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MYH16 myosin heavy chain 16 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 84176, updated on 25-Dec-2023

Summary

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Official Symbol
MYH16provided by HGNC
Official Full Name
myosin heavy chain 16 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:31038
See related
Ensembl:ENSG00000002079 MIM:608580; AllianceGenome:HGNC:31038
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYH5; MHC20; MYH16P
Summary
The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. Stedman et al. (2004) [PubMed 15042088] hypothesized that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7q22.1
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99238829..99311128)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100477712..100550022)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (98836452..98908751)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98631759-98632259 Neighboring gene Sharpr-MPRA regulatory region 1794 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98695995-98696849 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98696850-98697703 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:98700145-98701344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98706490-98706992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18402 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:98749275-98749496 Neighboring gene karyopherin subunit alpha 7 Neighboring gene Sharpr-MPRA regulatory region 10979 Neighboring gene Sharpr-MPRA regulatory region 10425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98848211-98848712 Neighboring gene uncharacterized LOC105375421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18403 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98923087-98923646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:98955605-98956105 Neighboring gene actin related protein 2/3 complex subunit 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98957299-98957799 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:98962524-98962729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98966657-98967570 Neighboring gene Sharpr-MPRA regulatory region 4482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:98970933-98971433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:98991459-98992130 Neighboring gene actin related protein 2/3 complex subunit 1B Neighboring gene PDGFA associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparative analyses reveal a complex history of molecular evolution for human MYH16. Perry GH, et al. Mol Biol Evol, 2005 Mar. PMID 15470226
  2. Myosin gene mutation correlates with anatomical changes in the human lineage. Stedman HH, et al. Nature, 2004 Mar 25. PMID 15042088
  3. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. Desjardins PR, et al. Mol Biol Evol, 2002 Apr. PMID 11919279
  4. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. McGuigan K, et al. Mol Biol Evol, 2004 Jun. PMID 15014174
  5. Comparative genomics search for losses of long-established genes on the human lineage. Zhu J, et al. PLoS Comput Biol, 2007 Dec. PMID 18085818, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration.
    Title: MYH16 upregulation is associated with lung adenocarcinoma aggressiveness and immune infiltration.
  2. first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record
    Title: Myosin gene mutation correlates with anatomical changes in the human lineage.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • myosin heavy polypeptide 5
  • myosin, heavy chain 16
  • myosin, heavy polypeptide 16
  • sarcomeric myosin

Clone Names

  • FLJ22037

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002147.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004834, AC005163, AC112711
    Related
    ENST00000439784.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99238829..99311128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100477712..100550022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6N6.2 GenPept UniProtKB/Swiss-Prot:Q9H6N6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous