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GNG8 G protein subunit gamma 8 [ Homo sapiens (human) ]

Gene ID: 94235, updated on 5-Mar-2024

Summary

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Official Symbol
GNG8provided by HGNC
Official Full Name
G protein subunit gamma 8provided by HGNC
Primary source
HGNC:HGNC:19664
See related
Ensembl:ENSG00000167414 AllianceGenome:HGNC:19664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3E
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
19q13.32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46633953..46639326, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49459562..49464865, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47137210..47139459, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904729 Neighboring gene calmodulin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47119779-47120280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47120281-47120780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47124126-47124640 Neighboring gene prostaglandin I2 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47128561-47129061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10816 Neighboring gene Sharpr-MPRA regulatory region 2120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47157789-47158515 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10821 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. Hurowitz EH, et al. DNA Res, 2000 Apr 28. PMID 10819326
  2. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. El-Haibi CP, et al. Mol Cancer, 2013 Jun 18. PMID 23773523, Free PMC Article
  3. The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. Sun Z, et al. Cell Signal, 2012 Dec. PMID 22940628, Free PMC Article
  4. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. Rosskopf D, et al. FEBS Lett, 2003 Jun 5. PMID 12782285
  5. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Krishnan A, et al. Mol Phylogenet Evol, 2015 Oct. PMID 26002831

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular response to pheromone IEA
Inferred from Electronic Annotation
more info
  
involved_in nose development IEA
Inferred from Electronic Annotation
more info
  
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Names
gamma-9
guanine nucleotide binding protein (G protein), gamma 8
heterotrimeric guanine nucleotide-binding protein 3E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033258.2 → NP_150283.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    See identical proteins and their annotated locations for NP_150283.1

    Status: VALIDATED

    Source sequence(s)
    AC093503
    Consensus CDS
    CCDS12687.1
    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08
    Related
    ENSP00000508424.1, ENST00000693335.1
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46633953..46639326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027505.1 → XP_016882994.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs

  2. XM_017027504.3 → XP_016882993.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08
    Related
    ENSP00000300873.3, ENST00000300873.5
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs

  3. XM_047439725.1 → XP_047295681.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49459562..49464865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322688.1 → XP_054178663.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08

  2. XM_054322687.1 → XP_054178662.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08

  3. XM_054322686.1 → XP_054178661.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBM5, Q9UK08
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK08.1 GenPept UniProtKB/Swiss-Prot:Q9UK08

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