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ARHGAP32 Rho GTPase activating protein 32 [ Homo sapiens (human) ]

Gene ID: 9743, updated on 7-Apr-2024

Summary

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Official Symbol
ARHGAP32provided by HGNC
Official Full Name
Rho GTPase activating protein 32provided by HGNC
Primary source
HGNC:HGNC:17399
See related
Ensembl:ENSG00000134909 MIM:608541; AllianceGenome:HGNC:17399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
Summary
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
11q24.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (128965060..129279632, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (128999975..129315124, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128834955..129149413, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:128771525-128772283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4065 Neighboring gene KCNJ5 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:128796283-128797283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5746 Neighboring gene potassium inwardly rectifying channel subfamily J member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128808070-128808570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128808571-128809071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128810609-128811109 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128840383-128840884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128840885-128841384 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:128868598-128869797 Neighboring gene RNA, U6 small nuclear 876, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:128931012-128932211 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:129012637-129013836 Neighboring gene RNA, U6 small nuclear 874, pseudogene Neighboring gene uncharacterized LOC399975 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:129122522-129123022 Neighboring gene HNF4 motif-containing MPRA enhancer 230 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129152926-129153427 Neighboring gene uncharacterized LOC124902791 Neighboring gene zinc finger protein 123, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits. Ohi K, et al. PLoS One, 2012. PMID 22530067, Free PMC Article
  2. Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Gardiner EM, et al. Curr Biol, 2002 Dec 10. PMID 12477392
  3. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Wayman GA, et al. Proc Natl Acad Sci U S A, 2008 Jul 1. PMID 18577589, Free PMC Article
  4. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Taniguchi S, et al. Biochem Biophys Res Commun, 2003 Jun 20. PMID 12788081
  5. Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration. Wang Y, et al. Clin Hemorheol Microcirc, 2022. PMID 35662113

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study.
    Title: Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study.
  2. Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
    Title: Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
  3. Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain
    Title: p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation.
  4. the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia.
    Title: The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.
  5. The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
    Title: The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
  6. Results suggest that a splice variant of RICS, PX-RICS, is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits.
    Title: PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.
  7. miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity.
    Title: An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
  8. Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling.
    Title: PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.
  9. These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases.
    Title: Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
  10. is phosphorylated by Fyn in oligodendrocytes
    Title: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1892, KIAA0712

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 32
Names
GAB-associated CDC42
GAB-associated Cdc42/Rac GTPase-activating protein
GTPase regulator interacting with TrkA
GTPase-activating protein for Cdc42 and Rac1
RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
brain-specific Rho GTP-ase-activating protein
brain-specific Rho GTPase-activating protein
rac GTPase activating protein
rho-type GTPase-activating protein 32
rho/Cdc42/Rac GTPase-activating protein RICS
rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142685.2 → NP_001136157.1  rho GTPase-activating protein 32 isoform 1

    See identical proteins and their annotated locations for NP_001136157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). This isoform is also known as PX-RICS.
    Source sequence(s)
    AP000747, AP000751, AP002886
    Consensus CDS
    CCDS44769.1
    UniProtKB/Swiss-Prot
    A7KAX9, I7H0B0, O94820, Q86YL6, Q8IUG4, Q9BWG3
    UniProtKB/TrEMBL
    A0A2X0SFD0
    Related
    ENSP00000310561.8, ENST00000310343.13
    Conserved Domains (3) summary
    cd07298
    Location:127 → 241
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:263 → 316
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:368 → 562
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

  2. NM_001378024.1 → NP_001364953.1  rho GTPase-activating protein 32 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AP000747, AP000751, AP002886
    Consensus CDS
    CCDS91623.1
    UniProtKB/TrEMBL
    A0A2X0SFD0, A0A804HK06
    Related
    ENSP00000507720.1, ENST00000682385.1
    Conserved Domains (3) summary
    cd07298
    Location:141 → 255
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:277 → 330
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:382 → 576
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

  3. NM_001378025.1 → NP_001364954.1  rho GTPase-activating protein 32 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP000747, AP000751, AP002886
    UniProtKB/TrEMBL
    A0A2X0SFD0
    Conserved Domains (3) summary
    cd07298
    Location:87 → 201
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:223 → 276
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:328 → 522
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

  4. NM_014715.4 → NP_055530.2  rho GTPase-activating protein 32 isoform 2

    See identical proteins and their annotated locations for NP_055530.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.
    Source sequence(s)
    AB079856, AP000751, BQ319051, EF127492
    Consensus CDS
    CCDS31718.1
    UniProtKB/TrEMBL
    A0A2X0SFD0
    Related
    ENSP00000376425.3, ENST00000392657.7
    Conserved Domains (1) summary
    cd04384
    Location:19 → 213
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    128965060..129279632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427929.1 → XP_047283885.1  rho GTPase-activating protein 32 isoform X4

  2. XM_047427927.1 → XP_047283883.1  rho GTPase-activating protein 32 isoform X2

  3. XM_047427926.1 → XP_047283882.1  rho GTPase-activating protein 32 isoform X2

  4. XM_047427930.1 → XP_047283886.1  rho GTPase-activating protein 32 isoform X4

  5. XM_017018595.3 → XP_016874084.1  rho GTPase-activating protein 32 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SFD0
    Conserved Domains (3) summary
    cd07298
    Location:101 → 215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237 → 290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342 → 536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

  6. XM_011543072.3 → XP_011541374.1  rho GTPase-activating protein 32 isoform X2

    See identical proteins and their annotated locations for XP_011541374.1

    UniProtKB/TrEMBL
    A0A2X0SFD0
    Conserved Domains (3) summary
    cd07298
    Location:101 → 215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237 → 290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342 → 536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

  7. XM_047427928.1 → XP_047283884.1  rho GTPase-activating protein 32 isoform X3

  8. XM_011543073.3 → XP_011541375.2  rho GTPase-activating protein 32 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SFD0

  9. XM_017018596.2 → XP_016874085.1  rho GTPase-activating protein 32 isoform X7

    UniProtKB/TrEMBL
    A0A2X0SFD0

  10. XM_011543075.3 → XP_011541377.1  rho GTPase-activating protein 32 isoform X5

    UniProtKB/TrEMBL
    A0A2X0SFD0
    Conserved Domains (1) summary
    cd04384
    Location:43 → 237
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

  11. XM_017018597.3 → XP_016874086.1  rho GTPase-activating protein 32 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    128999975..129315124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370623.1 → XP_054226598.1  rho GTPase-activating protein 32 isoform X2

  2. XM_054370625.1 → XP_054226600.1  rho GTPase-activating protein 32 isoform X4

  3. XM_054370620.1 → XP_054226595.1  rho GTPase-activating protein 32 isoform X2

  4. XM_054370626.1 → XP_054226601.1  rho GTPase-activating protein 32 isoform X4

  5. XM_054370621.1 → XP_054226596.1  rho GTPase-activating protein 32 isoform X2

  6. XM_054370622.1 → XP_054226597.1  rho GTPase-activating protein 32 isoform X2

  7. XM_054370624.1 → XP_054226599.1  rho GTPase-activating protein 32 isoform X3

  8. XM_054370619.1 → XP_054226594.1  rho GTPase-activating protein 32 isoform X1

  9. XM_054370627.1 → XP_054226602.1  rho GTPase-activating protein 32 isoform X5

  10. XM_054370628.1 → XP_054226603.1  rho GTPase-activating protein 32 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7KAX9.1 GenPept UniProtKB/Swiss-Prot:A7KAX9

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