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HDAC9 histone deacetylase 9 [ Homo sapiens (human) ]

Gene ID: 9734, updated on 8-Apr-2024

Summary

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Official Symbol
HDAC9provided by HGNC
Official Full Name
histone deacetylase 9provided by HGNC
Primary source
HGNC:HGNC:14065
See related
Ensembl:ENSG00000048052 MIM:606543; AllianceGenome:HGNC:14065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; ARCND4; HDAC7B; HDAC9B; HDAC9FL
Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 2.1), brain (RPKM 2.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See HDAC9 in Genome Data Viewer
Location:
7p21.1
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (18086825..19002416)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (18216502..19132425)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (18126448..19042039)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:18017138-18017327 Neighboring gene MRM3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:18126389-18126937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:18126938-18127485 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 like 1 Neighboring gene MPRA-validated peak6414 silencer Neighboring gene MPRA-validated peak6415 silencer Neighboring gene GATA motif-containing MPRA enhancer 275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25677 Neighboring gene microRNA 1302-6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25679 Neighboring gene uncharacterized LOC124900248 Neighboring gene Sharpr-MPRA regulatory region 1729 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:18436382-18437097 Neighboring gene NANOG hESC enhancer GRCh37_chr7:18447067-18447568 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:18459909-18461108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25680 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:18548259-18549458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17987 Neighboring gene NANOG hESC enhancer GRCh37_chr7:18590148-18590649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:18613316-18613854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:18613855-18614393 Neighboring gene casein kinase 1 alpha 1 pseudogene Neighboring gene uncharacterized LOC124901598 Neighboring gene eExon 18 TWIST1 limb enhancer Neighboring gene eExon 19 TWIST1 limb enhancer Neighboring gene VISTA enhancer hs644 Neighboring gene RN7SK pseudogene 266 Neighboring gene HDAC9 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:19029605-19030106 Neighboring gene nucleophosmin 1 pseudogene 13 Neighboring gene uncharacterized LOC124901597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:19156549-19157332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:19158406-19159269 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:19183777-19184976 Neighboring gene twist family bHLH transcription factor 1 Neighboring gene Fer3 like bHLH transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Histone Deacetylase9 Represents the Epigenetic Promotion of M1 Macrophage Polarization and Inflammatory Response via TLR4 Regulation. Cao X, et al. Biomed Res Int, 2022. PMID 35941971, Free PMC Article
  2. Downregulation of HDAC9 by the ketone metabolite β-hydroxybutyrate suppresses vascular calcification. Lan Z, et al. J Pathol, 2022 Nov. PMID 35894849
  3. Knockdown of HDAC9 Inhibits Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Partially by Suppressing the MAPK Signaling Pathway. Wang B, et al. Clin Interv Aging, 2022. PMID 35592642, Free PMC Article
  4. An HDAC9-associated immune-related signature predicts bladder cancer prognosis. Fu Y, et al. PLoS One, 2022. PMID 35239708, Free PMC Article
  5. HDAC9 in the Injury of Vascular Endothelial Cell Mediated by P38 MAPK Pathway. Kuang X, et al. J Interferon Cytokine Res, 2021 Dec. PMID 34935488

