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SLK STE20 like kinase [ Homo sapiens (human) ]

Gene ID: 9748, updated on 5-Mar-2024

Summary

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Official Symbol
SLKprovided by HGNC
Official Full Name
STE20 like kinaseprovided by HGNC
Primary source
HGNC:HGNC:11088
See related
Ensembl:ENSG00000065613 MIM:616563; AllianceGenome:HGNC:11088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOSK; STK2; se20-9; bA16H23.1
Summary
Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.33-q25.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103967140..104029233)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104854380..104916616)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105726898..105788991)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene STN1 subunit of CST complex Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105667461-105668062 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 10:105668179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105677593-105678238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105686883-105687548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105688215-105688880 Neighboring gene uncharacterized LOC102724351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105730769-105731270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105731271-105731770 Neighboring gene RNA, 7SL, cytoplasmic 524, pseudogene Neighboring gene collagen type XVII alpha 1 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105812840-105813426 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:105813739-105814938 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105826696-105827351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105827352-105828006 Neighboring gene microRNA 936 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:105879992-105881191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105881347-105882010 Neighboring gene SWI5 dependent homologous recombination repair protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction. Wang Y, et al. Am J Respir Cell Mol Biol, 2020 May. PMID 31913659, Free PMC Article
  2. Ste20-like kinase is upregulated in glioma and induces glioma invasion. Wang K, et al. Neoplasma, 2018. PMID 29534578
  3. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. Yamada E, et al. Biochim Biophys Acta, 2000 Feb 28. PMID 10699464
  4. SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. Fokin AI, et al. Cytoskeleton (Hoboken), 2016 Feb. PMID 26818812
  5. SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation. Machicoane M, et al. J Cell Biol, 2014 Jun 23. PMID 24958772, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLK-mediated actin cytoskeletal reorganization may facilitate force transmission between the contractile units and the extracellular matrix.
    Title: Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.
  2. The inhibition of SLK by RNA interference significantly suppressed the invasion ability of glioma, and on protein level, knock- down of SLK leaded to an up-regulation of E-cadherin and a down-regulation of Vimentin in glioma cells.
    Title: Ste20-like kinase is upregulated in glioma and induces glioma invasion.
  3. SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK.
    Title: Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.
  4. SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation.
    Title: SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation.
  5. The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms
    Title: Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.
  6. It was shown that lymphocyte-oriented and STE20 kinase were sufficient to restrict ezrin function to the apical domain. Both kinases were enriched in microvilli and locally activated there.
    Title: Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  8. Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility.
    Title: The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.
  9. Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types.
    Title: Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase.
  10. we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade
    Title: Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0204, MGC133067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
STE20-like serine/threonine-protein kinase
Names
CTCL tumor antigen se20-9
Long Ste20-like Kinase
SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase
SNF1 sucrose nonfermenting like kinase
STE20-related kinase
STE20-related serine/threonine-protein kinase
Ste20-related serine/threonine kinase
hSLK
serine/threonine-protein kinase 2
NP_001291672.1
NP_055535.2
XP_011538703.1
XP_047281995.1
XP_054223219.1
XP_054223220.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304743.2 → NP_001291672.1  STE20-like serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001291672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AL138761, AL360170, BC008697, BC047885, BC111565
    Consensus CDS
    CCDS76334.1
    UniProtKB/TrEMBL
    B4DZC9
    Related
    ENSP00000336824.4, ENST00000335753.8
    Conserved Domains (3) summary
    smart00220
    Location:34 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28 → 309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:989 → 1129
    PKK; Polo kinase kinase

  2. NM_014720.4 → NP_055535.2  STE20-like serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_055535.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF273048, AL138761, AL360170, BC047885
    Consensus CDS
    CCDS7553.1
    UniProtKB/Swiss-Prot
    D3DRA0, D3DRA1, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9H2G2, Q9NQL0, Q9NQL1
    UniProtKB/TrEMBL
    B4DZC9
    Related
    ENSP00000358770.3, ENST00000369755.4
    Conserved Domains (3) summary
    smart00220
    Location:34 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28 → 309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:1020 → 1160
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    103967140..104029233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540401.4 → XP_011538703.1  STE20-like serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:34 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28 → 309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:568 → 708
    PKK; Polo kinase kinase

  2. XM_047426039.1 → XP_047281995.1  STE20-like serine/threonine-protein kinase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    104854380..104916616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367244.1 → XP_054223219.1  STE20-like serine/threonine-protein kinase isoform X1

  2. XM_054367245.1 → XP_054223220.1  STE20-like serine/threonine-protein kinase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2G2.1 GenPept UniProtKB/Swiss-Prot:Q9H2G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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