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FNDC1 fibronectin type III domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84624, updated on 3-Apr-2024

Summary

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Official Symbol
FNDC1provided by HGNC
Official Full Name
fibronectin type III domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21184
See related
Ensembl:ENSG00000164694 MIM:609991; AllianceGenome:HGNC:21184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGS8; FNDC2; MEL4B3; bA243O10.1; dJ322A24.1
Summary
Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in gall bladder (RPKM 10.5), thyroid (RPKM 9.5) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
6q25.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (159169400..159272108)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (160415015..160517654)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159590432..159693140)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TAGAP antisense RNA 1 Neighboring gene MPRA-validated peak6279 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25382 Neighboring gene MPRA-validated peak6280 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:159461684-159462883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25383 Neighboring gene uncharacterized LOC112267968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25384 Neighboring gene T cell activation RhoGTPase activating protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25385 Neighboring gene uncharacterized LOC124901449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25386 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159538123-159538330 Neighboring gene VISTA enhancer hs2576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159591287-159591786 Neighboring gene Sharpr-MPRA regulatory region 9512 Neighboring gene FNDC1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159659176-159659360 Neighboring gene FNDC1 intronic transcript 1 Neighboring gene MPRA-validated peak6281 silencer Neighboring gene uncharacterized LOC105378084 Neighboring gene long intergenic non-protein coding RNA 2529

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis]. Hong H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Aug 20. PMID 36073217, Free PMC Article
  2. Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells. Chen L, et al. Biochem Biophys Res Commun, 2022 Apr 30. PMID 35255438
  3. The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway. Yunwen C, et al. Mol Med Rep, 2021 Jun. PMID 33899120, Free PMC Article
  4. Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown Impairs Cell Invasion and Migration in Gastric Cancer. Liu YP, et al. Technol Cancer Res Treat, 2019 Jan 1. PMID 31530096, Free PMC Article
  5. Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. Gao M, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657397, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer.
    Title: The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer.
  2. [FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis].
    Title: [FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis].
  3. Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells.
    Title: Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells.
  4. The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway.
    Title: The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathway.
  5. The findings elaborated the biological role of fibronectin type III domain containing 1 in gastric cancer and potential mechanism of action, possibly providing a new insight for future clinical diagnosis or even molecular therapy
    Title: Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown Impairs Cell Invasion and Migration in Gastric Cancer.
  6. activator of G-protein signaling 8 regulated the trafficking of VEGFR-3 to the plasma membrane
    Title: VEGFR-3 signaling is regulated by a G-protein activator, activator of G-protein signaling 8, in lymphatic endothelial cells.
  7. these studies have revealed a novel microRNA-1207-3p/FNDC1/FN1/AR regulatory pathway in prostate cancer.
    Title: miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin.
  8. Knockdown of AGS8 inhibited vascular endothelial growth factor (VEGF)-induced tube formation, as well as VEGF-stimulated cell growth and migration.
    Title: Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. mechanical stretching of FN-III1 may induce fibrillogenesis through a partially unfolded intermediate
    Title: Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1866

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibronectin type III domain-containing protein 1
Names
activation-associated cDNA protein
expressed in synovial lining protein
fibronectin type III domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032532.3 → NP_115921.2  fibronectin type III domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_115921.2

    Status: VALIDATED

    Source sequence(s)
    AL356417, AL590551, DQ009660
    Consensus CDS
    CCDS47512.1
    UniProtKB/Swiss-Prot
    A6H8X2, B7ZBR4, B7ZBR5, B9EK49, Q4ZHG4, Q5JPI0, Q5VU31, Q5VU32, Q5VXX4, Q70CQ6, Q96JG1
    UniProtKB/TrEMBL
    J3KNQ2
    Related
    ENSP00000297267.9, ENST00000297267.14
    Conserved Domains (2) summary
    smart00060
    Location:40 → 120
    FN3; Fibronectin type 3 domain
    cd00063
    Location:1658 → 1749
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    159169400..159272108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536190.3 → XP_011534492.1  fibronectin type III domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    J3KNQ2
    Conserved Domains (2) summary
    smart00060
    Location:40 → 120
    FN3; Fibronectin type 3 domain
    cd00063
    Location:1635 → 1726
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_011536191.3 → XP_011534493.1  fibronectin type III domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    J3KNQ2
    Conserved Domains (2) summary
    smart00060
    Location:41 → 124
    FN3; Fibronectin type 3 domain
    cd00063
    Location:1541 → 1632
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    160415015..160517654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356563.1 → XP_054212538.1  fibronectin type III domain-containing protein 1 isoform X1

  2. XM_054356564.1 → XP_054212539.1  fibronectin type III domain-containing protein 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4ZHG4.4 GenPept UniProtKB/Swiss-Prot:Q4ZHG4

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