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RGS5 regulator of G protein signaling 5 [ Homo sapiens (human) ]

Gene ID: 8490, updated on 3-Apr-2024

Summary

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Official Symbol
RGS5provided by HGNC
Official Full Name
regulator of G protein signaling 5provided by HGNC
Primary source
HGNC:HGNC:10001
See related
Ensembl:ENSG00000143248 MIM:603276; AllianceGenome:HGNC:10001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
Summary
This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]
Expression
Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (163142299..163321735, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (162487178..162666666, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163112089..163291525, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC124904446 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene regulator of G protein signaling 4 Neighboring gene NANOG hESC enhancer GRCh37_chr1:163101622-163102196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_592 Neighboring gene RGS5 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163172770-163173435 Neighboring gene uncharacterized LOC127814295 Neighboring gene TRNT1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2014 Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163369660-163370204 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:163384530-163384653 Neighboring gene eukaryotic translation initiation factor 3 subunit J pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. Enström A, et al. Biol Open, 2022 Oct 15. PMID 36111549, Free PMC Article
  2. Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism. Li X, et al. BMC Endocr Disord, 2022 Jun 9. PMID 35681135, Free PMC Article
  3. RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese. Hsu LC, et al. J Chin Med Assoc, 2020 Mar. PMID 32080025
  4. Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation. Zhang X, et al. Sci Rep, 2020 Feb 10. PMID 32041970, Free PMC Article
  5. Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease. Li Y, et al. Cardiovasc Res, 2021 Jan 1. PMID 31605122

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
    Title: Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
  2. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
    Title: RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
  3. Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
    Title: Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
  4. Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
    Title: Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
  5. RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
    Title: RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
  6. RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
    Title: RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
  7. Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
    Title: Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
  8. Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
    Title: Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
  9. Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
    Title: Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
  10. Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
    Title: Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Essential hypertension, genetic
MedGen: CN305331 OMIM: 145500 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
EBI GWAS Catalog
Genome-wide association study of liver enzymes in korean children.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 5
Names
regulator of G-protein signalling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027731.2 RefSeqGene

    Range
    123876..184493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195303.3 → NP_001182232.1  regulator of G-protein signaling 5 isoform 2

    See identical proteins and their annotated locations for NP_001182232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AJ891044, AL157502, AL583850, BX537427, DA699380
    Consensus CDS
    CCDS55652.1
    UniProtKB/Swiss-Prot
    O15539
    Related
    ENSP00000432313.1, ENST00000527988.1
    Conserved Domains (1) summary
    cl02565
    Location:1 → 70
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001254748.2 → NP_001241677.1  regulator of G-protein signaling 5 isoform 2

    See identical proteins and their annotated locations for NP_001241677.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AL157502, AL583850, BP292867, BX537427
    Consensus CDS
    CCDS55652.1
    UniProtKB/Swiss-Prot
    O15539
    Related
    ENSP00000480891.1, ENST00000618415.4
    Conserved Domains (1) summary
    cl02565
    Location:1 → 70
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. NM_001254749.2 → NP_001241678.1  regulator of G-protein signaling 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
    Source sequence(s)
    AL157502, AL583850, BU172751, BX537427, DA699380
    Consensus CDS
    CCDS58041.1
    UniProtKB/TrEMBL
    B2RD05
    Related
    ENSP00000433001.1, ENST00000530507.5
    Conserved Domains (1) summary
    cd08717
    Location:65 → 182
    RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

  4. NM_001414472.1 → NP_001401401.1  regulator of G-protein signaling 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL451063, AL499616, AL583850, AL592435

  5. NM_001414473.1 → NP_001401402.1  regulator of G-protein signaling 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL451063, AL499616, AL583850, AL592435

  6. NM_001414474.1 → NP_001401403.1  regulator of G-protein signaling 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL451063, AL499616, AL583850, AL592435

  7. NM_001414475.1 → NP_001401404.1  regulator of G-protein signaling 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL451063, AL499616, AL583850, AL592435

  8. NM_001414476.1 → NP_001401405.1  regulator of G-protein signaling 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL499616, AL583850, AL592435

  9. NM_001414477.1 → NP_001401406.1  regulator of G-protein signaling 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL499616, AL583850, AL592435

  10. NM_001414478.1 → NP_001401407.1  regulator of G-protein signaling 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL499616, AL583850, AL592435

  11. NM_001414479.1 → NP_001401408.1  regulator of G-protein signaling 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL499616, AL583850, AL592435

  12. NM_003617.4 → NP_003608.1  regulator of G-protein signaling 5 isoform 1

    See identical proteins and their annotated locations for NP_003608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions.
    Source sequence(s)
    AL451063, AL583850, BC030059
    Consensus CDS
    CCDS1244.1
    UniProtKB/Swiss-Prot
    E9PMP5, O15539, Q53XA9, Q599J0
    UniProtKB/TrEMBL
    B2RD05
    Related
    ENSP00000319308.5, ENST00000313961.10
    Conserved Domains (1) summary
    cd08717
    Location:65 → 178
    RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    163142299..163321735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    162487178..162666666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025226.1: Suppressed sequence

    Description
    NM_025226.1: This RefSeq was permanently suppressed because it is UTR sequence and contains the wrong CDS.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15539.1 GenPept UniProtKB/Swiss-Prot:O15539

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