1 isoform X3

  4. XM_054348638.1 → XP_054204613.1  M-phase inducer phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    P30304, Q8IZH5, Q96IL3, Q9H2F2

  5. XM_054348642.1 → XP_054204617.1  M-phase inducer phosphatase 1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30304.2 GenPept UniProtKB/Swiss-Prot:P30304

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