SNORD27 small nucleolar RNA, C/D box 27 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SNORD27provided by HGNC
Official Full Name: small nucleolar RNA, C/D box 27provided by HGNC
Primary source: HGNC:HGNC:10149
See related: Ensembl:ENSG00000275996 MIM:603226; AllianceGenome:HGNC:10149
Gene type: snoRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: U27; RNU27
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Genomic context

Location:: 11q12.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (62855012..62855083, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (62844407..62844478, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (62622484..62622555, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

As part of a previously unidentified complex, SNORD27 regulates alternative splicing of the E2F7 pre-mRNA through direct RNA-RNA interaction without methylating the RNA, likely by competing with U1 snRNP.
Title: Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing.
Overexpression of SNORD27 is associated with high-risk smoldering multiple myeloma.
Title: Genomic analysis of high-risk smoldering multiple myeloma.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.