TMSB4Y thymosin beta 4 Y-linked [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMSB4Yprovided by HGNC
Official Full Name: thymosin beta 4 Y-linkedprovided by HGNC
Primary source: HGNC:HGNC:11882
See related: Ensembl:ENSG00000154620 MIM:400017; AllianceGenome:HGNC:11882
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TB4Y
Summary: This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 2.3), prostate (RPKM 2.2) and 19 other tissues See more
Orthologs: all
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Genomic context

Location:: Yq11.221

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	Y	NC_000024.10 (13703899..13706024)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	Y	NC_060948.1 (14610529..14612654)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	Y	NC_000024.9 (15815779..15817904)

Chromosome Y - NC_000024.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-183/TMSB4Y, a new potential signaling axis, involving in the progression of laryngeal cancer via modulating cell adhesion.
Title: miR-183/TMSB4Y, a new potential signaling axis, involving in the progression of laryngeal cancer via modulating cell adhesion.
Suggest Y chromosome gene TMSB4Y may function as a tumor suppressor gene in male breast cancer.
Title: TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.
T beta 4 is a key activator of NK cell cytotoxicity.
Title: Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.
TMSB4Y has been found to encode a novel HLA-A*3303-restricted minor histocompatibility H-Y antigen, revealed during cytotoxicity assays of T cell lines from a female-to-male hemopoietic stem cell transplantation patient.
Title: A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65843 (e-PCR)
- UniSTS:230509

G65844 (e-PCR)
- UniSTS:230510

RH45846 (e-PCR)
- UniSTS:90518

G34981 (e-PCR)
- UniSTS:22246

TMSB4Y_8894 (e-PCR)
- UniSTS:467944

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin polymerization or depolymerization	TAS Traceable Author Statement more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymosin beta-4, Y-chromosomal

Names: thymosin, beta 4, Y chromosome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.