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INTS5 integrator complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 80789, updated on 7-Apr-2024

Summary

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Official Symbol
INTS5provided by HGNC
Official Full Name
integrator complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:29352
See related
Ensembl:ENSG00000185085 MIM:611349; AllianceGenome:HGNC:29352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT5; KIAA1698
Summary
The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in ovary (RPKM 6.3), thyroid (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62646848..62653302, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62636300..62642755, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62414320..62420774, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384118-62384618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384619-62385119 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62388711-62389304 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62391987-62392312 Neighboring gene glucosidase II alpha subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62412284-62413091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62420185-62420944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4834 Neighboring gene chromosome 11 open reading frame 98 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure of the catalytic core of the Integrator complex. Pfleiderer MM, et al. Mol Cell, 2021 Mar 18. PMID 33548203, Free PMC Article
  2. The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts. Beckedorff F, et al. Cell Rep, 2020 Jul 21. PMID 32697989, Free PMC Article
  3. INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module. Sabath K, et al. Nat Commun, 2020 Jul 9. PMID 32647223, Free PMC Article
  4. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  5. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Vervoort SJ, et al. Cell, 2021 Jun 10. PMID 34004147, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: LBHD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030628.2 → NP_085131.1  integrator complex subunit 5

    See identical proteins and their annotated locations for NP_085131.1

    Status: REVIEWED

    Source sequence(s)
    BC060841
    Consensus CDS
    CCDS8027.1
    UniProtKB/Swiss-Prot
    Q6P9B9, Q8N6W5, Q9C0G5
    Related
    ENSP00000327889.2, ENST00000330574.2
    Conserved Domains (2) summary
    pfam14837
    Location:29 → 251
    INTS5_N; Integrator complex subunit 5 N-terminus
    pfam14838
    Location:290 → 999
    INTS5_C; Integrator complex subunit 5 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62646848..62653302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62636300..62642755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9B9.1 GenPept UniProtKB/Swiss-Prot:Q6P9B9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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