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LATS1 large tumor suppressor kinase 1 [ Homo sapiens (human) ]

Gene ID: 9113, updated on 7-Apr-2024

Summary

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Official Symbol
LATS1provided by HGNC
Official Full Name
large tumor suppressor kinase 1provided by HGNC
Primary source
HGNC:HGNC:6514
See related
Ensembl:ENSG00000131023 MIM:603473; AllianceGenome:HGNC:6514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
wts; WARTS
Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6q25.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149658153..149718101, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150857942..150917878, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149979289..150039237, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene katanin catalytic subunit A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17664 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:150022675-150023256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17665 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:150045663-150045865 Neighboring gene uncharacterized LOC645967 Neighboring gene nucleoporin 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:150069877-150070842 Neighboring gene Sharpr-MPRA regulatory region 3985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150071808-150072310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150072311-150072813 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:150106480-150106982 Neighboring gene BTB domain containing 10 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion. Wan W, et al. Cell Mol Biol (Noisy-le-grand), 2022 May 31. PMID 36029506
  2. Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family. Geng L, et al. Neurol Sci, 2022 Nov. PMID 35986120
  3. The clinicopathological and prognostic significances of LATS1 expression in breast cancer. Zheng HC, et al. Histol Histopathol, 2022 Jul. PMID 35142365
  4. Long non-coding RNA FAM66C regulates glioma growth via the miRNA/LATS1 signaling pathway. Xiao K, et al. Biol Chem, 2022 Jun 27. PMID 34954927
  5. lncRNA TINCR attenuates the proliferation and invasion, and enhances the apoptosis of cutaneous malignant melanoma cells by regulating the miR‑424‑5p/LATS1 axis. Han X, et al. Oncol Rep, 2021 Nov. PMID 34542165, Free PMC Article

See all (215) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
    Title: LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
  2. S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
    Title: S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
  3. WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
    Title: WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
  4. DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
    Title: DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
  5. Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
    Title: Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
  6. Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.
    Title: Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.
  7. The clinicopathological and prognostic significances of LATS1 expression in breast cancer.
    Title: The clinicopathological and prognostic significances of LATS1 expression in breast cancer.
  8. TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein.
    Title: TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein.
  9. Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion.
    Title: Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion.
  10. LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
    Title: LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (118)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic sequestering of protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hippo signaling TAS
Traceable Author Statement
more info
  
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inner cell mass cell fate commitment IEA
Inferred from Electronic Annotation
more info
  
involved_in inner cell mass cellular morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mammary gland epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid segregation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase LATS1
Names
LATS (large tumor suppressor, Drosophila) homolog 1
LATS, large tumor suppressor, homolog 1
WARTS protein kinase
h-warts
large tumor suppressor homolog 1
NP_001257448.1
NP_001337268.1
NP_001337269.1
NP_001337321.1
NP_004681.1
XP_006715666.1
XP_011534554.1
XP_016866963.1
XP_016866966.1
XP_016866968.1
XP_024302351.1
XP_047275473.1
XP_047275474.1
XP_047275475.1
XP_047275477.1
XP_047275478.1
XP_054212719.1
XP_054212720.1
XP_054212721.1
XP_054212722.1
XP_054212723.1
XP_054212724.1
XP_054212725.1
XP_054212726.1
XP_054212727.1
XP_054212728.1
XP_054212729.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270519.2 → NP_001257448.1  serine/threonine-protein kinase LATS1 isoform 2

    See identical proteins and their annotated locations for NP_001257448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF104413, AL358852, AL583963, BC002767
    Consensus CDS
    CCDS59040.1
    UniProtKB/Swiss-Prot
    O95835
    Related
    ENSP00000444678.1, ENST00000392273.7
    Conserved Domains (3) summary
    cd14397
    Location:103 → 143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl26247
    Location:473 → 558
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl28087
    Location:467 → 673
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001350339.2 → NP_001337268.1  serine/threonine-protein kinase LATS1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform 3.
    Source sequence(s)
    AL358852, AL583963, BX276089
    Conserved Domains (3) summary
    cl21453
    Location:598 → 1012
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:11 → 38
    UBA_like_SF; UBA domain-like superfamily
    cl28087
    Location:343 → 491
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001350340.2 → NP_001337269.1  serine/threonine-protein kinase LATS1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform 4.
    Source sequence(s)
    AL358852, AL583963, BX276089
    Conserved Domains (3) summary
    cd05625
    Location:598 → 979
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl21463
    Location:11 → 38
    UBA_like_SF; UBA domain-like superfamily
    cl28087
    Location:343 → 491
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  4. NM_001350392.2 → NP_001337321.1  serine/threonine-protein kinase LATS1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes isoform 5.
    Source sequence(s)
    AL358852, AL583963, BX276089
    UniProtKB/TrEMBL
    Q59FN4
    Conserved Domains (2) summary
    cd05625
    Location:423 → 804
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl26464
    Location:9 → 312
    Atrophin-1; Atrophin-1 family

