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IL1RL2 interleukin 1 receptor like 2 [ Homo sapiens (human) ]

Gene ID: 8808, updated on 11-Apr-2024

Summary

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Official Symbol
IL1RL2provided by HGNC
Official Full Name
interleukin 1 receptor like 2provided by HGNC
Primary source
HGNC:HGNC:5999
See related
Ensembl:ENSG00000115598 MIM:604512; AllianceGenome:HGNC:5999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
2q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102186973..102243086)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102645259..102701349)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102803433..102856462)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102657879-102659078 Neighboring gene uncharacterized LOC107985926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:102674234-102674816 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102775959-102776153 Neighboring gene IL1R1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102803139-102803668 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:102813537-102814736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851302-102851802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851803-102852303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102854175-102855374 Neighboring gene Sharpr-MPRA regulatory region 14071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2 Neighboring gene interleukin 1 receptor like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications. Manzanares-Meza LD, et al. J Interferon Cytokine Res, 2022 Feb. PMID 35171706
  2. IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose-dependently activated via IL-36β and induces CD4+ lymphocyte proliferation. Penha R, et al. Cytokine, 2016 Sep. PMID 27269181
  3. Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9. Mutamba S, et al. Eur J Immunol, 2012 Mar. PMID 22144259
  4. Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement. Sullivan GP, et al. Sci Immunol, 2022 Dec 23. PMID 36525507
  5. Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease. Tomuschat C, et al. Pediatr Surg Int, 2017 Feb. PMID 27853811

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
    Title: Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
  2. In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.
    Title: In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.
  3. Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.
    Title: Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.
  4. Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement.
    Title: Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement.
  5. Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.
    Title: Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.
  6. Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
    Title: Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
  7. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor.
    Title: IL-36γ has proinflammatory effects on human endothelial cells.
  8. All human blood lymphocytes express IL-36R.
    Title: IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose-dependently activated via IL-36β and induces CD4+ lymphocyte proliferation.
  9. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention.
    Title: IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.
  10. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP.
    Title: Structural and Functional Attributes of the Interleukin-36 Receptor.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
EBI GWAS Catalog
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-like 2
Names
IL-1 receptor-related protein 2
IL-36 receptor
interleukin-1 receptor-related protein 2
NP_001338375.1
NP_001338376.1
NP_001338377.1
NP_001338378.1
NP_001338379.1
NP_003845.2
XP_006712885.1
XP_011510393.2
XP_011510394.2
XP_011510395.2
XP_011510396.1
XP_011510398.2
XP_016860663.2
XP_047302120.1
XP_047302121.1
XP_047302122.1
XP_054200322.1
XP_054200323.1
XP_054200324.1
XP_054200325.1
XP_054200326.1
XP_054200327.1
XP_054200328.1
XP_054200329.1
XP_054200330.1
XP_054200331.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351446.2 → NP_001338375.1  interleukin-1 receptor-like 2 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AC007248, AK315334, BC107064, CA448166
    Consensus CDS
    CCDS2056.1
    UniProtKB/Swiss-Prot
    A4FU63, Q13525, Q45H74, Q53TU8, Q587I8, Q9HB29
    UniProtKB/TrEMBL
    B2RCY7
    Conserved Domains (3) summary
    pfam01582
    Location:386 → 536
    TIR; TIR domain
    cd05757
    Location:130 → 218
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:26 → 112
    Ig; Immunoglobulin domain

  2. NM_001351447.1 → NP_001338376.1  interleukin-1 receptor-like 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform b.
    Source sequence(s)
    AC007271, AF284434, BC107064, CA448166
    Consensus CDS
    CCDS86867.1
    Related
    ENSP00000413348.2, ENST00000441515.3
    Conserved Domains (2) summary
    pfam01582
    Location:268 → 418
    TIR; TIR domain
    cl11960
    Location:46 → 100
    Ig; Immunoglobulin domain

  3. NM_001351448.1 → NP_001338377.1  interleukin-1 receptor-like 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform c.
    Source sequence(s)
    AC007248, AC007271
    Conserved Domains (2) summary
    pfam01582
    Location:244 → 394
    TIR; TIR domain
    cl11960
    Location:46 → 99
    Ig; Immunoglobulin domain

  4. NM_001351449.2 → NP_001338378.1  interleukin-1 receptor-like 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC007248, AC007271
    Conserved Domains (2) summary
    pfam01582
    Location:235 → 385
    TIR; TIR domain
    cl11960
    Location:11 → 67
    Ig; Immunoglobulin domain

  5. NM_001351450.2 → NP_001338379.1  interleukin-1 receptor-like 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform d.
    Source sequence(s)
    AC007248, AC007271
    Conserved Domains (2) summary
    pfam01582
    Location:235 → 385
    TIR; TIR domain
    cl11960
    Location:11 → 67
    Ig; Immunoglobulin domain

  6. NM_003854.4 → NP_003845.2  interleukin-1 receptor-like 2 isoform a precursor

    See identical proteins and their annotated locations for NP_003845.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes the longest isoform (a).
    Source sequence(s)
    AF284434, BC107064, CA448166
    Consensus CDS
    CCDS2056.1
    UniProtKB/Swiss-Prot
    A4FU63, Q13525, Q45H74, Q53TU8, Q587I8, Q9HB29
    UniProtKB/TrEMBL
    B2RCY7
    Related
    ENSP00000264257.2, ENST00000264257.7
    Conserved Domains (3) summary
    pfam01582
    Location:386 → 536
    TIR; TIR domain
    cd05757
    Location:130 → 218
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:26 → 112
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    102186973..102243086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005174.3 → XP_016860663.2  interleukin-1 receptor-like 2 isoform X3

  2. XM_011512096.2 → XP_011510398.2  interleukin-1 receptor-like 2 isoform X7

  3. XM_011512091.2 → XP_011510393.2  interleukin-1 receptor-like 2 isoform X1

  4. XM_011512093.2 → XP_011510395.2  interleukin-1 receptor-like 2 isoform X4

  5. XM_047446165.1 → XP_047302121.1  interleukin-1 receptor-like 2 isoform X6

  6. XM_011512092.2 → XP_011510394.2  interleukin-1 receptor-like 2 isoform X2

  7. XM_011512094.2 → XP_011510396.1  interleukin-1 receptor-like 2 isoform X5

    See identical proteins and their annotated locations for XP_011510396.1

    UniProtKB/TrEMBL
    B2RCY7
    Conserved Domains (4) summary
    cd05757
    Location:130 → 218
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:40 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:386 → 536
    TIR; TIR domain
    cl11960
    Location:26 → 112
    Ig; Immunoglobulin domain

  8. XM_047446164.1 → XP_047302120.1  interleukin-1 receptor-like 2 isoform X1

  9. XM_006712822.4 → XP_006712885.1  interleukin-1 receptor-like 2 isoform X8

    Conserved Domains (2) summary
    pfam01582
    Location:235 → 385
    TIR; TIR domain
    cl11960
    Location:11 → 67
    Ig; Immunoglobulin domain

  10. XM_047446166.1 → XP_047302122.1  interleukin-1 receptor-like 2 isoform X9

RNA

  1. XR_923053.3 RNA Sequence

  2. XR_007083521.1 RNA Sequence

  3. XR_007083520.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102645259..102701349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344349.1 → XP_054200324.1  interleukin-1 receptor-like 2 isoform X3

  2. XM_054344354.1 → XP_054200329.1  interleukin-1 receptor-like 2 isoform X7

  3. XM_054344347.1 → XP_054200322.1  interleukin-1 receptor-like 2 isoform X1

  4. XM_054344350.1 → XP_054200325.1  interleukin-1 receptor-like 2 isoform X4

  5. XM_054344353.1 → XP_054200328.1  interleukin-1 receptor-like 2 isoform X6

  6. XM_054344348.1 → XP_054200323.1  interleukin-1 receptor-like 2 isoform X2

  7. XM_054344351.1 → XP_054200326.1  interleukin-1 receptor-like 2 isoform X5

  8. XM_054344352.1 → XP_054200327.1  interleukin-1 receptor-like 2 isoform X1

  9. XM_054344355.1 → XP_054200330.1  interleukin-1 receptor-like 2 isoform X8

  10. XM_054344356.1 → XP_054200331.1  interleukin-1 receptor-like 2 isoform X9

RNA

  1. XR_008486578.1 RNA Sequence

  2. XR_008486577.1 RNA Sequence

  3. XR_008486576.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HB29.2 GenPept UniProtKB/Swiss-Prot:Q9HB29

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