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GPRC5A G protein-coupled receptor class C group 5 member A [ Homo sapiens (human) ]

Gene ID: 9052, updated on 7-Apr-2024

Summary

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Official Symbol
GPRC5Aprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Aprovided by HGNC
Primary source
HGNC:HGNC:9836
See related
Ensembl:ENSG00000013588 MIM:604138; AllianceGenome:HGNC:9836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI3; TIG1; RAIG1; GPCR5A; PEIG-1
Summary
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues See more
Orthologs
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Genomic context

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See GPRC5A in Genome Data Viewer
Location:
12p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12891562..12917937)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12765164..12791546)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13044496..13070871)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902881 Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene ribosomal protein L13a pseudogene 20 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13058787 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13059781 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13073965 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13075202 Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene G protein-coupled receptor class C group 5 member D Neighboring gene small nucleolar RNA SNORD88

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma. Wang YJ, et al. J Biol Regul Homeost Agents, 2021 Jul 30. PMID 34350749
  2. Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis. Dai L, et al. PLoS One, 2021. PMID 33788883, Free PMC Article
  3. Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer. Moyano-Galceran L, et al. EMBO Mol Med, 2020 Apr 7. PMID 32115889, Free PMC Article
  4. RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway. Jin C, et al. Biochem Biophys Res Commun, 2020 Apr 2. PMID 32014253
  5. GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer. Sawada Y, et al. Int J Cancer, 2020 Mar 1. PMID 31276604

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
    Title: Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
  2. The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
    Title: The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
  3. RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
    Title: RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
  4. Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
    Title: Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
  5. Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
    Title: Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
  6. GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
    Title: GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
  7. Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
    Title: Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
  8. RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.
    Title: RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.
  9. Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
    Title: Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
  10. RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway.
    Title: RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
retinoic acid-induced protein 3
Names
G-protein coupled receptor family C group 5 member A
TPA induced gene 1
orphan G-protein-coupling receptor PEIG-1
phorbol ester induced gene 1
phorbol ester induced protein-1
retinoic acid induced 3
retinoic acid responsive
retinoic acid-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003979.4 → NP_003970.1  retinoic acid-induced protein 3

    See identical proteins and their annotated locations for NP_003970.1

    Status: REVIEWED

    Source sequence(s)
    AC007688, AF095448, AI587426, AK122672
    Consensus CDS
    CCDS8657.1
    UniProtKB/Swiss-Prot
    B3KV45, O95357, Q8NFJ5
    UniProtKB/TrEMBL
    A8K556
    Related
    ENSP00000014914.6, ENST00000014914.6
    Conserved Domains (1) summary
    cd15279
    Location:26 → 270
    7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    12891562..12917937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    12765164..12791546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFJ5.2 GenPept UniProtKB/Swiss-Prot:Q8NFJ5

Gene LinkOut

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