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CAPG capping actin protein, gelsolin like [ Homo sapiens (human) ]

Gene ID: 822, updated on 3-Apr-2024

Summary

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Official Symbol
CAPGprovided by HGNC
Official Full Name
capping actin protein, gelsolin likeprovided by HGNC
Primary source
HGNC:HGNC:1474
See related
Ensembl:ENSG00000042493 MIM:153615; AllianceGenome:HGNC:1474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCP; AFCP; HEL-S-66
Summary
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
2p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85391602..85419540, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85393613..85421559, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85621876..85641139, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 113, pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85628953-85629452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:85640593-85641094 Neighboring gene uncharacterized LOC105374841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16124 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85645284-85645819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16126 Neighboring gene SH2 domain containing 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85658733-85659404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85659405-85660075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85660076-85660746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11700 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85665369-85665885 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85665886-85666401 Neighboring gene RNA, 7SL, cytoplasmic 251, pseudogene Neighboring gene RNA, U7 small nuclear 64 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway. Wang G, et al. Hum Immunol, 2022 Dec. PMID 36244872
  2. Overexpression of CAPG Is Associated with Poor Prognosis and Immunosuppressive Cell Infiltration in Ovarian Cancer. Jiang S, et al. Dis Markers, 2022. PMID 35186171, Free PMC Article
  3. The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG. Prescher N, et al. Free Radic Biol Med, 2021 May 1. PMID 33711419
  4. Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma. Chen ZF, et al. Mol Med Rep, 2021 Jan. PMID 33236143, Free PMC Article
  5. The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? Tinning H, et al. FASEB J, 2020 Aug. PMID 32619075

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway.
    Title: CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway.
  2. CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway.
    Title: CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway.
  3. The Association Between Gelsolin-like Actin-capping Protein (CapG) Overexpression and Bladder Cancer Prognosis.
    Title: The Association Between Gelsolin-like Actin-capping Protein (CapG) Overexpression and Bladder Cancer Prognosis.
  4. The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG.
    Title: The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG.
  5. Oncogenic potential of macrophagecapping protein in clear cell renal cell carcinoma.
    Title: Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma.
  6. The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?
    Title: The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?
  7. CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50.
    Title: CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50.
  8. CAPG competes with the transcriptional repressor arginine methyltransferase 5 (PRMT5) for binding to the STC-1 promoter.
    Title: CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription.
  9. Study suggested that CapG could be used as a biomarker for metastatic CRC in the clinical specimens. Moreover, our in vitro study demonstrated that CapG might contribute on tumor metastasis in human CRCs.
    Title: Capping Actin Protein Overexpression in Human Colorectal Carcinoma and Its Contributed Tumor Migration.
  10. Results revealed that CapG is a novel independent prognostic predictor for glioma patients and highlight a key role of CapG in proliferation and metastasis of glioma.
    Title: Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with CAPG in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of capping protein gelsolin-like (CAPG) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in positive regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of F-actin capping protein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in Flemming body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
macrophage-capping protein
Names
actin-regulatory protein CAP-G
capping protein (actin filament), gelsolin-like
epididymis secretory protein Li 66
gelsolin-like capping protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256139.2 → NP_001243068.1  macrophage-capping protein isoform 1

    See identical proteins and their annotated locations for NP_001243068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AK130130, AK313898, AU099216, BU626913
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Related
    ENSP00000386965.1, ENST00000409724.5
    Conserved Domains (3) summary
    cd11289
    Location:137 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  2. NM_001256140.2 → NP_001243069.1  macrophage-capping protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK130130, AK225374, BU626913
    Consensus CDS
    CCDS58715.1
    UniProtKB/TrEMBL
    B2R9S4
    Related
    ENSP00000387063.1, ENST00000409921.5
    Conserved Domains (3) summary
    cd11289
    Location:137 → 208
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:236 → 331
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  3. NM_001320732.2 → NP_001307661.1  macrophage-capping protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    BG762391, FJ224312
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  4. NM_001320733.2 → NP_001307662.1  macrophage-capping protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    BG762114, FJ224312
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  5. NM_001320734.2 → NP_001307663.1  macrophage-capping protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK130130, BU172582, FJ224312
    UniProtKB/TrEMBL
    B2R9S4
    Conserved Domains (3) summary
    cd11289
    Location:137 → 223
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:221 → 315
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  6. NM_001747.4 → NP_001738.2  macrophage-capping protein isoform 1

    See identical proteins and their annotated locations for NP_001738.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AK130130, BU626913
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Related
    ENSP00000263867.4, ENST00000263867.9
    Conserved Domains (3) summary
    cd11289
    Location:137 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85391602..85419540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445951.1 → XP_047301907.1  macrophage-capping protein isoform X1

  2. XM_047445948.1 → XP_047301904.1  macrophage-capping protein isoform X1

  3. XM_047445950.1 → XP_047301906.1  macrophage-capping protein isoform X1

  4. XM_047445947.1 → XP_047301903.1  macrophage-capping protein isoform X1

  5. XM_047445949.1 → XP_047301905.1  macrophage-capping protein isoform X1

  6. XM_047445952.1 → XP_047301908.1  macrophage-capping protein isoform X1

  7. XM_047445953.1 → XP_047301909.1  macrophage-capping protein isoform X2

    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    V9HW69

  8. XM_011533122.2 → XP_011531424.1  macrophage-capping protein isoform X2

    See identical proteins and their annotated locations for XP_011531424.1

    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  9. XM_011533123.2 → XP_011531425.1  macrophage-capping protein isoform X2

    See identical proteins and their annotated locations for XP_011531425.1

    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  10. XM_047445954.1 → XP_047301910.1  macrophage-capping protein isoform X2

    UniProtKB/Swiss-Prot
    B8ZZS7, D6W5K8, P40121, Q53SA7
    UniProtKB/TrEMBL
    V9HW69

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85393613..85421559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344102.1 → XP_054200077.1  macrophage-capping protein isoform X1

  2. XM_054344101.1 → XP_054200076.1  macrophage-capping protein isoform X1

  3. XM_054344099.1 → XP_054200074.1  macrophage-capping protein isoform X1

  4. XM_054344100.1 → XP_054200075.1  macrophage-capping protein isoform X1

  5. XM_054344104.1 → XP_054200079.1  macrophage-capping protein isoform X2

  6. XM_054344106.1 → XP_054200081.1  macrophage-capping protein isoform X2

  7. XM_054344103.1 → XP_054200078.1  macrophage-capping protein isoform X2

  8. XM_054344105.1 → XP_054200080.1  macrophage-capping protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40121.2 GenPept UniProtKB/Swiss-Prot:P40121

Gene LinkOut

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