U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LAS1L LAS1 like ribosome biogenesis factor [ Homo sapiens (human) ]

Gene ID: 81887, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
LAS1Lprovided by HGNC
Official Full Name
LAS1 like ribosome biogenesis factorprovided by HGNC
Primary source
HGNC:HGNC:25726
See related
Ensembl:ENSG00000001497 MIM:300964; AllianceGenome:HGNC:25726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WTS; Las1; MRXSWTS; Las1-like; dJ475B7.2
Summary
Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 11.3), brain (RPKM 8.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
Xq12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (65512582..65534787, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (63939027..63961232, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64732462..64754667, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene NANOG hESC enhancer GRCh37_chrX:64658617-64659137 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:64683306-64683834 Neighboring gene TLE family member 1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:64713210-64713789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722192-64722692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722693-64723193 Neighboring gene AP1M2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29713 Neighboring gene FERM domain containing 8 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20881 Neighboring gene moesin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29715 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:64924017-64924189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29716 Neighboring gene Sharpr-MPRA regulatory region 13592

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. Castle CD, et al. Mol Cell Biol, 2010 Sep. PMID 20647540, Free PMC Article
  2. Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. Weeks SE, et al. Cell Death Dis, 2021 Mar 4. PMID 33664239, Free PMC Article
  3. Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. Kashiwaya K, et al. Cancer Res, 2010 May 15. PMID 20442285
  4. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Castle CD, et al. Mol Biol Cell, 2012 Feb. PMID 22190735, Free PMC Article
  5. The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression. Bujanic L, et al. RNA, 2022 May. PMID 35232816, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibiting beta-catenin disables nucleolar functions in triple-negative breast cancer.
    Title: Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer.
  2. Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
    Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
  3. LAS1L interacts with PELP1, TEX10, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit.
    Title: LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis.
  4. Analysis of high-molecular-weight RNAs confirmed that Las1L is required for ITS2 processing,which separates the 5.8S and 25S/28S rRNAs, as 32S was found to accumulate and 12S to diminish upon Las1L depletion.
    Title: The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.
  5. Data demonstrate that Las1L is essential for cell proliferation and biogenesis of the 60S ribosomal subunit.
    Title: Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Wilson-Turner syndrome
MedGen: C1839736 OMIM: 309585 GeneReviews: Not available
Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ12525, FLJ30133, FLJ45274

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Las1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosomal biogenesis protein LAS1L
Names
endoribonuclease LAS1L
protein LAS1 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016369.1 RefSeqGene

    Range
    5020..27225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170649.2 → NP_001164120.1  ribosomal biogenesis protein LAS1L isoform 2

    See identical proteins and their annotated locations for NP_001164120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF116730, DA619280
    Consensus CDS
    CCDS55434.1
    UniProtKB/TrEMBL
    A0A7I2V3Q3
    Related
    ENSP00000363940.5, ENST00000374807.9
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  2. NM_001170650.2 → NP_001164121.1  ribosomal biogenesis protein LAS1L isoform 3

    See identical proteins and their annotated locations for NP_001164121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AF116730, DA619280
    Consensus CDS
    CCDS55433.1
    UniProtKB/TrEMBL
    A0A7I2V4E5
    Related
    ENSP00000363937.5, ENST00000374804.9
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 145
    Las1; Las1-like

  3. NM_001375328.1 → NP_001362257.1  ribosomal biogenesis protein LAS1L isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL050306
    UniProtKB/TrEMBL
    A0A7I2V3Q3
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  4. NM_001375329.1 → NP_001362258.1  ribosomal biogenesis protein LAS1L isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL050306
    UniProtKB/TrEMBL
    A0A7I2V5R7
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  5. NM_001375330.1 → NP_001362259.1  ribosomal biogenesis protein LAS1L isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL050306
    UniProtKB/TrEMBL
    A0A7I2V5R7
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  6. NM_001375331.1 → NP_001362260.1  ribosomal biogenesis protein LAS1L isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL050306
    Consensus CDS
    CCDS94620.1
    UniProtKB/TrEMBL
    A0A7I2V3R6, A0A7I2V5R7
    Related
    ENSP00000503577.1, ENST00000676986.1
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  7. NM_001375332.1 → NP_001362261.1  ribosomal biogenesis protein LAS1L isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL050306