See all (177) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.
    Title: CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.
  2. Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
    Title: Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
  3. Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.
    Title: Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.
  4. Endothelial beta-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.
    Title: Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.
  5. HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.
    Title: HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.
  6. HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD.
    Title: HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD.
  7. Aberrant expression and regulatory role of histone deacetylase 9 in vascular endothelial cell injury in intracranial aneurysm.
    Title: Aberrant expression and regulatory role of histone deacetylase 9 in vascular endothelial cell injury in intracranial aneurysm.
  8. Role of histone deacetylase 9 in human periodontal ligament stem cells autophagy in a tumour necrosis factor alpha-induced inflammatory environment.
    Title: Role of histone deacetylase 9 in human periodontal ligament stem cells autophagy in a tumour necrosis factor α-induced inflammatory environment.
  9. Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease.
    Title: Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease.
  10. Sex-Dependent Role of Adipose Tissue HDAC9 in Diet-Induced Obesity and Metabolic Dysfunction.
    Title: Sex-Dependent Role of Adipose Tissue HDAC9 in Diet-Induced Obesity and Metabolic Dysfunction.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Auriculocondylar syndrome 4
MedGen: C5830659 OMIM: 620457 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genetic predictors of medically refractory ulcerative colitis.
EBI GWAS Catalog
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
EBI GWAS Catalog
Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.
EBI GWAS Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog
Genome-wide association study of retinopathy in individuals without diabetes.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0744, DKFZp779K1053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone H3K14 deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone H3K9 deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone H4K16 deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B cell activation TAS
Traceable Author Statement
more info
 PubMed 
involved_in B cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of striated muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
 PubMed 
part_of histone methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 9
Names
MEF-2 interacting transcription repressor (MITR) protein
histone deacetylase 4/5-related protein
histone deacetylase 7B
NP_001191073.1
NP_001191074.1
NP_001191075.1
NP_001191076.1
NP_001191077.1
NP_001308797.1
NP_001308798.1
NP_001308799.1
NP_001308800.1
NP_001308801.1
NP_001308802.1
NP_001308803.1
NP_001308804.1
NP_001308805.1
NP_001308806.1
NP_001308807.1
NP_001308808.1
NP_001308813.1
NP_001308814.1
NP_001308815.1
NP_001308816.1
NP_001308817.1
NP_001308818.1
NP_001308819.1
NP_001308820.1
NP_001308822.1
NP_001308823.1
NP_001308824.1
NP_001308825.1
NP_001308826.1
NP_001308827.1
NP_001308828.1
NP_001308829.1
NP_001308830.1
NP_001308831.1
NP_055522.1
NP_478056.1
NP_848510.1
NP_848512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023250.3 RefSeqGene

    Range
    413801..920468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204144.3 → NP_001191073.1  histone deacetylase 9 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001191073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is longer at the N-terminus, has a shorter and distinct C-terminus, and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AC074193, AK304298, BC150328, DC333353
    Consensus CDS
    CCDS56465.1
    UniProtKB/TrEMBL
    A0A9L9PY89
    Related
    ENSP00000401669.2, ENST00000417496.6
    Conserved Domains (1) summary
    cl25407
    Location:80 → 166
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  2. NM_001204145.3 → NP_001191074.1  histone deacetylase 9 isoform 7

    See identical proteins and their annotated locations for NP_001191074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an extended 5' UTR, differs in the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus and lacks an internal segment compared to isoform 1. Variants 7, 30 and 31 encode the same isoform (7).
    Source sequence(s)
    AC002433, AK297404, BC150328, DC333611
    Consensus CDS
    CCDS56466.1
    UniProtKB/TrEMBL
    A0A9L9PY89
    Related
    ENSP00000395655.2, ENST00000428307.6
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. NM_001204146.2 → NP_001191075.1  histone deacetylase 9 isoform 8

    See identical proteins and their annotated locations for NP_001191075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an extended 5' UTR, differs in the 3' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (8) has a shorter and distinct C-terminus, lacks an internal segment, and contains an alternate short internal segment compared to isoform 1.
    Source sequence(s)
    AC002433, AK316109, BC150328, DC333611
    Consensus CDS
    CCDS75565.1
    UniProtKB/TrEMBL
    A0A9L9PY89, B7Z3P7
    Related
    ENSP00000478829.1, ENST00000622668.4
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  4. NM_001204147.3 → NP_001191076.1  histone deacetylase 9 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (9) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AC002433, AK304343, AK304410, BC150328, DC369899
    Consensus CDS
    CCDS56468.1
    UniProtKB/TrEMBL
    A0A9L9PY89
    Related
    ENSP00000430036.1, ENST00000524023.1
    Conserved Domains (1) summary
    cl25407
    Location:7 → 93
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  5. NM_001204148.3 → NP_001191077.1  histone deacetylase 9 isoform 10

    See identical proteins and their annotated locations for NP_001191077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (10) is shorter at the N-terminus, has a shorter and distinct C-terminus, and contains an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC002124, AC002433, AK304343, AK304410, BC150328, DC369899
    Consensus CDS
    CCDS56467.1
    UniProtKB/TrEMBL
    Q68D71
    Related
    ENSP00000388568.2, ENST00000456174.6
    Conserved Domains (1) summary
    cd10163
    Location:7 → 96
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  6. NM_001321868.2 → NP_001308797.1  histone deacetylase 9 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC004744, AC074193, AJ459808, AK304298, BQ575888, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (2) summary
    cd10163
    Location:60 → 146
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:609 → 986
    HDAC_classIIa; Histone deacetylases, class IIa

  7. NM_001321869.2 → NP_001308798.1  histone deacetylase 9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:60 → 149
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  8. NM_001321870.2 → NP_001308799.1  histone deacetylase 9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
    UniProtKB/TrEMBL
    A0A9L9PXM4
    Conserved Domains (1) summary
    cl25407
    Location:60 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  9. NM_001321871.2 → NP_001308800.1  histone deacetylase 9 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC002433, AC074193, AK304298, BC150328, DC333353
    UniProtKB/TrEMBL
    A0A9L9PXL9, A0A9L9PY89
    Related
    ENSP00000516728.1, ENST00000707077.1
    Conserved Domains (1) summary
    cl25407
    Location:60 → 146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  10. NM_001321872.2 → NP_001308801.1  histone deacetylase 9 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cd10163
    Location:60 → 149
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  11. NM_001321873.2 → NP_001308802.1  histone deacetylase 9 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC074193, AK304298, AK316109, BC150328, DC333353
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cd10163
    Location:60 → 149
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  12. NM_001321874.2 → NP_001308803.1  histone deacetylase 9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  13. NM_001321875.2 → NP_001308804.1  histone deacetylase 9 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  14. NM_001321876.2 → NP_001308805.1  histone deacetylase 9 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS94058.1
    UniProtKB/TrEMBL
    A0A7P0T8F4, A0A9L9PY57
    Related
    ENSP00000505081.1, ENST00000681950.1
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  15. NM_001321877.2 → NP_001308806.1  histone deacetylase 9 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC002088, AC002124, AC002410, AC002433, AC004744, AC004994, BQ575888, DC333611
    Consensus CDS
    CCDS83163.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000383912.1, ENST00000401921.5
    Conserved Domains (2) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:590 → 967
    HDAC_classIIa; Histone deacetylases, class IIa

  16. NM_001321878.2 → NP_001308807.1  histone deacetylase 9 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS94059.1
    UniProtKB/TrEMBL
    A0A7P0TAB5, Q68D71
    Related
    ENSP00000506070.1, ENST00000681273.1
    Conserved Domains (1) summary
    cl23765
    Location:38 → 124
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  17. NM_001321879.2 → NP_001308808.1  histone deacetylase 9 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  18. NM_001321884.2 → NP_001308813.1  histone deacetylase 9 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  19. NM_001321885.2 → NP_001308814.1  histone deacetylase 9 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  20. NM_001321886.2 → NP_001308815.1  histone deacetylase 9 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cl23765
    Location:7 → 93
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  21. NM_001321887.2 → NP_001308816.1  histone deacetylase 9 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:7 → 96
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  22. NM_001321888.2 → NP_001308817.1  histone deacetylase 9 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/TrEMBL
    A0A9L9PY89
    Related
    ENSP00000516732.1, ENST00000707081.1
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  23. NM_001321889.2 → NP_001308818.1  histone deacetylase 9 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cd10163
    Location:7 → 96
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  24. NM_001321890.2 → NP_001308819.1  histone deacetylase 9 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  25. NM_001321891.2 → NP_001308820.1  histone deacetylase 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS56466.1
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  26. NM_001321893.2 → NP_001308822.1  histone deacetylase 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    Consensus CDS
    CCDS56466.1
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  27. NM_001321894.2 → NP_001308823.1  histone deacetylase 9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS75565.1
    UniProtKB/TrEMBL
    A0A9L9PY89, B7Z3P7
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  28. NM_001321895.2 → NP_001308824.1  histone deacetylase 9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS75565.1
    UniProtKB/TrEMBL
    A0A9L9PY89, B7Z3P7
    Related
    ENSP00000384017.1, ENST00000406072.5
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  29. NM_001321896.2 → NP_001308825.1  histone deacetylase 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, AC091697, BC150328
    Consensus CDS
    CCDS56467.1
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:7 → 96
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  30. NM_001321897.2 → NP_001308826.1  histone deacetylase 9 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC002088, AC002124, AC002410, AC002433, AC004744, AC004994, BQ575888, DC333611
    Consensus CDS
    CCDS83163.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (2) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:590 → 967
    HDAC_classIIa; Histone deacetylases, class IIa

  31. NM_001321898.2 → NP_001308827.1  histone deacetylase 9 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/TrEMBL
    A0A9L9PY89
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  32. NM_001321899.2 → NP_001308828.1  histone deacetylase 9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  33. NM_001321900.2 → NP_001308829.1  histone deacetylase 9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS47557.1
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  34. NM_001321901.2 → NP_001308830.1  histone deacetylase 9 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  35. NM_001321902.2 → NP_001308831.1  histone deacetylase 9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/TrEMBL
    Q68D71
    Conserved Domains (1) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

  36. NM_014707.4 → NP_055522.1  histone deacetylase 9 isoform 3

    See identical proteins and their annotated locations for NP_055522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and has an alternate 3' segment including the coding region and UTR, compared to variant 1. The resulting isoform 3, also known as HDRP, has a much shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC152405
    Consensus CDS
    CCDS47557.1
    UniProtKB/TrEMBL
    Q68D71
    Related
    ENSP00000384382.3, ENST00000405010.7
    Conserved Domains (1) summary
    cl25407
    Location:38 → 124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  37. NM_058176.2 → NP_478056.1  histone deacetylase 9 isoform 1

    See identical proteins and their annotated locations for NP_478056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AA405905, AY032737, BC152405
    Consensus CDS
    CCDS47555.1
    UniProtKB/Swiss-Prot
    A7E2F3, B7Z4I4, B7Z917, B7Z928, B7Z940, C9JS87, E7EX34, F8W9E0, O94845, O95028, Q2M2R6, Q86SL1, Q86US3, Q9UKV0
    Related
    ENSP00000410337.2, ENST00000432645.6
    Conserved Domains (2) summary
    cd10163
    Location:38 → 124
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd10009
    Location:631 → 1009
    HDAC9; Histone deacetylase 9

  38. NM_178423.3 → NP_848510.1  histone deacetylase 9 isoform 4

    See identical proteins and their annotated locations for NP_848510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 3' sequence including the coding region and UTR, compared to variant 1. The resulting isoform 4, also known as HDAC9fl, has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004744, AJ459808, BQ575888
    Consensus CDS
    CCDS47554.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000384657.3, ENST00000406451.8
    Conserved Domains (2) summary
    cd10163
    Location:38 → 124
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:631 → 1008
    HDAC_classIIa; Histone deacetylases, class IIa

  39. NM_178425.4 → NP_848512.1  histone deacetylase 9 isoform 5

    See identical proteins and their annotated locations for NP_848512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 3' sequence including the coding region and UTR, compared to variant 1. The resulting isoform 5 has a distinct C-terminus, compared to isoform 1. This variant is incomplete at the 5' end.
    Source sequence(s)
    AC002088, AC002124, AC002410, AC002433, AC004744, AC004994
    Consensus CDS
    CCDS47553.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000509161.1, ENST00000686413.1
    Conserved Domains (2) summary
    cd10163
    Location:38 → 127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:634 → 1011
    HDAC_classIIa; Histone deacetylases, class IIa

RNA

  1. NR_135835.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002433, BC092441, DC333611

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    18086825..19002416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    18216502..19132425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_058177.2: Suppressed sequence

    Description
    NM_058177.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UKV0.2 GenPept UniProtKB/Swiss-Prot:Q9UKV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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