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UBASH3B ubiquitin associated and SH3 domain containing B [ Homo sapiens (human) ]

Gene ID: 84959, updated on 31-Mar-2024

Summary

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Official Symbol
UBASH3Bprovided by HGNC
Official Full Name
ubiquitin associated and SH3 domain containing Bprovided by HGNC
Primary source
HGNC:HGNC:29884
See related
Ensembl:ENSG00000154127 MIM:609201; AllianceGenome:HGNC:29884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p70; STS1; STS-1; TULA2; TULA-2
Summary
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 7.0), placenta (RPKM 6.8) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q24.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (122655722..122814473)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (122683359..122842181)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122526430..122685181)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 592, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122489240-122489740 Neighboring gene Sharpr-MPRA regulatory region 14714 Neighboring gene glutamate-ammonia ligase pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:122526335-122526836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4009 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:122541852-122542352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:122558486-122558986 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122615185-122616152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5669 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:122625977-122626130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:122673978-122674720 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:122675524-122676042 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122683300-122683908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122683909-122684516 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122702884-122703556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5674 Neighboring gene cytotoxic and regulatory T cell molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4010 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122791170-122791781 Neighboring gene junctional cadherin complex regulator Neighboring gene RNA, U4 small nuclear 23, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling. Cutler JA, et al. Leukemia, 2020 Jan. PMID 31399640, Free PMC Article
  2. The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis. Mian AA, et al. Leukemia, 2019 Sep. PMID 30962580, Free PMC Article
  3. Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population. Shahriyari E, et al. Curr Eye Res, 2019 Feb. PMID 30289285
  4. TULA-family proteins: Jacks of many trades and then some. Tsygankov AY. J Cell Physiol, 2018 Jan. PMID 30076707
  5. Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein. Yao Y, et al. Biochimie, 2021 May. PMID 33556471

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
    Title: FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
  2. Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCdelta protein.
    Title: Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.
  3. An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
    Title: An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
  4. These studies help define a critical role of Ubash3b in leukemia
    Title: Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling.
  5. the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population. We could not find any susceptibility role of this genetic locus for posterior uveitis in Behcet's disease.
    Title: Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population.
  6. Sts-1 is a negative regulator.
    Title: The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.
  7. UBASH3A/STS-2/TULA exhibits substantial homology to UBASH3B/STS-1/TULA-2, but possesses only a small fraction of phosphatase activity of UBASH3B/STS-1/TULA-2, and thus, its regulatory effect may be based also on the phosphatase-independent mechanisms. Critical physiologic effects of these proteins have been demonstrated in T lymphocytes, platelets, stem cells, and other important cell types.
    Title: TULA-family proteins: Jacks of many trades and then some.
  8. Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70.
    Title: Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.
  9. The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation.
    Title: Identification of STS-1 as a novel ShcA-binding protein.
  10. The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
    Title: UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1959, MGC15437

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen-activated tyrosine kinase receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-associated and SH3 domain-containing protein B
Names
Cbl-interacting protein Sts-1
SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
T-cell ubiquitin ligand 2
cbl-interacting protein p70
nm23-phosphorylated unknown substrate
suppressor of T-cell receptor signaling 1
tyrosine-protein phosphatase STS1/TULA2
NP_001350294.1
NP_116262.2
XP_005271769.1
XP_011541343.1
XP_054226245.1
XP_054226246.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363365.2 → NP_001350294.1  ubiquitin-associated and SH3 domain-containing protein B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP002762
    Conserved Domains (2) summary
    cd07067
    Location:351 → 563
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:221 → 282
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

  2. NM_032873.5 → NP_116262.2  ubiquitin-associated and SH3 domain-containing protein B isoform 1

    See identical proteins and their annotated locations for NP_116262.2

    Status: VALIDATED

    Source sequence(s)
    AK075203, AP002762, BC007541, CR741636
    Consensus CDS
    CCDS31694.1
    UniProtKB/Swiss-Prot
    Q53GT5, Q53GT8, Q8NBV7, Q8TF42, Q96IG9, Q96NZ2
    Related
    ENSP00000284273.5, ENST00000284273.6
    Conserved Domains (3) summary
    cd07067
    Location:386 → 598
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:256 → 317
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cd14301
    Location:39 → 76
    UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    122655722..122814473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271712.4 → XP_005271769.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

    Conserved Domains (3) summary
    cd07067
    Location:414 → 626
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:284 → 345
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cl21463
    Location:83 → 104
    UBA_like_SF; UBA domain-like superfamily

  2. XM_011543041.3 → XP_011541343.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

    Conserved Domains (2) summary
    cd07067
    Location:367 → 579
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:237 → 298
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    122683359..122842181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370270.1 → XP_054226245.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

  2. XM_054370271.1 → XP_054226246.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TF42.2 GenPept UniProtKB/Swiss-Prot:Q8TF42

Gene LinkOut

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