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MDC1 mediator of DNA damage checkpoint 1 [ Homo sapiens (human) ]

Gene ID: 9656, updated on 11-Apr-2024

Summary

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Official Symbol
MDC1provided by HGNC
Official Full Name
mediator of DNA damage checkpoint 1provided by HGNC
Primary source
HGNC:HGNC:21163
See related
Ensembl:ENSG00000137337 MIM:607593; AllianceGenome:HGNC:21163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NFBD1
Summary
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 20.6), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p21.33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30699807..30717281, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30564011..30584416, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30667584..30685058, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene nurim Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30668297-30668798 Neighboring gene ribosomal protein L7 pseudogene 4 Neighboring gene MDC1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30683707-30684454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30685203-30685950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30687755-30688653 Neighboring gene tubulin beta class I Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30698119-30698743 Neighboring gene flotillin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30709349-30710229

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MDC1 maintains active elongation complexes of RNA polymerase II. Pappas G, et al. Cell Rep, 2023 Jan 31. PMID 36640322
  2. Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair. Liang Y, et al. Med Oncol, 2022 Sep 29. PMID 36175703
  3. Functional defects of cancer-associated MDC1 mutations in DNA damage repair. Xie R, et al. DNA Repair (Amst), 2022 Jun. PMID 35378404
  4. Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study. Nishi K, et al. Sci Rep, 2021 Jul 28. PMID 34321534, Free PMC Article
  5. Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast. Sottnik JL, et al. Mol Cancer Res, 2021 Aug. PMID 33947745, Free PMC Article

See all (238) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
    Title: Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
  2. A positive feedback loop between ID3 and PPARgamma via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer.
    Title: A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer.
  3. MDC1 maintains active elongation complexes of RNA polymerase II.
    Title: MDC1 maintains active elongation complexes of RNA polymerase II.
  4. Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair.
    Title: Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair.
  5. Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci.
    Title: Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci.
  6. Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
    Title: Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
  7. Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast.
    Title: Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast.
  8. Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study.
    Title: Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study.
  9. MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
    Title: MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
  10. MDC1 plays a role in tumorigenesis of oral squamous cell carcinoma
    Title: Effect of silencing of mediator of DNA damage checkpoint protein 1 on the growth of oral squamous cell carcinoma in vitro and in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0170, MGC166888, DKFZp781A0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin-protein adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of DNA damage checkpoint protein 1
Names
homologue to Drosophila photoreceptor protein calphotin
nuclear factor with BRCT domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014641.3 → NP_055456.2  mediator of DNA damage checkpoint protein 1

    See identical proteins and their annotated locations for NP_055456.2

    Status: REVIEWED

    Source sequence(s)
    AL662797, BU621433, D79992, EF177823
    Consensus CDS
    CCDS34384.1
    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBB2, A0A1U9XBC1
    Related
    ENSP00000365588.3, ENST00000376406.8
    Conserved Domains (5) summary
    pfam00498
    Location:55 → 110
    FHA; FHA domain
    cl00038
    Location:1882 → 1968
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl25732
    Location:822 → 962
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:943 → 1376
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:1227 → 1757
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30699807..30717281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419589.1 → XP_047275545.1  mediator of DNA damage checkpoint protein 1 isoform X11

  2. XM_047419588.1 → XP_047275544.1  mediator of DNA damage checkpoint protein 1 isoform X10

  3. XM_047419586.1 → XP_047275542.1  mediator of DNA damage checkpoint protein 1 isoform X7

  4. XM_005249494.6 → XP_005249551.1  mediator of DNA damage checkpoint protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005249551.1

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBB2, A0A1U9XBC1
    Conserved Domains (5) summary
    pfam00498
    Location:55 → 110
    FHA; FHA domain
    cl00038
    Location:1882 → 1968
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl25732
    Location:822 → 962
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:943 → 1376
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:1227 → 1757
    Atrophin-1; Atrophin-1 family

  5. XM_047419582.1 → XP_047275538.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_047419584.1 → XP_047275540.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  7. XM_017011522.3 → XP_016867011.1  mediator of DNA damage checkpoint protein 1 isoform X9

    UniProtKB/TrEMBL
    B4DYH4

  8. XM_047419585.1 → XP_047275541.1  mediator of DNA damage checkpoint protein 1 isoform X6

  9. XM_047419581.1 → XP_047275537.1  mediator of DNA damage checkpoint protein 1 isoform X2

  10. XM_047419587.1 → XP_047275543.1  mediator of DNA damage checkpoint protein 1 isoform X8

  11. XM_047419580.1 → XP_047275536.1  mediator of DNA damage checkpoint protein 1 isoform X1

  12. XM_047419583.1 → XP_047275539.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  13. XM_011515003.4 → XP_011513305.1  mediator of DNA damage checkpoint protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011513305.1

