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ARHGAP24 Rho GTPase activating protein 24 [ Homo sapiens (human) ]

Gene ID: 83478, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGAP24provided by HGNC
Official Full Name
Rho GTPase activating protein 24provided by HGNC
Primary source
HGNC:HGNC:25361
See related
Ensembl:ENSG00000138639 MIM:610586; AllianceGenome:HGNC:25361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP
Summary
This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in kidney (RPKM 13.8), thyroid (RPKM 4.3) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
4q21.23-q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (85475150..86002666)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (88804774..89332147)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (86396303..86923819)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:86087809-86088309 Neighboring gene RN7SK pseudogene 48 Neighboring gene quinone oxidoreductase-like protein 2 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:86241730-86242929 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:86322472-86323671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21693 Neighboring gene uncharacterized LOC105377319 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:86587778-86588977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21694 Neighboring gene uncharacterized LOC124900728 Neighboring gene Sharpr-MPRA regulatory region 4363 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:86694939-86695479 Neighboring gene NANOG hESC enhancer GRCh37_chr4:86709821-86710322 Neighboring gene microRNA 4451 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:86747140-86747682 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:86996696-86997266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:86997267-86997836 Neighboring gene mitogen-activated protein kinase 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87055698-87056244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87056245-87056789 Neighboring gene MAPK10 antisense RNA 1 Neighboring gene RN7SK pseudogene 96

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM. Saito K, et al. FASEB J, 2021 Apr. PMID 33710706
  2. ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma. Xu G, et al. Oncotarget, 2016 Aug 9. PMID 27385097, Free PMC Article
  3. The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration. Iida T, et al. FEBS Lett, 2016 May. PMID 27130700
  4. Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein. Morishita Y, et al. J Biol Chem, 2015 Oct 23. PMID 26359494, Free PMC Article
  5. FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma. Nishi T, et al. Cancer Med, 2015 Jun. PMID 25641953, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2.
    Title: FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2.
  2. ARHGAP24 represses beta-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.
    Title: ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.
  3. FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
    Title: FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
  4. ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.
    Title: ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.
  5. AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion.
    Title: AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion.
  6. study showed that HOTAIRM1 suppressed ovarian cancer progression through derepression of ARHGAP24 by sponging miR-106a-5p
    Title: HOTAIRM1 suppresses cell proliferation and invasion in ovarian cancer through facilitating ARHGAP24 expression by sponging miR-106a-5p.
  7. Results showed that ARHGAP24 expression was downregulated in lung cancer tissues and cell lines.
    Title: Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating β-Catenin Signaling.
  8. ARHGAP24 can suppress the development of MDA-MB-231 cells via the STAT3 signaling pathway, and sorafenib inhibits cell viability, migration, invasion, and STAT3 activation in MDA-MB-231 cells through ARHGAP24.
    Title: Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
  9. MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24
    Title: MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24.
  10. ARHGAP24 plays a unique role in renal cell carcinoma progression as a tumor repressor.
    Title: ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic determinants of P wave duration and PR segment.
EBI GWAS Catalog
Genome-wide association study of PR interval.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
EBI GWAS Catalog
Several common variants modulate heart rate, PR interval and QRS duration.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33877, DKFZp564B1162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing, spreading of epidermal cells IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 24
Names
RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
filamin-A-associated RhoGAP
rhoGAP of 73 kDa
sarcoma antigen NY-SAR-88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051627.1 RefSeqGene

    Range
    5020..532536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025616.3 → NP_001020787.2  rho GTPase-activating protein 24 isoform 1

    See identical proteins and their annotated locations for NP_001020787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC104059, AK091196, BC098580, DA815489, DB109452
    Consensus CDS
    CCDS34025.1
    UniProtKB/Swiss-Prot
    Q4KMG1, Q6ZNV3, Q86TI5, Q86WE4, Q8N264, Q9H0T6
    UniProtKB/TrEMBL
    A0A2X0SFU2
    Related
    ENSP00000378611.1, ENST00000395184.6
    Conserved Domains (4) summary
    cd04390
    Location:131 → 329
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13379
    Location:18 → 131
    PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain
    pfam00169
    Location:21 → 124
    PH; PH domain
    pfam08614
    Location:609 → 723
    ATG16; Autophagy protein 16 (ATG16)

  2. NM_001042669.2 → NP_001036134.1  rho GTPase-activating protein 24 isoform 3

    See identical proteins and their annotated locations for NP_001036134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC104059, BC098580
    Consensus CDS
    CCDS43246.1
    UniProtKB/TrEMBL
    B3KUX7
    Related
    ENSP00000378610.2, ENST00000395183.6
    Conserved Domains (3) summary
    cd04390
    Location:36 → 234
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl17171
    Location:1 → 36
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:515 → 629
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001287805.2 → NP_001274734.1  rho GTPase-activating protein 24 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC104059, AK307423
    UniProtKB/TrEMBL
    D6RCP5
    Related
    ENSP00000425589.1, ENST00000514229.5
    Conserved Domains (4) summary
    cd04390
    Location:46 → 244
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:14 → 39
    PH; PH domain
    pfam08614
    Location:524 → 638
    ATG16; Autophagy protein 16 (ATG16)
    cl17171
    Location:3 → 46
    PH-like; Pleckstrin homology-like domain

  4. NM_001346093.2 → NP_001333022.1  rho GTPase-activating protein 24 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC097108, AC098870, AC104059, AC139716
    UniProtKB/TrEMBL
    B3KUX7

  5. NM_031305.3 → NP_112595.2  rho GTPase-activating protein 24 isoform 2

    See identical proteins and their annotated locations for NP_112595.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC098870, AC104059, BC098580
    Consensus CDS
    CCDS3611.1
    UniProtKB/TrEMBL
    B3KUX7
    Related
    ENSP00000264343.4, ENST00000264343.4
    Conserved Domains (2) summary
    cd04390
    Location:38 → 236
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam08614
    Location:516 → 630
    ATG16; Autophagy protein 16 (ATG16)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    85475150..86002666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454238.2 → XP_024310006.1  rho GTPase-activating protein 24 isoform X1

    UniProtKB/TrEMBL
    B3KUX7
    Conserved Domains (3) summary
    cd04390
    Location:36 → 234
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl17171
    Location:1 → 36
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:515 → 629
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_047416235.1 → XP_047272191.1  rho GTPase-activating protein 24 isoform X1

  3. XM_011532300.3 → XP_011530602.1  rho GTPase-activating protein 24 isoform X1

    See identical proteins and their annotated locations for XP_011530602.1

    UniProtKB/TrEMBL
    B3KUX7
    Conserved Domains (3) summary
    cd04390
    Location:36 → 234
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl17171
    Location:1 → 36
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:515 → 629
    SMC_N; RecF/RecN/SMC N terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    88804774..89332147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350953.1 → XP_054206928.1  rho GTPase-activating protein 24 isoform X1

  2. XM_054350954.1 → XP_054206929.1  rho GTPase-activating protein 24 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N264.2 GenPept UniProtKB/Swiss-Prot:Q8N264

Gene LinkOut

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