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SLC16A6 solute carrier family 16 member 6 [ Homo sapiens (human) ]

Gene ID: 9120, updated on 11-Apr-2024

Summary

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Official Symbol
SLC16A6provided by HGNC
Official Full Name
solute carrier family 16 member 6provided by HGNC
Primary source
HGNC:HGNC:10927
See related
Ensembl:ENSG00000108932 MIM:603880; AllianceGenome:HGNC:10927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT6; MCT7
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 4.8), appendix (RPKM 3.2) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
17q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (68267026..68291479, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (69143596..69168075, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66263167..66287268, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66196439-66197255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8895 Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66224773-66225658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8896 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:66242704-66243250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66243251-66243796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8898 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:66287460-66287634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12644 Neighboring gene arylsulfatase G Neighboring gene Sharpr-MPRA regulatory region 10227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340482-66340982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:66340983-66341483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66374359-66374878 Neighboring gene MPRA-validated peak2959 silencer Neighboring gene tRNA-undetermined (NNN) 5-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409262-66409920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:66409921-66410577 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene microRNA 635 Neighboring gene WD repeat domain, phosphoinositide interacting 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. Higuchi K, et al. J Biol Chem, 2022 Apr. PMID 35257743, Free PMC Article
  2. Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival. Dai W, et al. Mol Carcinog, 2020 Jun. PMID 32232919, Free PMC Article
  3. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). Murakami Y, et al. Drug Metab Dispos, 2005 Dec. PMID 16174808
  4. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, et al. Biochem J, 1998 Jan 15. PMID 9425115, Free PMC Article
  5. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter.
    Title: Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter.
  2. Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.
    Title: Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival.
  3. MCT6 is involved in the disposition of various drugs, including bumetanide.
    Title: Functional characterization of human monocarboxylate transporter 6 (SLC16A5).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of solute carrier family 16, member 6 (SLC16A6) in Vif-expression T cells PubMed
capsid gag Depletion of the SLC16A6 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables taurine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in taurine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 7
Names
breast cancer protein BCY5
monocarboxylate transporter 6
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174166.2 → NP_001167637.1  monocarboxylate transporter 7

    See identical proteins and their annotated locations for NP_001167637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AC005332, BC064832, U79745
    Consensus CDS
    CCDS11675.1
    UniProtKB/Swiss-Prot
    O15403, Q6P1X3
    UniProtKB/TrEMBL
    A8K302
    Related
    ENSP00000319991.4, ENST00000327268.8
    Conserved Domains (1) summary
    cd17422
    Location:24 → 472
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  2. NM_004694.5 → NP_004685.2  monocarboxylate transporter 7

    See identical proteins and their annotated locations for NP_004685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC005332, BC064832
    Consensus CDS
    CCDS11675.1
    UniProtKB/Swiss-Prot
    O15403, Q6P1X3
    UniProtKB/TrEMBL
    A8K302
    Related
    ENSP00000462985.1, ENST00000580666.6
    Conserved Domains (1) summary
    cd17422
    Location:24 → 472
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    68267026..68291479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451021.2 → XP_024306789.2  monocarboxylate transporter 7 isoform X1

  2. XM_011525461.4 → XP_011523763.1  monocarboxylate transporter 7 isoform X2

    See identical proteins and their annotated locations for XP_011523763.1

    UniProtKB/Swiss-Prot
    O15403, Q6P1X3
    UniProtKB/TrEMBL
    A8K302
    Conserved Domains (1) summary
    cd17422
    Location:24 → 472
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  3. XM_047437020.1 → XP_047292976.1  monocarboxylate transporter 7 isoform X2

    UniProtKB/Swiss-Prot
    O15403, Q6P1X3

  4. XM_017025292.3 → XP_016880781.1  monocarboxylate transporter 7 isoform X2

    UniProtKB/Swiss-Prot
    O15403, Q6P1X3
    UniProtKB/TrEMBL
    A8K302
    Conserved Domains (1) summary
    cd17422
    Location:24 → 472
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    69143596..69168075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317736.1 → XP_054173711.1  monocarboxylate transporter 7 isoform X1

  2. XM_054317737.1 → XP_054173712.1  monocarboxylate transporter 7 isoform X2

  3. XM_054317738.1 → XP_054173713.1  monocarboxylate transporter 7 isoform X2

  4. XM_054317739.1 → XP_054173714.1  monocarboxylate transporter 7 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15403.2 GenPept UniProtKB/Swiss-Prot:O15403

Gene LinkOut

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