U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EI24 EI24 autophagy associated transmembrane protein [ Homo sapiens (human) ]

Gene ID: 9538, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
EI24provided by HGNC
Official Full Name
EI24 autophagy associated transmembrane proteinprovided by HGNC
Primary source
HGNC:HGNC:13276
See related
Ensembl:ENSG00000149547 MIM:605170; AllianceGenome:HGNC:13276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPG4; PIG8; TP53I8
Summary
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in liver (RPKM 39.6), colon (RPKM 30.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See EI24 in Genome Data Viewer
Location:
11q24.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125569477..125584684)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125598125..125613333)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125439373..125454579)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PBX/knotted 1 homeobox 2 Neighboring gene RNA, U6 small nuclear 321, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125181994-125182578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125211245-125211994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125219321-125219863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125220519-125221182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125221183-125221844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125239164-125240045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125241808-125242687 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:125278650-125279849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125296399-125296900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125298605-125299508 Neighboring gene Sharpr-MPRA regulatory region 8813 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125314964-125315827 Neighboring gene Sharpr-MPRA regulatory region 13231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:125364213-125364716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125365219-125365722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125365723-125366224 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene putative uncharacterized protein MGC39545 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5907 Neighboring gene Sharpr-MPRA regulatory region 4861 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5909 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125439037-125439538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5698 Neighboring gene STT3A antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1156, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5699 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125462019-125462613 Neighboring gene uncharacterized LOC118567325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5700 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene checkpoint kinase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Integrated analysis of the prognostic value of TP53 dependent etoposide-induced gene 24 in non-small cell lung cancer. Wang M, et al. Biomed Pharmacother, 2019 Apr. PMID 30784913
  2. Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases. Devkota S, et al. Autophagy, 2016 Nov. PMID 27541728, Free PMC Article
  3. Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis. Gentile M, et al. Oncogene, 2001 Nov 22. PMID 11753653
  4. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Burns TF, et al. Oncogene, 2001 Aug 2. PMID 11498783
  5. miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24. Zhou W, et al. Mol Med Rep, 2021 Aug. PMID 34109432

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR483 promotes the development of colorectal cancer by inhibiting the expression level of EI24.
    Title: miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24.
  2. EI24 is a prognostic biomarker and impacts poor outcome in non-small cell lung cancer.
    Title: Integrated analysis of the prognostic value of TP53 dependent etoposide-induced gene 24 in non-small cell lung cancer.
  3. EI24 is an essential player in ubiquitin-proteasome system-autophagy crosstalk via degradation of RING E3 ligases.
    Title: Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases.
  4. Low EI24 expression is associated with triple negative breast cancer.
    Title: MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24.
  5. Low EI24 and high IGF-1R expressions in lung cancer patients.
    Title: Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells.
  6. Findings establish EI24 as a critical suppressor of tumor progression.
    Title: EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.
  7. Ei24 can bind specifically to IMPbeta1 and IMPalpha2 to impede their normal role in nuclear import.
    Title: The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.
  8. Ei24 is a novel E2F1 target gene contributing to the survival of p53-deficient cells upon UVC irradiation and thus may have a potential significance as a therapeutic target of certain chemotherapy for treating p53-deficient tumors.
    Title: Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.
  9. our data suggest that inactivation of EI24 and CHEK1 through two independent mechanisms contributes to the development of CACX.
    Title: Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: clinical and prognostic implications.
  10. LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance.
    Title: Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1-24.2 region in breast carcinoma: clinical and prognostic implications.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables importin-alpha family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
etoposide-induced protein 2.4 homolog
Names
ectopic P-granules autophagy protein 4 homolog
etoposide induced 2.4
p53-induced gene 8 protein
tumor protein p53 inducible protein 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032933.1 RefSeqGene

    Range
    5076..20283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290135.2 → NP_001277064.1  etoposide-induced protein 2.4 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK296620, BC002390, BG566671, DA680745, DB520736
    Consensus CDS
    CCDS76493.1
    UniProtKB/Swiss-Prot
    O14681
    Related
    ENSP00000479943.1, ENST00000534546.5
    Conserved Domains (1) summary
    pfam07264
    Location:106 → 240
    EI24; Etoposide-induced protein 2.4 (EI24)

  2. NM_001330419.2 → NP_001317348.1  etoposide-induced protein 2.4 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate exon in the 3' coding region that results in a frame-shift compared to variant 1. The encoded isoform (4) is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA313725, AP001494, BF770607, DA680745, HY010870, KF459674
    Consensus CDS
    CCDS81643.1
    UniProtKB/TrEMBL
    E9PK61

  3. NM_004879.5 → NP_004870.3  etoposide-induced protein 2.4 homolog isoform 1

    See identical proteins and their annotated locations for NP_004870.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC002390, BG566671, DA680745, DB520736
    Consensus CDS
    CCDS73410.1
    UniProtKB/Swiss-Prot
    A8K7D6, B4DKL6, O14681, Q9BUQ1
    Related
    ENSP00000278903.7, ENST00000278903.11
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 254
    EI24; Etoposide-induced protein 2.4 (EI24)

RNA

  1. NR_110769.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AB209820, AK301556, BG566671, DA680745, DB520736, DB567734

  2. NR_110770.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AB209820, AK316539, BG566671, DA680745, DB520736, DB567734

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    125569477..125584684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543069.3 → XP_011541371.1  etoposide-induced protein 2.4 homolog isoform X1

    See identical proteins and their annotated locations for XP_011541371.1

    UniProtKB/Swiss-Prot
    A8K7D6, B4DKL6, O14681, Q9BUQ1
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 254
    EI24; Etoposide-induced protein 2.4 (EI24)

  2. XM_011543070.2 → XP_011541372.1  etoposide-induced protein 2.4 homolog isoform X2

    UniProtKB/TrEMBL
    E9PK61
    Related
    ENSP00000431633.3, ENST00000527235.6
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 222
    EI24; Etoposide-induced protein 2.4 (EI24)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    125598125..125613333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370557.1 → XP_054226532.1  etoposide-induced protein 2.4 homolog isoform X1

    UniProtKB/Swiss-Prot
    A8K7D6, B4DKL6, O14681, Q9BUQ1

  2. XM_054370558.1 → XP_054226533.1  etoposide-induced protein 2.4 homolog isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007277.1: Suppressed sequence

    Description
    NM_001007277.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14681.4 GenPept UniProtKB/Swiss-Prot:O14681

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous