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RIMS2 regulating synaptic membrane exocytosis 2 [ Homo sapiens (human) ]

Gene ID: 9699, updated on 7-Apr-2024

Summary

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Official Symbol
RIMS2provided by HGNC
Official Full Name
regulating synaptic membrane exocytosis 2provided by HGNC
Primary source
HGNC:HGNC:17283
See related
Ensembl:ENSG00000176406 MIM:606630; AllianceGenome:HGNC:17283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBOE; RIM2; CRSDS; RAB3IP3
Summary
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Expression
Biased expression in adrenal (RPKM 12.7), brain (RPKM 6.8) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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Location:
8q22.3
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (103500610..104256094)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (104628208..105383642)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104512838..105268322)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104427001-104427622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:104430836-104431727 Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19459 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:104577723-104577885 Neighboring gene mediator complex subunit 21 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:104620341-104620931 Neighboring gene prothymosin alpha pseudogene 15 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:104636023-104636786 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:104638899-104639435 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:104658118-104658714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:104663069-104663834 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:104687894-104688721 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:104688722-104689548 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104719477-104719978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104719979-104720478 Neighboring gene TARBP2 pseudogene 1 Neighboring gene ribosomal protein S6 pseudogene 9 Neighboring gene uncharacterized LOC105375689 Neighboring gene Sharpr-MPRA regulatory region 520 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:105041517-105042017 Neighboring gene uncharacterized LOC107984007 Neighboring gene uncharacterized LOC105375688 Neighboring gene NANOG hESC enhancer GRCh37_chr8:105094952-105095475 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:105220085-105220238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27792 Neighboring gene uncharacterized LOC124902065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:105295895-105296650 Neighboring gene uncharacterized LOC107986899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement. Mechaussier S, et al. Am J Hum Genet, 2020 Jun 4. PMID 32470375, Free PMC Article
  2. Association between regulating synaptic membrane exocytosis 2 gene polymorphisms and degenerative lumbar scoliosis. Kim KT, et al. Biomed Rep, 2013 Jul. PMID 24648997, Free PMC Article
  3. Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism. Ellencrona K, et al. Biol Chem, 2009 Apr. PMID 19199833
  4. Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs. Weidenhofer J, et al. J Psychiatr Res, 2009 Jan. PMID 18490030
  5. Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection. Gérard HC, et al. Ann Rheum Dis, 2006 Mar. PMID 16192289, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.
    Title: Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.
  2. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
    Title: C-terminal splice variants of P/Q-type Ca(2+) channel Ca(V)2.1 α(1) subunits are differentially regulated by Rab3-interacting molecule proteins.
  3. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
    Title: RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
  4. These data suggest that RIM2beta contributes to the stabilization of Ca(v)1.3 gating kinetics in immature cochlear inner hair cells.
    Title: Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. tick-borne encephalitis virus -NS5 has high affinity to regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble, whereas DENV-NS5 binds primarily to the tight junction protein zonula occludens-1 (ZO-1)
    Title: Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism.
  8. Western blot analysis shows increased RIMS2 protein expression in the amygdala in schizophrenia.
    Title: Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cone-rod synaptic disorder syndrome, congenital nonprogressive
MedGen: C5436505 OMIM: 618970 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0751, DKFZp781A0653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion-regulated exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spontaneous neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in presynaptic active zone TAS
Traceable Author Statement
more info
 PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
regulating synaptic membrane exocytosis protein 2
Names
RAB3 interacting protein 3
Rab3-interacting protein
non-small cell lung cancer RimL3a protein
non-small cell lung cancer RimL3c protein
nuclear protein
rab-3-interacting molecule 2
rab-3-interacting protein 3
rab3-interacting molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053027.1 RefSeqGene

    Range
    5585..759405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100117.3 → NP_001093587.1  regulating synaptic membrane exocytosis protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC012213, AK126939, AP002849, BC043144
    Consensus CDS
    CCDS55269.1
    UniProtKB/TrEMBL
    A0A994J7I0
    Related
    ENSP00000427018.3, ENST00000504942.6
    Conserved Domains (4) summary
    cd04028
    Location:1180 → 1325
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:746 → 869
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593 → 674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  2. NM_001282881.2 → NP_001269810.1  regulating synaptic membrane exocytosis protein 2 isoform c

    See identical proteins and their annotated locations for NP_001269810.1

    Status: REVIEWED

    Source sequence(s)
    AB018294, AP002849, BP230765
    Consensus CDS
    CCDS64948.1
    UniProtKB/TrEMBL
    A0A994J7I6
    Related
    ENSP00000262231.10, ENST00000262231.14
    Conserved Domains (3) summary
    cd04028
    Location:1019 → 1164
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582 → 708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. NM_001282882.2 → NP_001269811.1  regulating synaptic membrane exocytosis protein 2 isoform d

    See identical proteins and their annotated locations for NP_001269811.1

    Status: REVIEWED

    Source sequence(s)
    AP002849, BP360433, CN361794
    Consensus CDS
    CCDS64949.1
    UniProtKB/TrEMBL
    E5RI36
    Related
    ENSP00000428478.2, ENST00000523362.6
    Conserved Domains (1) summary
    cd04028
    Location:116 → 261
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

  4. NM_001348484.3 → NP_001335413.1  regulating synaptic membrane exocytosis protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (e).
    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Consensus CDS
    CCDS94327.1
    UniProtKB/TrEMBL
    A0A8Q3SIU4, A0A994J4Z8
    Related
    ENSP00000512879.1, ENST00000696799.1
    Conserved Domains (4) summary
    cd04028
    Location:1438 → 1583
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:818 → 944
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:684 → 765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 198
    PHD_SF; PHD finger superfamily

  5. NM_001348485.2 → NP_001335414.1  regulating synaptic membrane exocytosis protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7W5
    Related
    ENSP00000516181.1, ENST00000705944.1
    Conserved Domains (4) summary
    cd04028
    Location:1104 → 1249
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727 → 853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593 → 674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  6. NM_001348486.2 → NP_001335415.1  regulating synaptic membrane exocytosis protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/Swiss-Prot
    B3KX91, F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1, Q9UQ26
    Conserved Domains (4) summary
    cd04028
    Location:1237 → 1382
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:778 → 904
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:644 → 725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 158
    PHD_SF; PHD finger superfamily

  7. NM_001348487.2 → NP_001335416.1  regulating synaptic membrane exocytosis protein 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I0
    Related
    ENSP00000512880.1, ENST00000696800.1
    Conserved Domains (4) summary
    cd04028
    Location:1190 → 1335
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731 → 857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 158
    PHD_SF; PHD finger superfamily

  8. NM_001348488.2 → NP_001335417.1  regulating synaptic membrane exocytosis protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J590
    Related
    ENSP00000516185.1, ENST00000705948.1
    Conserved Domains (4) summary
    cd04028
    Location:1208 → 1353
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771 → 897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637 → 718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 198
    PHD_SF; PHD finger superfamily

  9. NM_001348489.2 → NP_001335418.1  regulating synaptic membrane exocytosis protein 2 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A590UJL1
    Related
    ENSP00000499454.1, ENST00000666250.1
    Conserved Domains (4) summary
    cd04028
    Location:1380 → 1525
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727 → 853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593 → 674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  10. NM_001348490.2 → NP_001335419.1  regulating synaptic membrane exocytosis protein 2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J4Z8
    Related
    ENSP00000516179.1, ENST00000705942.1
    Conserved Domains (4) summary
    cd04028
    Location:1351 → 1496
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731 → 857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 158
    PHD_SF; PHD finger superfamily

