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SLC35F5 solute carrier family 35 member F5 [ Homo sapiens (human) ]

Gene ID: 80255, updated on 3-Apr-2024

Summary

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Official Symbol
SLC35F5provided by HGNC
Official Full Name
solute carrier family 35 member F5provided by HGNC
Primary source
HGNC:HGNC:23617
See related
Ensembl:ENSG00000115084 MIM:619997; AllianceGenome:HGNC:23617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 12.0), adrenal (RPKM 11.9) and 25 other tissues See more
Orthologs
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Genomic context

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See SLC35F5 in Genome Data Viewer
Location:
2q14.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113702682..113756642, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (114127410..114181350, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (114464286..114514219, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2936 Neighboring gene ACR pseudogene 1 Neighboring gene RNA, U6 small nuclear 744, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16425 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:114466525-114467155 Neighboring gene microRNA 4782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16427 Neighboring gene uncharacterized LOC105373570 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:114575557-114576058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:114576059-114576558 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:114588353-114589552 Neighboring gene ACTR3 antisense RNA 1 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
  2. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Rozenblatt-Rosen O, et al. Nature, 2012 Jul 26. PMID 22810586, Free PMC Article
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  4. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22004, FLJ36584

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 35 member F5
Names
HCV NS5A-transactivated protein 3
hepatitis C virus NS5A-transactivated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330314.2 → NP_001317243.1  solute carrier family 35 member F5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3)
    Source sequence(s)
    AC017074
    Consensus CDS
    CCDS82503.1
    UniProtKB/TrEMBL
    B2RDY0, B8ZZY4
    Conserved Domains (2) summary
    COG0697
    Location:239 → 464
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:323 → 464
    EamA; EamA-like transporter family

  2. NM_001330315.2 → NP_001317244.1  solute carrier family 35 member F5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4)
    Source sequence(s)
    AC017074
    UniProtKB/TrEMBL
    B2RDY0
    Conserved Domains (2) summary
    COG0697
    Location:245 → 483
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:342 → 483
    EamA; EamA-like transporter family

  3. NM_001330316.2 → NP_001317245.1  solute carrier family 35 member F5 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5)
    Source sequence(s)
    AC017074
    UniProtKB/TrEMBL
    B2RDY0

  4. NM_001330317.2 → NP_001317246.1  solute carrier family 35 member F5 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, lacks multiple 3' coding exons, and extends past a splice site used in the variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (5) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC017074, AK025657, BC050096
    Consensus CDS
    CCDS86878.1
    UniProtKB/TrEMBL
    B8ZZV6
    Related
    ENSP00000386991.1, ENST00000409342.1

  5. NM_025181.5 → NP_079457.2  solute carrier family 35 member F5 isoform 1

    See identical proteins and their annotated locations for NP_079457.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC017074, AY358620
    Consensus CDS
    CCDS2119.1
    UniProtKB/Swiss-Prot
    Q8WV83, Q9H6P8, Q9H7D8
    UniProtKB/TrEMBL
    B2RDY0
    Related
    ENSP00000245680.2, ENST00000245680.7
    Conserved Domains (1) summary
    COG0697
    Location:242 → 470
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

RNA

  1. NR_104470.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 5' end and lacks a segment in the 3' region. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC017074, BC050096

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    113702682..113756642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445926.1 → XP_047301882.1  solute carrier family 35 member F5 isoform X4

  2. XM_047445923.1 → XP_047301879.1  solute carrier family 35 member F5 isoform X1

    UniProtKB/Swiss-Prot
    Q8WV83, Q9H6P8, Q9H7D8

  3. XM_017005027.2 → XP_016860516.1  solute carrier family 35 member F5 isoform X5

    UniProtKB/TrEMBL
    B2RDY0
    Conserved Domains (2) summary
    COG0697
    Location:245 → 483
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:342 → 483
    EamA; EamA-like transporter family

  4. XM_047445924.1 → XP_047301880.1  solute carrier family 35 member F5 isoform X2

    UniProtKB/TrEMBL
    B8ZZY4
    Related
    ENSP00000386754.1, ENST00000409106.5

  5. XM_047445925.1 → XP_047301881.1  solute carrier family 35 member F5 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    114127410..114181350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344049.1 → XP_054200024.1  solute carrier family 35 member F5 isoform X1

    UniProtKB/Swiss-Prot
    Q8WV83, Q9H6P8, Q9H7D8

  2. XM_054344052.1 → XP_054200027.1  solute carrier family 35 member F5 isoform X5

  3. XM_054344050.1 → XP_054200025.1  solute carrier family 35 member F5 isoform X2

    UniProtKB/TrEMBL
    B8ZZY4

  4. XM_054344051.1 → XP_054200026.1  solute carrier family 35 member F5 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WV83.1 GenPept UniProtKB/Swiss-Prot:Q8WV83

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