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OASL 2'-5'-oligoadenylate synthetase like [ Homo sapiens (human) ]

Gene ID: 8638, updated on 5-Mar-2024

Summary

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Official Symbol
OASLprovided by HGNC
Official Full Name
2'-5'-oligoadenylate synthetase likeprovided by HGNC
Primary source
HGNC:HGNC:8090
See related
Ensembl:ENSG00000135114 MIM:603281; AllianceGenome:HGNC:8090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
Summary
Enables DNA binding activity and double-stranded RNA binding activity. Involved in several processes, including interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; and positive regulation of RIG-I signaling pathway. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues See more
Orthologs
all
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Genomic context

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See OASL in Genome Data Viewer
Location:
12q24.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121017761..121039246, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121007355..121028848, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121455564..121477049, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:121410688-121411215 Neighboring gene HNF1A antisense RNA 1 Neighboring gene HNF1 homeobox A Neighboring gene chromosome 12 open reading frame 43 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:121453469-121453984 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:121454193-121454386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121476213-121476714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121476715-121477214 Neighboring gene Sharpr-MPRA regulatory region 13012 Neighboring gene uncharacterized LOC105378258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7156 Neighboring gene 2'-5' oligoadenylate synthetase like 2, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:121530887-121531388 Neighboring gene uncharacterized LOC105370031 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion. Leisching G, et al. Mol Immunol, 2020 Feb. PMID 31855809
  2. 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1. Dhar J, et al. J Virol, 2015 Oct. PMID 26178980, Free PMC Article
  3. Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Ibsen MS, et al. Nucleic Acids Res, 2015 May 26. PMID 25925578, Free PMC Article
  4. Identification of OASL d, a splice variant of human OASL, with antiviral activity. Guo X, et al. Int J Biochem Cell Biol, 2012 Jul. PMID 22531715
  5. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. Su X, et al. J Hepatol, 2008 Aug. PMID 18571276, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OASL regulates pro-inflammatory mediators such as cytokines and chemokines which suppress intracellular mycobacterial growth and survival.
    Title: 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion.
  2. these resulta define distinct mechanisms by which OASL differentially regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feedback regulator of cGAS
    Title: Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
  3. These data uncover a promycobacterial role for STING-dependent OASL production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen.
    Title: STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.
  4. OASL acts as a cellular antiviral protein and RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
    Title: 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.
  5. Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes.
    Title: Differential upregulation of human 2'5'OAS genes on systemic sclerosis: Detection of increased basal levels of OASL and OAS2 genes through a qPCR based assay.
  6. these findings show a mechanism by which human OASL contributes to host antiviral responses by enhancing RIG-I activation.
    Title: Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
  7. we propose that VSV treatment combined with the selective regulation of genes such as STAT1 and OASL2 will improve therapeutic outcomes for CUG2-overexpressing tumors
    Title: Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling.
  8. variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Title: Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
  9. The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein.
    Title: Differential regulation of the OASL and OAS1 genes in response to viral infections.
  10. The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls.
    Title: [Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus].
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
EBI GWAS Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
EBI GWAS Catalog
New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
EBI GWAS Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of 2'-5'-oligoadenylate synthetase-like (OASL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of 2'-5'-oligoadenylate synthetase-like (OASL; p59-OASL) in immature dendritic cells and monocyte-derived macrophages PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of OASL in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear thyroid hormone receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-27-mediated signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
2'-5'-oligoadenylate synthase-like protein
Names
2'-5'-OAS-RP
2'-5'-OAS-related protein
59 kDa 2'-5'-oligoadenylate synthase-like protein
59 kDa 2'-5'-oligoadenylate synthetase-like protein
TR-interacting protein 14
thyroid receptor-interacting protein 14

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261825.2 → NP_001248754.1  2'-5'-oligoadenylate synthase-like protein isoform c

    See identical proteins and their annotated locations for NP_001248754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC079602
    Consensus CDS
    CCDS73536.1
    UniProtKB/Swiss-Prot
    Q15646
    Related
    ENSP00000479512.1, ENST00000620239.5
    Conserved Domains (5) summary
    cd05400
    Location:29 → 212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    smart00213
    Location:304 → 372
    UBQ; Ubiquitin homologues
    pfam00240
    Location:309 → 375
    ubiquitin; Ubiquitin family
    pfam10421
    Location:167 → 219
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl00155
    Location:224 → 303
    UBQ; Ubiquitin-like proteins

  2. NM_001395418.1 → NP_001382347.1  2'-5'-oligoadenylate synthase-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC079602
    Consensus CDS
    CCDS9212.1
    Related
    ENSP00000444127.2, ENST00000543677.2
    Conserved Domains (2) summary
    cd05400
    Location:29 → 212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:168 → 219
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  3. NM_001395419.1 → NP_001382348.1  2'-5'-oligoadenylate synthase-like protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC079602
    Consensus CDS
    CCDS91762.1
    UniProtKB/TrEMBL
    A0A7P0T9H8, A0A7P0TB39
    Related
    ENSP00000505685.1, ENST00000680620.1
    Conserved Domains (2) summary
    cd05400
    Location:29 → 212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:168 → 349
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  4. NM_003733.4 → NP_003724.1  2'-5'-oligoadenylate synthase-like protein isoform a

    See identical proteins and their annotated locations for NP_003724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC079602
    Consensus CDS
    CCDS9211.1
    UniProtKB/Swiss-Prot
    B2RAZ2, I1YDD2, O75686, Q15646, Q17R95, Q9Y6K6, Q9Y6K7
    UniProtKB/TrEMBL
    B3KN79
    Related
    ENSP00000257570.4, ENST00000257570.10
    Conserved Domains (4) summary
    cd05400
    Location:29 → 212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    cd01811
    Location:354 → 433
    OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
    pfam00240
    Location:436 → 506
    ubiquitin; Ubiquitin family
    pfam10421
    Location:168 → 351
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  5. NM_198213.3 → NP_937856.1  2'-5'-oligoadenylate synthase-like protein isoform b

    See identical proteins and their annotated locations for NP_937856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC079602
    Consensus CDS
    CCDS9212.1
    UniProtKB/Swiss-Prot
    Q15646
    Related
    ENSP00000341125.5, ENST00000339275.10
    Conserved Domains (2) summary
    cd05400
    Location:29 → 212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:168 → 219
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    121017761..121039246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429803.1 → XP_047285759.1  2'-5'-oligoadenylate synthase-like protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    121007355..121028848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373702.1 → XP_054229677.1  2'-5'-oligoadenylate synthase-like protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15646.2 GenPept UniProtKB/Swiss-Prot:Q15646

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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