  11. NM_001348491.2 → NP_001335420.1  regulating synaptic membrane exocytosis protein 2 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/Swiss-Prot
    B3KX91, F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1, Q9UQ26
    Related
    ENSP00000499719.1, ENST00000668113.1
    Conserved Domains (5) summary
    cd04028
    Location:1251 → 1396
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:814 → 940
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:680 → 761
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 194
    PHD_SF; PHD finger superfamily
    cl28890
    Location:148 → 192
    FYVE_like_SF; FYVE domain like superfamily

  12. NM_001348492.2 → NP_001335421.1  regulating synaptic membrane exocytosis protein 2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I0
    Related
    ENSP00000516178.1, ENST00000705941.1
    Conserved Domains (4) summary
    cd04028
    Location:1179 → 1324
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731 → 857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 158
    PHD_SF; PHD finger superfamily

  13. NM_001348493.2 → NP_001335422.1  regulating synaptic membrane exocytosis protein 2 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I0
    Conserved Domains (4) summary
    cd04028
    Location:1164 → 1309
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727 → 853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593 → 674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  14. NM_001348494.2 → NP_001335423.1  regulating synaptic membrane exocytosis protein 2 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Consensus CDS
    CCDS94328.1
    UniProtKB/Swiss-Prot
    B3KX91, F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1, Q9UQ26
    UniProtKB/TrEMBL
    A0A994J5M6
    Related
    ENSP00000516184.1, ENST00000705947.1
    Conserved Domains (4) summary
    cd04028
    Location:1233 → 1378
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774 → 900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640 → 721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  15. NM_001348495.2 → NP_001335424.1  regulating synaptic membrane exocytosis protein 2 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I0
    Conserved Domains (4) summary
    cd04028
    Location:1189 → 1334
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:741 → 867
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:607 → 688
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  16. NM_001348496.2 → NP_001335425.1  regulating synaptic membrane exocytosis protein 2 isoform q

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I0
    Conserved Domains (4) summary
    cd04028
    Location:1168 → 1313
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731 → 857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 158
    PHD_SF; PHD finger superfamily

  17. NM_001348497.2 → NP_001335426.1  regulating synaptic membrane exocytosis protein 2 isoform r

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7W5
    Conserved Domains (4) summary
    cd04028
    Location:1162 → 1307
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774 → 900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640 → 721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  18. NM_001348498.2 → NP_001335427.1  regulating synaptic membrane exocytosis protein 2 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Consensus CDS
    CCDS94331.1
    UniProtKB/TrEMBL
    A0A8Q3SJ53, A0A994J7I6
    Related
    ENSP00000512882.1, ENST00000696802.1
    Conserved Domains (3) summary
    cd04028
    Location:1155 → 1300
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  19. NM_001348499.2 → NP_001335428.1  regulating synaptic membrane exocytosis protein 2 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Conserved Domains (3) summary
    cd04028
    Location:1016 → 1161
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  20. NM_001348500.2 → NP_001335429.1  regulating synaptic membrane exocytosis protein 2 isoform u

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Consensus CDS
    CCDS94330.1
    UniProtKB/TrEMBL
    A0A994J7I6, A0A994J7W6
    Related
    ENSP00000516186.1, ENST00000705949.1
    Conserved Domains (3) summary
    cd04028
    Location:934 → 1079
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  21. NM_001348501.2 → NP_001335430.1  regulating synaptic membrane exocytosis protein 2 isoform v

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    D6RA03
    Related
    ENSP00000390665.2, ENST00000436393.6
    Conserved Domains (3) summary
    cd04028
    Location:1106 → 1251
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  22. NM_001348502.2 → NP_001335431.1  regulating synaptic membrane exocytosis protein 2 isoform w

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Consensus CDS
    CCDS94332.1
    UniProtKB/TrEMBL
    A0A994J503, A0A994J7I6
    Related
    ENSP00000516187.1, ENST00000705950.1
    Conserved Domains (3) summary
    cd04028
    Location:912 → 1057
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  23. NM_001348503.2 → NP_001335432.1  regulating synaptic membrane exocytosis protein 2 isoform x

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Conserved Domains (3) summary
    cd04028
    Location:1155 → 1300
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  24. NM_001348504.2 → NP_001335433.1  regulating synaptic membrane exocytosis protein 2 isoform y

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Conserved Domains (3) summary
    cd04028
    Location:939 → 1084
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:554 → 677
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  25. NM_001348505.2 → NP_001335434.1  regulating synaptic membrane exocytosis protein 2 isoform z

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Conserved Domains (3) summary
    cd04028
    Location:1041 → 1186
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582 → 708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  26. NM_001348506.2 → NP_001335435.1  regulating synaptic membrane exocytosis protein 2 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Conserved Domains (3) summary
    cd04028
    Location:972 → 1117
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  27. NM_001348507.2 → NP_001335436.1  regulating synaptic membrane exocytosis protein 2 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Conserved Domains (3) summary
    cd04028
    Location:988 → 1133
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:554 → 677
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  28. NM_001348508.2 → NP_001335437.1  regulating synaptic membrane exocytosis protein 2 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J7I6
    Related
    ENSP00000516188.1, ENST00000705951.1
    Conserved Domains (3) summary
    cd04028
    Location:983 → 1128
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  29. NM_001348509.2 → NP_001335438.1  regulating synaptic membrane exocytosis protein 2 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Consensus CDS
    CCDS94329.1
    UniProtKB/TrEMBL
    D6RA03, F8W6W8
    Related
    ENSP00000386228.3, ENST00000408894.7

  30. NM_001395652.1 → NP_001382581.1  regulating synaptic membrane exocytosis protein 2 isoform ee

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J4Z8
    Conserved Domains (4) summary
    cd04028
    Location:1389 → 1534
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:750 → 873
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28890
    Location:108 → 156
    FYVE_like_SF; FYVE domain like superfamily

  31. NM_001395653.1 → NP_001382582.1  regulating synaptic membrane exocytosis protein 2 isoform ff

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J5M2
    Conserved Domains (4) summary
    cd04028
    Location:1342 → 1487
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771 → 897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637 → 718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28890
    Location:148 → 196
    FYVE_like_SF; FYVE domain like superfamily

  32. NM_001395654.1 → NP_001382583.1  regulating synaptic membrane exocytosis protein 2 isoform gg

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    UniProtKB/TrEMBL
    A0A994J4Z8
    Conserved Domains (4) summary
    cd04028
    Location:1391 → 1536
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771 → 897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637 → 718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28890
    Location:148 → 196
    FYVE_like_SF; FYVE domain like superfamily

  33. NM_014677.5 → NP_055492.3  regulating synaptic membrane exocytosis protein 2 isoform b

    See identical proteins and their annotated locations for NP_055492.3

    Status: REVIEWED

    Source sequence(s)
    AK126939, AP002849, BC043144, BP230765
    Consensus CDS
    CCDS43761.1
    UniProtKB/TrEMBL
    A0A994J7I6
    Related
    ENSP00000423559.1, ENST00000507740.6
    Conserved Domains (4) summary
    cd04028
    Location:994 → 1139
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535 → 661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:762 → 864
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:401 → 482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. NR_145710.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849

  2. NR_145711.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    103500610..104256094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014015.3 → XP_016869504.1  regulating synaptic membrane exocytosis protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A994J4Z8

  2. XM_017014010.3 → XP_016869499.1  regulating synaptic membrane exocytosis protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A994J586

  3. XM_017014016.3 → XP_016869505.1  regulating synaptic membrane exocytosis protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A994J4Z8

  4. XM_047422473.1 → XP_047278429.1  regulating synaptic membrane exocytosis protein 2 isoform X9

  5. XM_017014009.3 → XP_016869498.1  regulating synaptic membrane exocytosis protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A994J4Z8

  6. XM_011517395.4 → XP_011515697.1  regulating synaptic membrane exocytosis protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A994J4Z8
    Conserved Domains (4) summary
    cd04028
    Location:1541 → 1686
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851 → 974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698 → 779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 198
    PHD_SF; PHD finger superfamily

  7. XM_017014008.3 → XP_016869497.1  regulating synaptic membrane exocytosis protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A994J586

  8. XM_017014006.3 → XP_016869495.1  regulating synaptic membrane exocytosis protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A994J4Z8

  9. XM_017014011.3 → XP_016869500.1  regulating synaptic membrane exocytosis protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A994J4Z8

  10. XM_047422468.1 → XP_047278424.1  regulating synaptic membrane exocytosis protein 2 isoform X3

  11. XM_017014012.3 → XP_016869501.1  regulating synaptic membrane exocytosis protein 2 isoform X16

    UniProtKB/TrEMBL
    A0A994J4Z8

  12. XM_047422469.1 → XP_047278425.1  regulating synaptic membrane exocytosis protein 2 isoform X4

  13. XM_047422475.1 → XP_047278431.1  regulating synaptic membrane exocytosis protein 2 isoform X14

  14. XM_047422476.1 → XP_047278432.1  regulating synaptic membrane exocytosis protein 2 isoform X15

  15. XM_047422477.1 → XP_047278433.1  regulating synaptic membrane exocytosis protein 2 isoform X17

  16. XM_047422481.1 → XP_047278437.1  regulating synaptic membrane exocytosis protein 2 isoform X26

  17. XM_047422470.1 → XP_047278426.1  regulating synaptic membrane exocytosis protein 2 isoform X6

  18. XM_047422471.1 → XP_047278427.1  regulating synaptic membrane exocytosis protein 2 isoform X7

  19. XM_047422472.1 → XP_047278428.1  regulating synaptic membrane exocytosis protein 2 isoform X8

  20. XM_047422480.1 → XP_047278436.1  regulating synaptic membrane exocytosis protein 2 isoform X24

  21. XM_047422479.1 → XP_047278435.1  regulating synaptic membrane exocytosis protein 2 isoform X19

  22. XM_017014014.2 → XP_016869503.1  regulating synaptic membrane exocytosis protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A994J4Z8

  23. XM_047422482.1 → XP_047278438.1  regulating synaptic membrane exocytosis protein 2 isoform X27

    Related
    ENSP00000516182.1, ENST00000705945.1

  24. XM_047422478.1 → XP_047278434.1  regulating synaptic membrane exocytosis protein 2 isoform X18

  25. XM_005251106.4 → XP_005251163.1  regulating synaptic membrane exocytosis protein 2 isoform X23

    UniProtKB/TrEMBL
    A0A994J4Z8
    Conserved Domains (5) summary
    cd04028
    Location:1405 → 1550
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774 → 900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:1001 → 1103
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:640 → 721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  26. XM_047422474.1 → XP_047278430.1  regulating synaptic membrane exocytosis protein 2 isoform X11

  27. XM_005251107.4 → XP_005251164.1  regulating synaptic membrane exocytosis protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A994J4Z8
    Conserved Domains (4) summary
    cd04028
    Location:1383 → 1528
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774 → 900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640 → 721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30 → 154
    PHD_SF; PHD finger superfamily

  28. XM_047422483.1 → XP_047278439.1  regulating synaptic membrane exocytosis protein 2 isoform X29

  29. XM_017014036.2 → XP_016869525.1  regulating synaptic membrane exocytosis protein 2 isoform X30

    UniProtKB/TrEMBL
    D6RA03

  30. XM_017014022.2 → XP_016869511.1  regulating synaptic membrane exocytosis protein 2 isoform X28

    UniProtKB/TrEMBL
    D6RA03

  31. XM_006716698.4 → XP_006716761.1  regulating synaptic membrane exocytosis protein 2 isoform X31

    Conserved Domains (1) summary
    cd04028
    Location:144 → 289
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    104628208..105383642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361590.1 → XP_054217565.1  regulating synaptic membrane exocytosis protein 2 isoform X21

  2. XM_054361581.1 → XP_054217556.1  regulating synaptic membrane exocytosis protein 2 isoform X12

  3. XM_054361591.1 → XP_054217566.1  regulating synaptic membrane exocytosis protein 2 isoform X22

  4. XM_054361578.1 → XP_054217553.1  regulating synaptic membrane exocytosis protein 2 isoform X9

  5. XM_054361579.1 → XP_054217554.1  regulating synaptic membrane exocytosis protein 2 isoform X10

  6. XM_054361570.1 → XP_054217545.1  regulating synaptic membrane exocytosis protein 2 isoform X1

  7. XM_054361574.1 → XP_054217549.1  regulating synaptic membrane exocytosis protein 2 isoform X5

  8. XM_054361571.1 → XP_054217546.1  regulating synaptic membrane exocytosis protein 2 isoform X2

  9. XM_054361582.1 → XP_054217557.1  regulating synaptic membrane exocytosis protein 2 isoform X13

  10. XM_054361572.1 → XP_054217547.1  regulating synaptic membrane exocytosis protein 2 isoform X3

  11. XM_054361585.1 → XP_054217560.1  regulating synaptic membrane exocytosis protein 2 isoform X16

  12. XM_054361573.1 → XP_054217548.1  regulating synaptic membrane exocytosis protein 2 isoform X4

  13. XM_054361583.1 → XP_054217558.1  regulating synaptic membrane exocytosis protein 2 isoform X14

  14. XM_054361584.1 → XP_054217559.1  regulating synaptic membrane exocytosis protein 2 isoform X15

  15. XM_054361586.1 → XP_054217561.1  regulating synaptic membrane exocytosis protein 2 isoform X17

  16. XM_054361595.1 → XP_054217570.1  regulating synaptic membrane exocytosis protein 2 isoform X26

  17. XM_054361575.1 → XP_054217550.1  regulating synaptic membrane exocytosis protein 2 isoform X6

  18. XM_054361576.1 → XP_054217551.1  regulating synaptic membrane exocytosis protein 2 isoform X7

  19. XM_054361577.1 → XP_054217552.1  regulating synaptic membrane exocytosis protein 2 isoform X8

  20. XM_054361593.1 → XP_054217568.1  regulating synaptic membrane exocytosis protein 2 isoform X24

  21. XM_054361588.1 → XP_054217563.1  regulating synaptic membrane exocytosis protein 2 isoform X19

  22. XM_054361589.1 → XP_054217564.1  regulating synaptic membrane exocytosis protein 2 isoform X20

  23. XM_054361596.1 → XP_054217571.1  regulating synaptic membrane exocytosis protein 2 isoform X27

  24. XM_054361587.1 → XP_054217562.1  regulating synaptic membrane exocytosis protein 2 isoform X18

  25. XM_054361592.1 → XP_054217567.1  regulating synaptic membrane exocytosis protein 2 isoform X23

  26. XM_054361580.1 → XP_054217555.1  regulating synaptic membrane exocytosis protein 2 isoform X11

  27. XM_054361594.1 → XP_054217569.1  regulating synaptic membrane exocytosis protein 2 isoform X25

  28. XM_054361598.1 → XP_054217573.1  regulating synaptic membrane exocytosis protein 2 isoform X29

  29. XM_054361599.1 → XP_054217574.1  regulating synaptic membrane exocytosis protein 2 isoform X30

  30. XM_054361597.1 → XP_054217572.1  regulating synaptic membrane exocytosis protein 2 isoform X28

  31. XM_054361600.1 → XP_054217575.1  regulating synaptic membrane exocytosis protein 2 isoform X31

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UQ26.2 GenPept UniProtKB/Swiss-Prot:Q9UQ26

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