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PDE4DIP phosphodiesterase 4D interacting protein [ Homo sapiens (human) ]

Gene ID: 9659, updated on 5-Mar-2024

Summary

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Official Symbol
PDE4DIPprovided by HGNC
Official Full Name
phosphodiesterase 4D interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:15580
See related
Ensembl:ENSG00000178104 MIM:608117; AllianceGenome:HGNC:15580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMGL; CMYA2
Summary
The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Expression
Biased expression in heart (RPKM 86.3), brain (RPKM 18.4) and 10 other tissues See more
Orthologs
all
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Genomic context

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See PDE4DIP in Genome Data Viewer
Location:
1q21.2
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (148808434..149033016)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145475230..145700086)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (144851427..145075933, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:145116171-145116728 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:145115612-145116170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145111649-145112460 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:145108701-145108867 Neighboring gene nudix hydrolase 4B Neighboring gene SEC22 homolog B3, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:145085325-145085826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145075157-145075794 Neighboring gene NANOG hESC enhancer GRCh37_chr1:145058822-145059364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145047676-145048176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145039786-145040507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145039063-145039785 Neighboring gene NANOG hESC enhancer GRCh37_chr1:145028802-145029303 Neighboring gene RN7SK pseudogene 88 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145023082-145023696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145022466-145023081 Neighboring gene uncharacterized LOC112268272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145015143-145015643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144994512-144995132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144993892-144994511 Neighboring gene NANOG hESC enhancer GRCh37_chr1:144976465-144977040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144966957-144967786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:144961997-144962606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144937763-144938539 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:144936334-144936835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144932913-144933661 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:144931414-144932162 and GRCh37_chr1:144932163-144932912 Neighboring gene RNA, U2 small nuclear 38, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:144891435-144892634 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:144867459-144868658 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144850469-144850968 Neighboring gene profilin-1-like Neighboring gene NBPF member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1288 Neighboring gene uncharacterized LOC101929790

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis. Pan R, et al. Cell Death Dis, 2023 Jun 24. PMID 37355626, Free PMC Article
  2. Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene. Potashkin JA, et al. Int J Mol Sci, 2020 May 27. PMID 32471155, Free PMC Article
  3. Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. Shimada H, et al. Int J Oncol, 2007 Jan. PMID 17143517
  4. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction. Abou Ziki MD, et al. Hum Mutat, 2021 Oct. PMID 34289528, Free PMC Article
  5. Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome. Peng H, et al. Mol Biol Cell, 2021 Sep 1. PMID 34260267, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis.
    Title: PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis.
  2. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.
    Title: Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.
  3. Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
    Title: Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
  4. Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene.
    Title: Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene.
  5. analysis of the recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
    Title: Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.
  6. A specific isoform of myomegalin, termed "SMYLE," promotes microtubule assembly and function.
    Title: EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.
  7. PDE4DIP genetic variation was associated with increased risk for ischemic stroke.
    Title: Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
  8. A role of the SANS-myomegalin complex in microtubule-dependent inner segment cargo transport towards the ciliary base of photoreceptor cells.
    Title: Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. MMGL-antibody is significantly with a favorable prognosis. Consequently, MMGL-anatibodies may be a useful tumor marker to diagnose and establish a prognosis in patients with esophageal squamous cell carcinoma.
    Title: Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of novel germline polymorphisms governing capecitabine sensitivity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC75440, DKFZp781J054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Golgi organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myomegalin
Names
cardiomyopathy-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027693.2 RefSeqGene

    Range
    41253..229841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002810.5 → NP_001002810.1  myomegalin isoform 4

    See identical proteins and their annotated locations for NP_001002810.1

    Status: REVIEWED

    Source sequence(s)
    AC239802
    Consensus CDS
    CCDS72893.1
    UniProtKB/TrEMBL
    Q8TBR0
    Related
    ENSP00000358353.4, ENST00000369347.8
    Conserved Domains (2) summary
    pfam07989
    Location:6 → 73
    Cnn_1N; Centrosomin N-terminal motif 1
    cl26527
    Location:39 → 135
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein

  2. NM_001002811.3 → NP_001002811.2  myomegalin isoform 5

    See identical proteins and their annotated locations for NP_001002811.2

    Status: REVIEWED

    Source sequence(s)
    AC239802
    Consensus CDS
    CCDS72894.1
    UniProtKB/Swiss-Prot
    Q5VU43
    Related
    ENSP00000316434.9, ENST00000313431.13
    Conserved Domains (2) summary
    pfam07776
    Location:4 → 74
    zf-AD; Zinc-finger associated domain (zf-AD)
    cl25732
    Location:403 → 1095
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001002812.4 → NP_001002812.2  myomegalin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC239802
    Consensus CDS
    CCDS72890.1
    UniProtKB/Swiss-Prot
    Q5VU43
    UniProtKB/TrEMBL
    A0A0A0MRL8
    Related
    ENSP00000358355.3, ENST00000369349.7
    Conserved Domains (3) summary
    TIGR02168
    Location:30 → 679
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07851
    Location:242 → 337
    TMPIT; TMPIT-like protein
    pfam07989
    Location:6 → 73
    Cnn_1N; Centrosomin N-terminal motif 1

  4. NM_001195260.2 → NP_001182189.1  myomegalin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC239802, BC025406, BI550399, CB529851, DA766011
    UniProtKB/Swiss-Prot
    Q5VU43
    Conserved Domains (2) summary
    PRK12704
    Location:2 → 113
    PRK12704; phosphodiesterase; Provisional
    pfam07989
    Location:1 → 41
    Cnn_1N; Centrosomin N-terminal motif 1

  5. NM_001195261.2 → NP_001182190.1  myomegalin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC239802, BC025406, BG776644, CB529851, DA766011
    UniProtKB/TrEMBL
    E9PS60
    Related
    ENSP00000435920.1, ENST00000534536.5
    Conserved Domains (2) summary
    pfam07989
    Location:13 → 76
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam16046
    Location:53 → 118
    FAM76; FAM76 protein

  6. NM_001198832.4 → NP_001185761.2  myomegalin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    Consensus CDS
    CCDS72888.1
    UniProtKB/TrEMBL
    A0A087WX83
    Related
    ENSP00000479409.1, ENST00000618462.4
    Conserved Domains (8) summary
    COG1196
    Location:421 → 1206
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05456
    Location:2009 → 2056
    eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
    pfam06758
    Location:1519 → 1580
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07851
    Location:308 → 403
    TMPIT; TMPIT-like protein
    pfam07989
    Location:72 → 139
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam15678
    Location:1823 → 1886
    SPICE; Centriole duplication and mitotic chromosome congression
    cl09111
    Location:116 → 233
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  7. NM_001198834.5 → NP_001185763.3  myomegalin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    Consensus CDS
    CCDS72892.1
    UniProtKB/TrEMBL
    A0A087WX83
    Related
    ENSP00000358363.4, ENST00000369356.8
    Conserved Domains (7) summary
    TIGR02168
    Location:5 → 679
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05456
    Location:2115 → 2162
    eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
    pfam06758
    Location:1563 → 1624
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07851
    Location:242 → 337
    TMPIT; TMPIT-like protein
    pfam07989
    Location:6 → 73
    Cnn_1N; Centrosomin N-terminal motif 1
    pfam15678
    Location:1929 → 1992
    SPICE; Centriole duplication and mitotic chromosome congression
    cl09111
    Location:50 → 167
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  8. NM_001350520.2 → NP_001337449.1  myomegalin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    Consensus CDS
    CCDS91044.1
    UniProtKB/TrEMBL
    A0A087WX83, A0A994J5E0
    Related
    ENSP00000516056.1, ENST00000704840.1
    Conserved Domains (3) summary
    pfam06758
    Location:1718 → 1785
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07776
    Location:4 → 74
    zf-AD; Zinc-finger associated domain (zf-AD)
    cl25732
    Location:403 → 1237
    SMC_N; RecF/RecN/SMC N terminal domain

  9. NM_001350521.4 → NP_001337450.1  myomegalin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    pfam06758
    Location:1693 → 1760
    DUF1220; Repeat of unknown function (DUF1220)
    cl25732
    Location:140 → 816
    SMC_N; RecF/RecN/SMC N terminal domain

  10. NM_001350522.3 → NP_001337451.1  myomegalin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A9L9PY76
    Conserved Domains (2) summary
    pfam06758
    Location:1622 → 1689
    DUF1220; Repeat of unknown function (DUF1220)
    cl25732
    Location:69 → 745
    SMC_N; RecF/RecN/SMC N terminal domain

  11. NM_001350523.3 → NP_001337452.1  myomegalin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    pfam06758
    Location:1511 → 1578
    DUF1220; Repeat of unknown function (DUF1220)
    cl25732
    Location:69 → 745
    SMC_N; RecF/RecN/SMC N terminal domain

  12. NM_001377392.2 → NP_001364321.1  myomegalin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    Consensus CDS
    CCDS91040.1
    UniProtKB/TrEMBL
    A0A087WX83, A0A8Q3WM32
    Related
    ENSP00000512174.1, ENST00000695794.1
    Conserved Domains (5) summary
    COG0419
    Location:167 → 767
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1981 → 2203
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:377 → 1175
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1693 → 1760
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:143 → 210
    Cnn_1N; Centrosomin N-terminal motif 1

  13. NM_001377393.2 → NP_001364322.1  myomegalin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (5) summary
    COG0419
    Location:96 → 696
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1800 → 2022
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:306 → 1104
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1512 → 1579
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:72 → 139
    Cnn_1N; Centrosomin N-terminal motif 1

  14. NM_001395297.1 → NP_001382226.1  myomegalin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:2007 → 2229
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:403 → 1237
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  15. NM_001395298.1 → NP_001382227.1  myomegalin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    Consensus CDS
    CCDS91041.1
    UniProtKB/TrEMBL
    A0A075B749, A0A087WX83
    Related
    ENSP00000462316.2, ENST00000585156.5
    Conserved Domains (5) summary
    COG0419
    Location:167 → 767
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1980 → 2202
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:377 → 1175
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1692 → 1759
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:143 → 210
    Cnn_1N; Centrosomin N-terminal motif 1

  16. NM_001395299.1 → NP_001382228.1  myomegalin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1944 → 2166
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:403 → 1201
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  17. NM_001395300.1 → NP_001382229.1  myomegalin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (3) summary
    COG0419
    Location:140 → 730
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:1944 → 2166
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:340 → 1138
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  18. NM_001395301.1 → NP_001382230.1  myomegalin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:2006 → 2175
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:403 → 1201
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  19. NM_001395302.1 → NP_001382231.1  myomegalin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    Consensus CDS
    CCDS91042.1
    UniProtKB/TrEMBL
    A0A087WX83, A0A8Q3SI21
    Related
    ENSP00000512160.1, ENST00000695768.1
    Conserved Domains (3) summary
    COG1196
    Location:1944 → 2113
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:150 → 779
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02463
    Location:495 → 1231
    SMC_N; RecF/RecN/SMC N terminal domain

  20. NM_001395303.1 → NP_001382232.1  myomegalin isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1870 → 2092
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:140 → 816
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  21. NM_001395304.1 → NP_001382233.1  myomegalin isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1848 → 2017
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  22. NM_001395305.1 → NP_001382234.1  myomegalin isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1848 → 2017
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  23. NM_001395306.1 → NP_001382235.1  myomegalin isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1800 → 2022
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  24. NM_001395307.1 → NP_001382236.1  myomegalin isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1870 → 2055
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:140 → 816
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  25. NM_001395308.1 → NP_001382237.1  myomegalin isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A9L9PY76
    Conserved Domains (2) summary
    COG1196
    Location:1847 → 2032
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  26. NM_001395309.1 → NP_001382238.1  myomegalin isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    Conserved Domains (2) summary
    COG1196
    Location:1783 → 2005
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:403 → 1247
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  27. NM_001395310.1 → NP_001382239.1  myomegalin isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A9L9PY76
    Related
    ENSP00000516481.1, ENST00000706647.1
    Conserved Domains (2) summary
    COG1196
    Location:1848 → 2033
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  28. NM_001395311.1 → NP_001382240.1  myomegalin isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:1738 → 1907
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  29. NM_001395312.1 → NP_001382241.1  myomegalin isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A087WX83
    Conserved Domains (2) summary
    COG1196
    Location:421 → 1336
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  30. NM_001395313.1 → NP_001382242.1  myomegalin isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A9L9PY76
    Conserved Domains (2) summary
    COG1196
    Location:1811 → 1996
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:79 → 708
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  31. NM_001395314.1 → NP_001382243.1  myomegalin isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    UniProtKB/TrEMBL
    A0A9L9PY76
    Conserved Domains (2) summary
    COG1196
    Location:421 → 1336
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  32. NM_001395315.1 → NP_001382244.1  myomegalin isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC239802
    Consensus CDS
    CCDS91045.1
    Related
    ENSP00000433392.1, ENST00000529945.2
    Conserved Domains (2) summary
    TIGR02168
    Location:453 → 1095
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam18615
    Location:1 → 376
    SMYLE_N; Short myomegalin-like EB1 binding proteins, N-terminal domain

  33. NM_001395316.1 → NP_001382245.1  myomegalin isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (1) summary
    TIGR02168
    Location:140 → 816
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  34. NM_001395317.1 → NP_001382246.1  myomegalin isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (2) summary
    PRK02224
    Location:611 → 1088
    PRK02224; DNA double-strand break repair Rad50 ATPase
    TIGR02168
    Location:140 → 816
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  35. NM_001395318.1 → NP_001382247.1  myomegalin isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (1) summary
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  36. NM_001395319.1 → NP_001382248.1  myomegalin isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (1) summary
    TIGR02168
    Location:53 → 729
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  37. NM_001395320.1 → NP_001382249.1  myomegalin isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (1) summary
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  38. NM_001395321.1 → NP_001382250.1  myomegalin isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (1) summary
    TIGR02168
    Location:79 → 708
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  39. NM_001395322.1 → NP_001382251.1  myomegalin isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (1) summary
    TIGR02168
    Location:18 → 647
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  40. NM_001395323.1 → NP_001382252.1  myomegalin isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC239802
    Consensus CDS
    CCDS91046.1
    UniProtKB/TrEMBL
    E9PQG4
    Related
    ENSP00000436791.1, ENST00000479408.6
    Conserved Domains (2) summary
    TIGR02168
    Location:151 → 466
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02463
    Location:28 → 724
    SMC_N; RecF/RecN/SMC N terminal domain

  41. NM_001395324.1 → NP_001382253.1  myomegalin isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC239802
    Conserved Domains (2) summary
    TIGR02168
    Location:151 → 464
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02463
    Location:28 → 722
    SMC_N; RecF/RecN/SMC N terminal domain

  42. NM_001395325.1 → NP_001382254.1  myomegalin isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    UniProtKB/TrEMBL
    A0A8Q3SI11
    Related
    ENSP00000512159.1, ENST00000695767.1
    Conserved Domains (1) summary
    COG1196
    Location:140 → 342
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  43. NM_001395326.1 → NP_001382255.1  myomegalin isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    UniProtKB/TrEMBL
    A0A8Q3SI71
    Related
    ENSP00000512161.1, ENST00000695769.1
    Conserved Domains (1) summary
    COG1196
    Location:67 → 271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  44. NM_001395327.1 → NP_001382256.1  myomegalin isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    UniProtKB/TrEMBL
    A0A8Q3SI71
    Conserved Domains (1) summary
    COG4942
    Location:57 → 234
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

  45. NM_001395328.1 → NP_001382257.1  myomegalin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389

  46. NM_001395329.1 → NP_001382258.1  myomegalin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Conserved Domains (2) summary
    PRK12704
    Location:2 → 113
    PRK12704; phosphodiesterase; Provisional
    pfam07989
    Location:1 → 41
    Cnn_1N; Centrosomin N-terminal motif 1

  47. NM_001395426.1 → NP_001382355.1  myomegalin isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804, AC245389
    Consensus CDS
    CCDS91043.1
    UniProtKB/TrEMBL
    A0A087WX83, A0A8Q3SI83
    Related
    ENSP00000512175.1, ENST00000695795.1
    Conserved Domains (2) summary
    COG1196
    Location:1910 → 2132
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:69 → 745
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  48. NM_014644.7 → NP_055459.5  myomegalin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC239804
    Consensus CDS
    CCDS72891.1
    UniProtKB/Swiss-Prot
    A0A0A0MRM0, A0A0C4DFQ0, A2RU15, E9PL24, O75042, O75065, Q2YDC1, Q5VU42, Q5VU43, Q5VU44, Q5VU45, Q5VU46, Q5VU47, Q5VU48, Q5VU49, Q68DU2, Q6AZ93, Q6PK88, Q86T40, Q86TB2, Q8N3W0, Q8TAY9, Q9HCP2, Q9HCP3, Q9HCP4, Q9HCP5
    UniProtKB/TrEMBL
    A0A087WX83
    Related
    ENSP00000358360.3, ENST00000369354.7
    Conserved Domains (2) summary
    pfam06758
    Location:1556 → 1623
    DUF1220; Repeat of unknown function (DUF1220)
    cl25732
    Location:5 → 679
    SMC_N; RecF/RecN/SMC N terminal domain

  49. NM_022359.8 → NP_071754.3  myomegalin isoform 3

    See identical proteins and their annotated locations for NP_071754.3

    Status: REVIEWED

    Source sequence(s)
    AC239802, AC245389
    Consensus CDS
    CCDS72887.1
    UniProtKB/TrEMBL
    A0A8Q3SI11
    Related
    ENSP00000482121.1, ENST00000530472.5
    Conserved Domains (2) summary
    pfam07989
    Location:143 → 210
    Cnn_1N; Centrosomin N-terminal motif 1
    cl09111
    Location:187 → 304
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    148808434..149033016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    145475230..145700086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VU43.3 GenPept UniProtKB/Swiss-Prot:Q5VU43

Gene LinkOut

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