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ZNF611 zinc finger protein 611 [ Homo sapiens (human) ]

Gene ID: 81856, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF611provided by HGNC
Official Full Name
zinc finger protein 611provided by HGNC
Primary source
HGNC:HGNC:28766
See related
Ensembl:ENSG00000213020 AllianceGenome:HGNC:28766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 2.4), thyroid (RPKM 2.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52702813..52735044, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55787259..55819509, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53206066..53238297, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 677-like Neighboring gene zinc finger protein 83 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53140536-53141054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53141055-53141572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10996 Neighboring gene Sharpr-MPRA regulatory region 1800 Neighboring gene Zinc finger protein LOC122539214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53167404-53167904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53171845-53172346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:53172853-53174052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53177263-53177762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53179336-53179900 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53179901-53180465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53192883-53193418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53196613-53197148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53199383-53200194 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201006-53201816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201817-53202627 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53219681-53220253 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53259364-53260079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53263091-53263641 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53285228-53285408 Neighboring gene zinc finger protein 600 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53287129-53287305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289004-53289862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289863-53290720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53293023-53293553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53294085-53294614 Neighboring gene zinc finger protein 28 Neighboring gene PABPN1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article
  2. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
  3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 611

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161499.2 → NP_001154971.1  zinc finger protein 611 isoform a

    See identical proteins and their annotated locations for NP_001154971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC022150, BC028590, DA226106, DA245006, DA726181
    Consensus CDS
    CCDS12855.1
    UniProtKB/Swiss-Prot
    B3KRD5, Q69YG9, Q8N823
    Related
    ENSP00000498713.1, ENST00000652185.1
    Conserved Domains (5) summary
    smart00349
    Location:24 → 60
    KRAB; krueppel associated box
    COG5048
    Location:256 → 698
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:540 → 560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:665 → 689
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001161500.2 → NP_001154972.1  zinc finger protein 611 isoform a

    See identical proteins and their annotated locations for NP_001154972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC022150, BC028590, DB122407
    Consensus CDS
    CCDS12855.1
    UniProtKB/Swiss-Prot
    B3KRD5, Q69YG9, Q8N823
    Related
    ENSP00000439211.1, ENST00000540744.5
    Conserved Domains (5) summary
    smart00349
    Location:24 → 60
    KRAB; krueppel associated box
    COG5048
    Location:256 → 698
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:540 → 560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:665 → 689
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001161501.1 → NP_001154973.1  zinc finger protein 611 isoform b

    See identical proteins and their annotated locations for NP_001154973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC022150, BC028590, DA225124
    Consensus CDS
    CCDS54312.1
    UniProtKB/Swiss-Prot
    Q8N823
    Related
    ENSP00000443505.1, ENST00000453741.6
    Conserved Domains (3) summary
    COG5048
    Location:187 → 629
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:471 → 491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:596 → 620
    zf-H2C2_2; Zinc-finger double domain

  4. NM_030972.3 → NP_112234.3  zinc finger protein 611 isoform a

    See identical proteins and their annotated locations for NP_112234.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC022150, AK097434, BC028590, BC143996
    Consensus CDS
    CCDS12855.1
    UniProtKB/Swiss-Prot
    B3KRD5, Q69YG9, Q8N823
    Related
    ENSP00000322427.1, ENST00000319783.5
    Conserved Domains (5) summary
    smart00349
    Location:24 → 60
    KRAB; krueppel associated box
    COG5048
    Location:256 → 698
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:540 → 560
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:665 → 689
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52702813..52735044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55787259..55819509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N823.2 GenPept UniProtKB/Swiss-Prot:Q8N823

Gene LinkOut

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