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBB2, A0A1U9XBC1
    Conserved Domains (5) summary
    pfam00498
    Location:55 → 110
    FHA; FHA domain
    cl00038
    Location:1882 → 1968
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl25732
    Location:822 → 962
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:943 → 1376
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:1227 → 1757
    Atrophin-1; Atrophin-1 family

  14. XM_005249498.5 → XP_005249555.1  mediator of DNA damage checkpoint protein 1 isoform X8

    See identical proteins and their annotated locations for XP_005249555.1

    UniProtKB/TrEMBL
    B4DYH4
    Conserved Domains (2) summary
    cd00027
    Location:1663 → 1715
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00498
    Location:76 → 144
    FHA; FHA domain

  15. XM_005249497.5 → XP_005249554.1  mediator of DNA damage checkpoint protein 1 isoform X5

    See identical proteins and their annotated locations for XP_005249554.1

    UniProtKB/TrEMBL
    A0A1U9XBB2
    Conserved Domains (2) summary
    cd00027
    Location:1737 → 1789
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00498
    Location:76 → 144
    FHA; FHA domain

  16. XM_005249492.3 → XP_005249549.1  mediator of DNA damage checkpoint protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005249549.1

    UniProtKB/TrEMBL
    A0A1U9XBB2
    Conserved Domains (6) summary
    PTZ00449
    Location:964 → 1397
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:1248 → 1778
    PHA03247; large tegument protein UL36; Provisional
    cd00060
    Location:54 → 144
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02169
    Location:843 → 983
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd17744
    Location:1914 → 1984
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:2016 → 2096
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins

  17. XM_011515004.4 → XP_011513306.1  mediator of DNA damage checkpoint protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011513306.1

    UniProtKB/TrEMBL
    A0A1U9XBB2
    Conserved Domains (1) summary
    cd00027
    Location:1778 → 1830
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2029312..2047039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328530.1 → XP_054184505.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  2. XM_054328540.1 → XP_054184515.1  mediator of DNA damage checkpoint protein 1 isoform X11

  3. XM_054328539.1 → XP_054184514.1  mediator of DNA damage checkpoint protein 1 isoform X10

  4. XM_054328531.1 → XP_054184506.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  5. XM_054328533.1 → XP_054184508.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_054328538.1 → XP_054184513.1  mediator of DNA damage checkpoint protein 1 isoform X9

  7. XM_054328536.1 → XP_054184511.1  mediator of DNA damage checkpoint protein 1 isoform X6

  8. XM_054328529.1 → XP_054184504.1  mediator of DNA damage checkpoint protein 1 isoform X2

  9. XM_054328537.1 → XP_054184512.1  mediator of DNA damage checkpoint protein 1 isoform X8

  10. XM_054328535.1 → XP_054184510.1  mediator of DNA damage checkpoint protein 1 isoform X5

  11. XM_054328527.1 → XP_054184502.1  mediator of DNA damage checkpoint protein 1 isoform X1

  12. XM_054328532.1 → XP_054184507.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  13. XM_054328528.1 → XP_054184503.1  mediator of DNA damage checkpoint protein 1 isoform X1

  14. XM_054328534.1 → XP_054184509.1  mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2179547..2198636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329934.1 → XP_054185909.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  2. XM_054329941.1 → XP_054185916.1  mediator of DNA damage checkpoint protein 1 isoform X7

  3. XM_054329946.1 → XP_054185921.1  mediator of DNA damage checkpoint protein 1 isoform X11

  4. XM_054329945.1 → XP_054185920.1  mediator of DNA damage checkpoint protein 1 isoform X10

  5. XM_054329935.1 → XP_054185910.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_054329937.1 → XP_054185912.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  7. XM_054329944.1 → XP_054185919.1  mediator of DNA damage checkpoint protein 1 isoform X9

  8. XM_054329940.1 → XP_054185915.1  mediator of DNA damage checkpoint protein 1 isoform X6

  9. XM_054329933.1 → XP_054185908.1  mediator of DNA damage checkpoint protein 1 isoform X2

  10. XM_054329942.1 → XP_054185917.1  mediator of DNA damage checkpoint protein 1 isoform X8

  11. XM_054329939.1 → XP_054185914.1  mediator of DNA damage checkpoint protein 1 isoform X5

  12. XM_054329931.1 → XP_054185906.1  mediator of DNA damage checkpoint protein 1 isoform X1

  13. XM_054329943.1 → XP_054185918.1  mediator of DNA damage checkpoint protein 1 isoform X8

  14. XM_054329936.1 → XP_054185911.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  15. XM_054329932.1 → XP_054185907.1  mediator of DNA damage checkpoint protein 1 isoform X1

  16. XM_054329938.1 → XP_054185913.1  mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1955659..1974752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330428.1 → XP_054186403.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  2. XM_054330439.1 → XP_054186414.1  mediator of DNA damage checkpoint protein 1 isoform X11

  3. XM_054330438.1 → XP_054186413.1  mediator of DNA damage checkpoint protein 1 isoform X10

  4. XM_054330429.1 → XP_054186404.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  5. XM_054330431.1 → XP_054186406.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_054330437.1 → XP_054186412.1  mediator of DNA damage checkpoint protein 1 isoform X9

  7. XM_054330434.1 → XP_054186409.1  mediator of DNA damage checkpoint protein 1 isoform X6

  8. XM_054330426.1 → XP_054186401.1  mediator of DNA damage checkpoint protein 1 isoform X2

  9. XM_054330435.1 → XP_054186410.1  mediator of DNA damage checkpoint protein 1 isoform X8

  10. XM_054330433.1 → XP_054186408.1  mediator of DNA damage checkpoint protein 1 isoform X5

  11. XM_054330424.1 → XP_054186399.1  mediator of DNA damage checkpoint protein 1 isoform X1

  12. XM_054330427.1 → XP_054186402.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  13. XM_054330430.1 → XP_054186405.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  14. XM_054330425.1 → XP_054186400.1  mediator of DNA damage checkpoint protein 1 isoform X1

  15. XM_054330436.1 → XP_054186411.1  mediator of DNA damage checkpoint protein 1 isoform X8

  16. XM_054330432.1 → XP_054186407.1  mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    2010059..2030465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330696.1 → XP_054186671.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  2. XM_054330702.1 → XP_054186677.1  mediator of DNA damage checkpoint protein 1 isoform X7

  3. XM_054330704.1 → XP_054186679.1  mediator of DNA damage checkpoint protein 1 isoform X11

  4. XM_054330703.1 → XP_054186678.1  mediator of DNA damage checkpoint protein 1 isoform X10

  5. XM_054330697.1 → XP_054186672.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_054330699.1 → XP_054186674.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  7. XM_054330698.1 → XP_054186673.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  8. XM_054330701.1 → XP_054186676.1  mediator of DNA damage checkpoint protein 1 isoform X13

  9. XM_054330695.1 → XP_054186670.1  mediator of DNA damage checkpoint protein 1 isoform X12

  10. XM_054330700.1 → XP_054186675.1  mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    2043883..2064289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330922.1 → XP_054186897.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  2. XM_054330928.1 → XP_054186903.1  mediator of DNA damage checkpoint protein 1 isoform X7

  3. XM_054330933.1 → XP_054186908.1  mediator of DNA damage checkpoint protein 1 isoform X11

  4. XM_054330932.1 → XP_054186907.1  mediator of DNA damage checkpoint protein 1 isoform X10

  5. XM_054330921.1 → XP_054186896.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_054330924.1 → XP_054186899.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  7. XM_054330931.1 → XP_054186906.1  mediator of DNA damage checkpoint protein 1 isoform X9

  8. XM_054330927.1 → XP_054186902.1  mediator of DNA damage checkpoint protein 1 isoform X6

  9. XM_054330919.1 → XP_054186894.1  mediator of DNA damage checkpoint protein 1 isoform X2

  10. XM_054330929.1 → XP_054186904.1  mediator of DNA damage checkpoint protein 1 isoform X8

  11. XM_054330926.1 → XP_054186901.1  mediator of DNA damage checkpoint protein 1 isoform X5

  12. XM_054330917.1 → XP_054186892.1  mediator of DNA damage checkpoint protein 1 isoform X1

  13. XM_054330930.1 → XP_054186905.1  mediator of DNA damage checkpoint protein 1 isoform X8

  14. XM_054330920.1 → XP_054186895.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  15. XM_054330923.1 → XP_054186898.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  16. XM_054330918.1 → XP_054186893.1  mediator of DNA damage checkpoint protein 1 isoform X1

  17. XM_054330925.1 → XP_054186900.1  mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1954920..1972647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331201.1 → XP_054187176.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBE3

  2. XM_054331208.1 → XP_054187183.1  mediator of DNA damage checkpoint protein 1 isoform X7

  3. XM_054331212.1 → XP_054187187.1  mediator of DNA damage checkpoint protein 1 isoform X11

  4. XM_054331211.1 → XP_054187186.1  mediator of DNA damage checkpoint protein 1 isoform X10

  5. XM_054331202.1 → XP_054187177.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBE3

  6. XM_054331204.1 → XP_054187179.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBE3

  7. XM_054331210.1 → XP_054187185.1  mediator of DNA damage checkpoint protein 1 isoform X9

  8. XM_054331209.1 → XP_054187184.1  mediator of DNA damage checkpoint protein 1 isoform X8

  9. XM_054331198.1 → XP_054187173.1  mediator of DNA damage checkpoint protein 1 isoform X1

  10. XM_054331203.1 → XP_054187178.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBE3

  11. XM_054331200.1 → XP_054187175.1  mediator of DNA damage checkpoint protein 1 isoform X2

  12. XM_054331199.1 → XP_054187174.1  mediator of DNA damage checkpoint protein 1 isoform X1

  13. XM_054331207.1 → XP_054187182.1  mediator of DNA damage checkpoint protein 1 isoform X6

  14. XM_054331206.1 → XP_054187181.1  mediator of DNA damage checkpoint protein 1 isoform X5

  15. XM_054331205.1 → XP_054187180.1  mediator of DNA damage checkpoint protein 1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    2000593..2019687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331438.1 → XP_054187413.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBF2

  2. XM_054331439.1 → XP_054187414.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBF2

  3. XM_054331447.1 → XP_054187422.1  mediator of DNA damage checkpoint protein 1 isoform X9

  4. XM_054331444.1 → XP_054187419.1  mediator of DNA damage checkpoint protein 1 isoform X6

  5. XM_054331437.1 → XP_054187412.1  mediator of DNA damage checkpoint protein 1 isoform X2

  6. XM_054331445.1 → XP_054187420.1  mediator of DNA damage checkpoint protein 1 isoform X8

  7. XM_054331443.1 → XP_054187418.1  mediator of DNA damage checkpoint protein 1 isoform X5

  8. XM_054331436.1 → XP_054187411.1  mediator of DNA damage checkpoint protein 1 isoform X1

  9. XM_054331440.1 → XP_054187415.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBF2

  10. XM_054331446.1 → XP_054187421.1  mediator of DNA damage checkpoint protein 1 isoform X8

  11. XM_054331441.1 → XP_054187416.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1U9XBF2

  12. XM_054331442.1 → XP_054187417.1  mediator of DNA damage checkpoint protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30564011..30584416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356869.1 → XP_054212844.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  2. XM_054356875.1 → XP_054212850.1  mediator of DNA damage checkpoint protein 1 isoform X7

  3. XM_054356880.1 → XP_054212855.1  mediator of DNA damage checkpoint protein 1 isoform X11

  4. XM_054356879.1 → XP_054212854.1  mediator of DNA damage checkpoint protein 1 isoform X10

  5. XM_054356868.1 → XP_054212843.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  6. XM_054356871.1 → XP_054212846.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  7. XM_054356878.1 → XP_054212853.1  mediator of DNA damage checkpoint protein 1 isoform X9

  8. XM_054356874.1 → XP_054212849.1  mediator of DNA damage checkpoint protein 1 isoform X6

  9. XM_054356867.1 → XP_054212842.1  mediator of DNA damage checkpoint protein 1 isoform X2

  10. XM_054356876.1 → XP_054212851.1  mediator of DNA damage checkpoint protein 1 isoform X8

  11. XM_054356873.1 → XP_054212848.1  mediator of DNA damage checkpoint protein 1 isoform X5

  12. XM_054356865.1 → XP_054212840.1  mediator of DNA damage checkpoint protein 1 isoform X1

  13. XM_054356877.1 → XP_054212852.1  mediator of DNA damage checkpoint protein 1 isoform X8

  14. XM_054356870.1 → XP_054212845.1  mediator of DNA damage checkpoint protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q14676, Q2L6H7, Q2TAZ4, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2
    UniProtKB/TrEMBL
    A0A1U9XBC1

  15. XM_054356866.1 → XP_054212841.1  mediator of DNA damage checkpoint protein 1 isoform X1

  16. XM_054356872.1 → XP_054212847.1  mediator of DNA damage checkpoint protein 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14676.3 GenPept UniProtKB/Swiss-Prot:Q14676

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