U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BAG4 BAG cochaperone 4 [ Homo sapiens (human) ]

Gene ID: 9530, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
BAG4provided by HGNC
Official Full Name
BAG cochaperone 4provided by HGNC
Primary source
HGNC:HGNC:940
See related
Ensembl:ENSG00000156735 MIM:603884; AllianceGenome:HGNC:940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SODD; BAG-4
Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in brain (RPKM 11.2), bone marrow (RPKM 7.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8p11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38176855..38213301)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38453834..38490242)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38034373..38070819)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379382 Neighboring gene RNA, U6 small nuclear 323, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38032979-38033836 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38033837-38034694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27245 Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27246 Neighboring gene Sharpr-MPRA regulatory region 4585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19117 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38089405-38089904 Neighboring gene DDHD domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19119 Neighboring gene phospholipid phosphatase 5 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19120 Neighboring gene NUP98-NSD3 recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27247 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38235530-38236031 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38238312-38238846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38239137-38239927

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells. Yi L, et al. Mol Med Rep, 2017 Oct. PMID 29067445, Free PMC Article
  2. Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett's Associated Esophageal Adenocarcinoma Cells. Li D, et al. J Pharmacol Exp Ther, 2017 Jan. PMID 27756772, Free PMC Article
  3. Significance of SODD expression in childhood acute lymphoblastic leukemia and its influence on chemotherapy. Tao HF, et al. Genet Mol Res, 2014 Mar 24. PMID 24737427
  4. [Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs]. Tao HF, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007 Jun. PMID 17605853
  5. BAG4/SODD protein contains a short BAG domain. Briknarová K, et al. J Biol Chem, 2002 Aug 23. PMID 12058034

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT and RAF/MEK/ERK Signaling.
    Title: SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT and RAF/MEK/ERK Signaling.
  2. Bcl2-associated athanogene 4 promotes the invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-kappaB/ZEB1 axis.
    Title: Bcl2-associated athanogene 4 promotes the invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-κB/ZEB1 axis.
  3. AGS cells overexpressing BAG4 exhibited a significant increase in the percentage of cells in the G1/G0 peak and transfection of shRNA decrese demonstrated the opposite effect.
    Title: Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells.
  4. acid-induced increase in SODD expression and decrease in cell apoptosis may depend on the activation of NOX5-S and NF-kappaB1 p50 in FLO cells
    Title: Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett's Associated Esophageal Adenocarcinoma Cells.
  5. SODD over-expression might be correlated with the clinical classification, curative effect, and prognosis of ALL cells.
    Title: Significance of SODD expression in childhood acute lymphoblastic leukemia and its influence on chemotherapy.
  6. MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD).
    Title: MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD).
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
  9. Vincristine induces Jurkat cell apoptosis by downregulating expression of SODD protein and priming the death receptor pathway.
    Title: [Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs].
  10. BAG-4 functions as a negative regulator for apobec-1-mediated apoB mRNA editing
    Title: Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp586O2022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of mRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
BAG family molecular chaperone regulator 4
Names
BCL2 associated athanogene 4
bcl-2-associated athanogene 4
silencer of death domains

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204878.2 → NP_001191807.1  BAG family molecular chaperone regulator 4 isoform 2

    See identical proteins and their annotated locations for NP_001191807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC084024, BC000800, BM683128
    Consensus CDS
    CCDS56533.1
    UniProtKB/TrEMBL
    B2RA34
    Related
    ENSP00000393298.2, ENST00000432471.6
    Conserved Domains (2) summary
    smart00264
    Location:343 → 420
    BAG; BAG domains, present in regulator of Hsp70 proteins
    pfam15822
    Location:80 → 231
    MISS; MAPK-interacting and spindle-stabilizing protein-like

  2. NM_004874.4 → NP_004865.1  BAG family molecular chaperone regulator 4 isoform 1

    See identical proteins and their annotated locations for NP_004865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC084024, AF095194, BM683128
    Consensus CDS
    CCDS6104.1
    UniProtKB/Swiss-Prot
    B4E217, O95429, O95818
    UniProtKB/TrEMBL
    B2RA34
    Related
    ENSP00000287322.4, ENST00000287322.5
    Conserved Domains (1) summary
    smart00264
    Location:379 → 456
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38176855..38213301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    38453834..38490242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95429.1 GenPept UniProtKB/Swiss-Prot:O95429

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous