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ADGRE3 adhesion G protein-coupled receptor E3 [ Homo sapiens (human) ]

Gene ID: 84658, updated on 11-Apr-2024

Summary

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Official Symbol
ADGRE3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E3provided by HGNC
Primary source
HGNC:HGNC:23647
See related
Ensembl:ENSG00000131355 MIM:606101; AllianceGenome:HGNC:23647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMR3
Summary
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Expression
Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14600117..14674844, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14728189..14801146, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14729929..14785656, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14177 Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene C-type lectin domain containing 17A Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10261 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene zinc finger protein 333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women]. Zhou X, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2021 Oct 20. PMID 34755660, Free PMC Article
  2. EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. Kane AJ, et al. Neuroreport, 2010 Nov 17. PMID 20827226, Free PMC Article
  3. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. Matmati M, et al. J Leukoc Biol, 2007 Feb. PMID 17108056
  4. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. Stacey M, et al. J Biol Chem, 2001 Jun 1. PMID 11279179
  5. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. Plager DA, et al. PLoS One, 2010 Jul 6. PMID 20625511, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].
    Title: [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].
  2. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, impetus is provided to explore EMR-3 as a potential therapeutic target.
    Title: EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target.
  3. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3.
    Title: Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  5. The expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes.
    Title: The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor E3
Names
EGF-like module receptor 3
EGF-like module-containing mucin-like hormone receptor-like 3
egf-like module containing, mucin-like, hormone receptor-like 3
egf-like module-containing mucin-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289158.2 → NP_001276087.1  adhesion G protein-coupled receptor E3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AF239764, AK298653, AL832663, AY358817, BC128053
    Consensus CDS
    CCDS74297.1
    UniProtKB/TrEMBL
    A8K4E4
    Related
    ENSP00000340758.4, ENST00000344373.8
    Conserved Domains (2) summary
    pfam01825
    Location:252 → 292
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:301 → 542
    7tm_4; Olfactory receptor

  2. NM_001289159.2 → NP_001276088.1  adhesion G protein-coupled receptor E3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AF239764, AK298653, BC128053
    Consensus CDS
    CCDS74296.1
    UniProtKB/TrEMBL
    B7Z5A1, E7EW83
    Related
    ENSP00000396208.2, ENST00000443157.6
    Conserved Domains (2) summary
    pfam01825
    Location:178 → 218
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:227 → 468
    7tm_4; Olfactory receptor

  3. NM_032571.5 → NP_115960.2  adhesion G protein-coupled receptor E3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_115960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF239764, AK298653, AL832663, BC121130, BC128053
    Consensus CDS
    CCDS12315.1
    UniProtKB/Swiss-Prot
    Q9BY15
    UniProtKB/TrEMBL
    A8K4E4
    Related
    ENSP00000253673.4, ENST00000253673.6
    Conserved Domains (3) summary
    cd00054
    Location:67 → 104
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01825
    Location:304 → 344
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:353 → 594
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    14600117..14674844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528374.3 → XP_011526676.1  adhesion G protein-coupled receptor E3 isoform X1

    UniProtKB/TrEMBL
    A8K4E4
    Conserved Domains (3) summary
    cd00054
    Location:50 → 87
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01825
    Location:287 → 327
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:336 → 577
    7tm_4; Olfactory receptor

  2. XM_047439546.1 → XP_047295502.1  adhesion G protein-coupled receptor E3 isoform X2

RNA

  1. XR_001753772.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14728189..14801146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322398.1 → XP_054178373.1  adhesion G protein-coupled receptor E3 isoform X1

  2. XM_054322399.1 → XP_054178374.1  adhesion G protein-coupled receptor E3 isoform X2

RNA

  1. XR_008485210.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152939.1: Suppressed sequence

    Description
    NM_152939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BY15.2 GenPept UniProtKB/Swiss-Prot:Q9BY15

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