  8. NM_001375333.1 → NP_001362262.1  ribosomal biogenesis protein LAS1L isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL050306
    UniProtKB/TrEMBL
    A0A7I2V3Q3
    Related
    ENSP00000503410.1, ENST00000677969.1
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  9. NM_001375334.1 → NP_001362263.1  ribosomal biogenesis protein LAS1L isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL050306
    Consensus CDS
    CCDS94622.1
    UniProtKB/TrEMBL
    A0A7I2V5R7, A0A7I2V653
    Related
    ENSP00000504653.1, ENST00000678956.1
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  10. NM_001375335.1 → NP_001362264.1  ribosomal biogenesis protein LAS1L isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL050306
    Consensus CDS
    CCDS94622.1
    UniProtKB/TrEMBL
    A0A7I2V5R7, A0A7I2V653
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  11. NM_001375336.1 → NP_001362265.1  ribosomal biogenesis protein LAS1L isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL050306
    UniProtKB/TrEMBL
    A0A7I2V5R7
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  12. NM_001375337.1 → NP_001362266.1  ribosomal biogenesis protein LAS1L isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL050306
    UniProtKB/TrEMBL
    A0A7I2V5R7
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  13. NM_001410733.1 → NP_001397662.1  ribosomal biogenesis protein LAS1L isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL050306
    Consensus CDS
    CCDS94621.1
    UniProtKB/TrEMBL
    A0A7I2YQI7
    Related
    ENSP00000503795.1, ENST00000678823.1

  14. NM_031206.7 → NP_112483.1  ribosomal biogenesis protein LAS1L isoform 1

    See identical proteins and their annotated locations for NP_112483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF116730, DA619280
    Consensus CDS
    CCDS14381.1
    UniProtKB/Swiss-Prot
    A9X410, Q5JXQ0, Q8TEN5, Q9H9V5, Q9Y4W2
    UniProtKB/TrEMBL
    A0A7I2V4E5
    Related
    ENSP00000363944.3, ENST00000374811.8
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

RNA

  1. NR_164681.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL050306

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    65512582..65534787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531045.3 → XP_011529347.1  ribosomal biogenesis protein LAS1L isoform X1

    UniProtKB/TrEMBL
    A0A7I2V4E5
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 145
    Las1; Las1-like

  2. XM_047442542.1 → XP_047298498.1  ribosomal biogenesis protein LAS1L isoform X8

  3. XM_047442537.1 → XP_047298493.1  ribosomal biogenesis protein LAS1L isoform X2

  4. XM_047442540.1 → XP_047298496.1  ribosomal biogenesis protein LAS1L isoform X6

  5. XM_047442539.1 → XP_047298495.1  ribosomal biogenesis protein LAS1L isoform X5

  6. XM_047442541.1 → XP_047298497.1  ribosomal biogenesis protein LAS1L isoform X7

    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  7. XM_011531046.3 → XP_011529348.1  ribosomal biogenesis protein LAS1L isoform X3

    UniProtKB/TrEMBL
    A0A7I2V5R7
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

  8. XM_047442538.1 → XP_047298494.1  ribosomal biogenesis protein LAS1L isoform X4

    UniProtKB/TrEMBL
    A0A7I2V653
    Conserved Domains (1) summary
    pfam04031
    Location:43 → 187
    Las1; Las1-like

RNA

  1. XR_007068201.1 RNA Sequence

  2. XR_938412.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    63939027..63961232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327919.1 → XP_054183894.1  ribosomal biogenesis protein LAS1L isoform X1

  2. XM_054327926.1 → XP_054183901.1  ribosomal biogenesis protein LAS1L isoform X8

  3. XM_054327920.1 → XP_054183895.1  ribosomal biogenesis protein LAS1L isoform X2

  4. XM_054327924.1 → XP_054183899.1  ribosomal biogenesis protein LAS1L isoform X6

  5. XM_054327923.1 → XP_054183898.1  ribosomal biogenesis protein LAS1L isoform X5

  6. XM_054327925.1 → XP_054183900.1  ribosomal biogenesis protein LAS1L isoform X7

  7. XM_054327921.1 → XP_054183896.1  ribosomal biogenesis protein LAS1L isoform X3

  8. XM_054327922.1 → XP_054183897.1  ribosomal biogenesis protein LAS1L isoform X4

    UniProtKB/TrEMBL
    A0A7I2V653

RNA

  1. XR_008485509.1 RNA Sequence

  2. XR_008485508.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4W2.2 GenPept UniProtKB/Swiss-Prot:Q9Y4W2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous