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MORF4L2 mortality factor 4 like 2 [ Homo sapiens (human) ]

Gene ID: 9643, updated on 5-Mar-2024

Summary

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Official Symbol
MORF4L2provided by HGNC
Official Full Name
mortality factor 4 like 2provided by HGNC
Primary source
HGNC:HGNC:16849
See related
Ensembl:ENSG00000123562 MIM:300409; AllianceGenome:HGNC:16849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRGX; MORFL2
Summary
Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleolus; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 110.4), endometrium (RPKM 100.8) and 25 other tissues See more
Orthologs
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Genomic context

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See MORF4L2 in Genome Data Viewer
Location:
Xq22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103675498..103688047, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102122473..102135021, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102930426..102942975, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1 Neighboring gene MORF4L2 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102951966-102952716 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102952717-102953467 Neighboring gene glycine receptor alpha 4 (pseudogene) Neighboring gene transmembrane protein 31 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102985791-102986664 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102996691-102997226 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102997227-102997764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:103009420-103009920 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103020819-103021470 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:103022123-103022774 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene proteolipid protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2. Kooblall KG, et al. Endocr Relat Cancer, 2022 Oct 1. PMID 35900839, Free PMC Article
  2. Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X. Sakai K, et al. Mol Cell Neurosci, 2002 Apr. PMID 11988016
  3. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics. Zhang R, et al. Life Sci, 2020 Dec 1. PMID 33011223
  4. Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment. Kuo WY, et al. Oncotarget, 2015 Apr 20. PMID 25796627, Free PMC Article
  5. Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Pezo RC, et al. Cancer Res, 2008 Jul 1. PMID 18593893, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2.
    Title: miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2.
  2. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics.
    Title: Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics.
  3. Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as MORF4L2 in lung cancer cells remaining after treatment, creating a more drug-resistant state.
    Title: Enhancement of tumor initiation and expression of KCNMA1, MORF4L2 and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment.
  4. The transcriptional status of four key genes, thymidylate synthase (TYMS), MORF-related gene X (MRGX), Bcl2-antagonist/killer (BAK), and ATPase, Cu(2+) transporting beta polypeptide (ATP7B), can accurately predict response to 5-FU.
    Title: Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors.
  5. can repress or activate the B-myb promoter depending on the cell type studied, suggesting that there may be tissue-specific functions of this protein
    Title: MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0026

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
mortality factor 4-like protein 2
Names
MORF-related gene X protein
MSL3-2 protein
protein MSL3-2
transcription factor-like protein MRGX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142418.2 → NP_001135890.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC093013, DC419967
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  2. NM_001142419.2 → NP_001135891.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA268606
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Related
    ENSP00000415476.2, ENST00000433176.6
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  3. NM_001142420.2 → NP_001135892.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  4. NM_001142421.2 → NP_001135893.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA268606
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Related
    ENSP00000353643.1, ENST00000360458.5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  5. NM_001142422.2 → NP_001135894.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA268606
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  6. NM_001142423.2 → NP_001135895.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  7. NM_001142424.2 → NP_001135896.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  8. NM_001142425.2 → NP_001135897.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  9. NM_001142426.2 → NP_001135898.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Related
    ENSP00000410532.1, ENST00000451301.5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  10. NM_001142427.2 → NP_001135899.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, BM835303
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  11. NM_001142428.2 → NP_001135900.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DA068448
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  12. NM_001142429.2 → NP_001135901.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DC301727
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  13. NM_001142430.2 → NP_001135902.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, BM471743, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  14. NM_001142431.2 → NP_001135903.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DA268606, DC366195
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  15. NM_001142432.2 → NP_001135904.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DC424668
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

  16. NM_012286.3 → NP_036418.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_036418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    B3KP92, D3DXA5, Q15014, Q567V0, Q8J026
    UniProtKB/TrEMBL
    B3KX14, Q53EY5
    Related
    ENSP00000391969.2, ENST00000441076.7
    Conserved Domains (1) summary
    pfam05712
    Location:110 → 276
    MRG

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103675498..103688047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102122473..102135021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15014.1 GenPept UniProtKB/Swiss-Prot:Q15014

Gene LinkOut

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