  5. NM_004690.4 → NP_004681.1  serine/threonine-protein kinase LATS1 isoform 1

    See identical proteins and their annotated locations for NP_004681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF104413, AL358852, AW021064, BX276089
    Consensus CDS
    CCDS34551.1
    UniProtKB/Swiss-Prot
    O95835, Q6PKD0
    Related
    ENSP00000437550.1, ENST00000543571.6
    Conserved Domains (3) summary
    smart00220
    Location:705 → 1010
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14397
    Location:103 → 143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cd05625
    Location:703 → 1084
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

RNA

  1. NR_073033.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
    Source sequence(s)
    AK310422, AW021064, BX276089

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    149658153..149718101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011474.2 → XP_016866963.1  serine/threonine-protein kinase LATS1 isoform X1

    Conserved Domains (3) summary
    cd14397
    Location:103 → 143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:703 → 1117
    PKc_like; Protein Kinases, catalytic domain
    cl28087
    Location:448 → 596
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. XM_024446583.2 → XP_024302351.1  serine/threonine-protein kinase LATS1 isoform X1

    Conserved Domains (3) summary
    cd14397
    Location:103 → 143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:703 → 1117
    PKc_like; Protein Kinases, catalytic domain
    cl28087
    Location:448 → 596
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  3. XM_047419518.1 → XP_047275474.1  serine/threonine-protein kinase LATS1 isoform X2

    UniProtKB/Swiss-Prot
    O95835, Q6PKD0
    Related
    ENSP00000253339.5, ENST00000253339.9

  4. XM_047419517.1 → XP_047275473.1  serine/threonine-protein kinase LATS1 isoform X1

  5. XM_047419521.1 → XP_047275477.1  serine/threonine-protein kinase LATS1 isoform X8

  6. XM_017011479.2 → XP_016866968.1  serine/threonine-protein kinase LATS1 isoform X6

    UniProtKB/TrEMBL
    Q59FN4

  7. XM_011536252.3 → XP_011534554.1  serine/threonine-protein kinase LATS1 isoform X4

    UniProtKB/TrEMBL
    Q59FN4
    Conserved Domains (3) summary
    smart00220
    Location:705 → 961
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14397
    Location:103 → 143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:703 → 961
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017011477.2 → XP_016866966.1  serine/threonine-protein kinase LATS1 isoform X3

  9. XM_047419519.1 → XP_047275475.1  serine/threonine-protein kinase LATS1 isoform X5

  10. XM_006715603.4 → XP_006715666.1  serine/threonine-protein kinase LATS1 isoform X7

    UniProtKB/TrEMBL
    Q59FN4
    Conserved Domains (3) summary
    smart00220
    Location:705 → 862
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14397
    Location:103 → 143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:703 → 863
    PKc_like; Protein Kinases, catalytic domain

  11. XM_047419522.1 → XP_047275478.1  serine/threonine-protein kinase LATS1 isoform X9

RNA

  1. XR_007059386.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    150857942..150917878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356744.1 → XP_054212719.1  serine/threonine-protein kinase LATS1 isoform X1

  2. XM_054356745.1 → XP_054212720.1  serine/threonine-protein kinase LATS1 isoform X1

  3. XM_054356747.1 → XP_054212722.1  serine/threonine-protein kinase LATS1 isoform X2

    UniProtKB/Swiss-Prot
    O95835, Q6PKD0

  4. XM_054356746.1 → XP_054212721.1  serine/threonine-protein kinase LATS1 isoform X1

  5. XM_054356753.1 → XP_054212728.1  serine/threonine-protein kinase LATS1 isoform X8

  6. XM_054356751.1 → XP_054212726.1  serine/threonine-protein kinase LATS1 isoform X6

  7. XM_054356749.1 → XP_054212724.1  serine/threonine-protein kinase LATS1 isoform X4

  8. XM_054356748.1 → XP_054212723.1  serine/threonine-protein kinase LATS1 isoform X3

  9. XM_054356750.1 → XP_054212725.1  serine/threonine-protein kinase LATS1 isoform X5

  10. XM_054356752.1 → XP_054212727.1  serine/threonine-protein kinase LATS1 isoform X7

  11. XM_054356754.1 → XP_054212729.1  serine/threonine-protein kinase LATS1 isoform X9

RNA

  1. XR_008487506.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95835.1 GenPept UniProtKB/Swiss-Prot:O95835

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