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ADGRA1 adhesion G protein-coupled receptor A1 [ Homo sapiens (human) ]

Gene ID: 84435, updated on 5-Mar-2024

Summary

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Official Symbol
ADGRA1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor A1provided by HGNC
Primary source
HGNC:HGNC:13838
See related
Ensembl:ENSG00000197177 MIM:612302; AllianceGenome:HGNC:13838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR123
Summary
This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]
Expression
Biased expression in brain (RPKM 3.7), adrenal (RPKM 1.0) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See ADGRA1 in Genome Data Viewer
Location:
10q26.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133087924..133131675)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134037634..134087440)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134901428..134945179)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268067 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:134826346-134827545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134843359-134843972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134844587-134845200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134863995-134864618 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr10:134871141-134872133 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134877264-134877766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134885135-134885816 Neighboring gene MPRA-validated peak1134 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134902582-134903344 Neighboring gene ADGRA1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134911870-134912370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134915449-134916424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134917665-134918227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134918228-134918789 Neighboring gene CEB36 minisatellite repeat instability region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134940316-134941027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134941028-134941740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134953797-134954355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134963792-134964598 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134964599-134965404 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134965405-134966211 Neighboring gene ribosomal protein L5 pseudogene 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134974094-134974683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134974684-134975274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134979051-134979562 Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC105378574

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Essential Role of Adhesion GPCR, GPR123, for Human Pluripotent Stem Cells and Reprogramming towards Pluripotency. Krasnova OA, et al. Cells, 2023 Jan 13. PMID 36672239, Free PMC Article
  2. Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer. Liu Y, et al. Genes Genomics, 2021 Nov. PMID 33945147
  3. Unique transcriptome patterns of the white and grey matter corroborate structural and functional heterogeneity in the human frontal lobe. Mills JD, et al. PLoS One, 2013. PMID 24194939, Free PMC Article
  4. The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells. Lagerström MC, et al. J Neurochem, 2007 Feb. PMID 17212699
  5. Identification of novel splice variants of Adhesion G protein-coupled receptors. Bjarnadóttir TK, et al. Gene, 2007 Jan 31. PMID 17056209

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essential Role of Adhesion GPCR, GPR123, for Human Pluripotent Stem Cells and Reprogramming towards Pluripotency.
    Title: Essential Role of Adhesion GPCR, GPR123, for Human Pluripotent Stem Cells and Reprogramming towards Pluripotency.
  2. Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer.
    Title: Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer.
  3. Studies indicate that the orthologs of GP123 in mouse and rat play a role in the regulation of neuronal signaling pathways.
    Title: The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genes to diseases (G2D) computational method to identify asthma candidate genes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25875, FLJ37356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor A1
Names
G-protein coupled receptor 123
probable G-protein coupled receptor 123

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034069.1 RefSeqGene

    Range
    4921..48672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083909.3 → NP_001077378.1  adhesion G protein-coupled receptor A1 isoform 1

    See identical proteins and their annotated locations for NP_001077378.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL445199, BC044247, DA208698, EF536972
    Consensus CDS
    CCDS41580.1
    UniProtKB/Swiss-Prot
    A5HL16, A6NG50, Q5T234, Q86SN7, Q86SQ6, Q96JJ9
    Related
    ENSP00000376384.3, ENST00000392607.8
    Conserved Domains (1) summary
    cl21561
    Location:26 → 294
    7tm_4; Olfactory receptor

  2. NM_001291085.2 → NP_001278014.1  adhesion G protein-coupled receptor A1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, contains a different 5' structure and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB058731, AL445199, BC044247
    Consensus CDS
    CCDS76362.1
    UniProtKB/Swiss-Prot
    Q86SQ6
    Related
    ENSP00000376383.2, ENST00000392606.2
    Conserved Domains (2) summary
    cd14964
    Location:37 → 53
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 226
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133087924..133131675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016779.2 → XP_016872268.1  adhesion G protein-coupled receptor A1 isoform X2

    Conserved Domains (1) summary
    PHA03247
    Location:117 → 250
    PHA03247; large tegument protein UL36; Provisional

  2. XM_011540273.1 → XP_011538575.1  adhesion G protein-coupled receptor A1 isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:3 → 26
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:1 → 154
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134037634..134087440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366947.1 → XP_054222922.1  adhesion G protein-coupled receptor A1 isoform X2

  2. XM_054366946.1 → XP_054222921.1  adhesion G protein-coupled receptor A1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032422.2: Suppressed sequence

    Description
    NM_032422.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86SQ6.3 GenPept UniProtKB/Swiss-Prot:Q86SQ6

Gene LinkOut

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