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CCNC cyclin C [ Homo sapiens (human) ]

Gene ID: 892, updated on 3-Apr-2024

Summary

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Official Symbol
CCNCprovided by HGNC
Official Full Name
cyclin Cprovided by HGNC
Primary source
HGNC:HGNC:1581
See related
Ensembl:ENSG00000112237 MIM:123838; AllianceGenome:HGNC:1581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CycC; SRB11; hSRB11
Summary
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 29.5), gall bladder (RPKM 20.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6q16.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (99542387..99568814, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (100716675..100743083, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99990263..100016690, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene ubiquitin specific peptidase 45 Neighboring gene NANOG hESC enhancer GRCh37_chr6:99904596-99905315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17417 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:99962307-99963214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:99963215-99964120 Neighboring gene uncharacterized LOC124901365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24862 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:100023517-100023714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24863 Neighboring gene ribosomal protein S3 pseudogene 5 Neighboring gene CCNC and PRDM13 intergenic region DNase I hypersensitve site DHS6S1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100051429-100052268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100061850-100062398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17423 Neighboring gene PR/SET domain 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. Tang M, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34197614, Free PMC Article
  2. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Miyata Y, et al. Stem Cells, 2010 Feb. PMID 19967789, Free PMC Article
  3. Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. Makkonen KM, et al. J Mol Biol, 2009 Oct 23. PMID 19683536
  4. Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions. Katona RL, et al. Acta Biol Hung, 2007 Mar. PMID 17385550
  5. Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. Ohata N, et al. Int J Mol Med, 2006 Dec. PMID 17089020

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
    Title: Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.
  2. Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.
    Title: Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2.
  3. cyclin C binding stimulates the reduction of low-GTPase activity Drp1 oligomers into dimers capable of producing high-GTPase activity filaments.
    Title: Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.
  4. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
    Title: Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
  5. our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression.
    Title: mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
  6. results suggest that CCNC temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes.
    Title: Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.
  7. Cancer-mediated CDK8 point mutations (D173A and D189N) change the binding pattern of cdk8 to its partner, CycC.
    Title: All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.
  8. cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation
    Title: Cyclin C is a haploinsufficient tumour suppressor.
  9. analysis of the structure-kinetic relationship of the cyclin-dependent kinase 8 (CDK8)/cyclin C (CycC) complex
    Title: Structure-kinetic relationship study of CDK8/CycC specific compounds.
  10. Silencing beta-catenin gene may induce changes of cell cycle and in cyclin B1 and cyclin C protein expression.
    Title: The effect of cell cycle and expression of cyclin B1 and cyclin C protein in hepatocellular carcinoma cell line HepG2 and SMMC-7721 after of silencing β-catenin gene.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes cyclin c, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G0 to G1 transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CKM complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of CKM complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-C
Names
SRB11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013399.2 → NP_001013417.1  cyclin-C isoform b

    See identical proteins and their annotated locations for NP_001013417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1, that results in the use of a downstream translational start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC056153, BM788717
    Consensus CDS
    CCDS47461.1
    UniProtKB/TrEMBL
    E5RFX8
    Related
    ENSP00000430014.1, ENST00000523799.5
    Conserved Domains (2) summary
    cd20514
    Location:69 → 160
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
    cl40454
    Location:1 → 61
    CYCLIN_SF; Cyclin box fold superfamily

  2. NM_001363537.2 → NP_001350466.1  cyclin-C isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL137784
    Consensus CDS
    CCDS87420.1
    UniProtKB/TrEMBL
    E5RFK5, H0YBQ5
    Related
    ENSP00000430381.1, ENST00000520371.5
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

  3. NM_005190.4 → NP_005181.2  cyclin-C isoform a

    See identical proteins and their annotated locations for NP_005181.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC041123, BC056153
    Consensus CDS
    CCDS34502.1
    UniProtKB/Swiss-Prot
    B4DPZ1, P24863, Q9H543
    UniProtKB/TrEMBL
    Q7Z4L3
    Related
    ENSP00000428982.1, ENST00000520429.6
    Conserved Domains (2) summary
    cd20513
    Location:40 → 146
    CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins
    cd20514
    Location:154 → 245
    CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    99542387..99568814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419485.1 → XP_047275441.1  cyclin-C isoform X2

  2. XM_047419489.1 → XP_047275445.1  cyclin-C isoform X5

    Related
    ENSP00000427885.1, ENST00000524049.5

  3. XM_047419484.1 → XP_047275440.1  cyclin-C isoform X1

    UniProtKB/TrEMBL
    E5RFK5
    Related
    ENSP00000430294.1, ENST00000518714.5

  4. XM_047419486.1 → XP_047275442.1  cyclin-C isoform X3

  5. XM_047419487.1 → XP_047275443.1  cyclin-C isoform X4

    UniProtKB/TrEMBL
    G5E954
    Related
    ENSP00000487040.1, ENST00000627680.2

  6. XM_011536232.4 → XP_011534534.1  cyclin-C isoform X6

    Conserved Domains (1) summary
    cd00043
    Location:48 → 143
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  7. XM_017011436.3 → XP_016866925.1  cyclin-C isoform X7

    UniProtKB/TrEMBL
    Q5JV82

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    100716675..100743083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356692.1 → XP_054212667.1  cyclin-C isoform X2

  2. XM_054356695.1 → XP_054212670.1  cyclin-C isoform X5

  3. XM_054356693.1 → XP_054212668.1  cyclin-C isoform X3

  4. XM_054356691.1 → XP_054212666.1  cyclin-C isoform X1

    UniProtKB/TrEMBL
    E5RFK5

  5. XM_054356694.1 → XP_054212669.1  cyclin-C isoform X4

    UniProtKB/TrEMBL
    G5E954

  6. XM_054356697.1 → XP_054212672.1  cyclin-C isoform X7

  7. XM_054356696.1 → XP_054212671.1  cyclin-C isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24863.2 GenPept UniProtKB/Swiss-Prot:P24863

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